Purification and Characterization of an Estradiol-17 beta Binding Macromolecule in Rat Pancreas.

Classical oestrogen receptor is not detectable in pancreatic adenocarcinoma

“…In later reports evidence accumulated for the existence of an oestrogen binding protein in the pancreas of the rat, baboon, dog and man, but the protein appeared to differ from ER (Sandberg et al, 1973;Sandberg & Rosenthal, 1974;Rosenthal & Sandberg, 1978;Pousette et al, 1982;Boctor et al, 1981;Boctor et al, 1983). In contrast, other reports suggested that pancreatic cancer tissue did contain ER.…”

Characterization and Localization of Specific Oestrogen Binding in the Human Thymus

“…I Ani sette ct al. [22] reported a binding protein in the human pancreas, and a circulating plasma protein which was not identical with sex hormone-binding globulin was recently described by O 'Brien et al [23], The higher association constant and the different steroid specificity, however, should rule out the pos sibility that any of those proteins could be identical with the present thymic oestrogenbinding component. Recently, two forms of the oestrogen receptor were recognized in the cytosol fraction of the fetal uterus in the guinea pig [24], Certainly, different forms of the oestrogen receptor might also exist in man.…”

LH – RH Analogue Treatment in Adenocarcinoma of the Pancreas: A Phase II Study

“…The failure of monohormonal treatment with LH-RH analogues may be accounted for by the presence of the mo saic of cell receptors found in either human and experi mentally induced pancreatic adenocarcinoma [4,6,10,[22][23][24], Another reason could be that the sensitivity of single receptors seems to decrease with treatment time, due to a possible down-regulation [17], Also it has been sug gested that complex interactions among receptors take place with a self-regulation by means of phosphorylation [25,26], Obviously all these biological aspects can not be evaluated in clinical trials. Indeed, for an optimal method ological and therapeutic approach, the receptorial pattern of the tumour should be assessed prior to treatment.…”

“…The average survival is 6 months with an overall 5-year survival rate of less than 1% [2], Most of the reports evaluating treatment with cytotoxic drugs and/or radiation did not show any improvement in survival [3], Following the sug gestion by Greenway et al [4], a series of reports [5][6][7][8] have investigated estrogen receptor activity, estradiol binding proteins and growth response to estrogens and anti estrogens in different pancreatic cell lines. In 1983,Iqbalet al [9] found sex-steroid biosynthetic enzymes (aromatase and reductase) in pancreatic cancer tissue, while, in 1986, Corbishley et al [10] demonstrated androgen receptors in pancreatic cells, including human cancer cells.…”