Purification and identification of angiotensin I-converting enzyme inhibitory peptide from buckwheat ( Moench)

Ma, Min-Suk; Bae, In Young; Lee, Hyeon Gyu; Yang, Changyuan

doi:10.1016/j.foodchem.2005.01.052

Cited by 114 publications

(59 citation statements)

References 29 publications

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“…Buckwheat seeds are richer in protein compared with rice and wheat. Buckwheat protein improves health in various ways, notably reducing serum cholesterol (Kayashita et al 1995), suppressing gallstones and tumors (Tomotake et al 2000;Liu et al 2001), and inhibiting the angiotensin I-converting enzyme (Ma et al 2006). Moreover, buckwheat is the only cereal that contains rutin, hence it is a beneficial source of this flavonoid (Holasova et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Changes in phenols contents from buckwheat sprouts during growth stage

Koyama

Nakamura

2011

J Food Sci Technol

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Germinated buckwheat is buckwheat seeds soaked in water just until it begins to bud. Buckwheat sprouts are seedling plants of buckwheat grown up to 10-15 cm. The purpose of this study was to determine the optimal growth period for accumulating the most abundant functional phenol(s) in germinated buckwheat that had been soaked in darkness and buckwheat sprouts cultivated by hydroponic culture. The rutin contained in germinated buckwheat was analyzed by CE (capillary electrophoresis). Phenols, including isoorientin, orientin, isovitexin, vitexin, and rutin were separated from buckwheat sprouts by HPLC and identified by LC-MS. The highest rutin content in germinated buckwheat was found to be 15.8 mg/100 g DW at 20 h after germination. Buckwheat sprouts contained five kinds of major phenols. The highest amounts of isoorientin, orientin, isovitexin, and vitexin were measured at day 3, with the exception of rutin, and then a gradual decrease was observed as the sprouts grew. The quantities of isoorientin, orientin, isovitexin, and vitexin at day 3 were 5.8, 11.7, 26.2, and 28.9 mg/100 g FW, respectively. The rutin content rapidly increased to 109.0 mg/100 g FW until day 6. The highest total phenols in buckwheat sprouts were 162.9 mg/100 g FW at day 6. Germinated buckwheat soaked for 20 h and buckwheat sprouts cultivated for 6 days were rich in dietary phenol(s), which makes these plants a valuable functional food for human consumption.

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Section: Introductionmentioning

confidence: 99%

Changes in phenols contents from buckwheat sprouts during growth stage

Koyama

Nakamura

2011

J Food Sci Technol

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“…ESI-MS data were measured under the following conditions; positive ion mode, 18 C capillary temp., sheath gaschrome: 60,000 mL, 4.5 kV source voltage, 35 V capillary voltage, and 150-1,000 scan range. The 1 H-NMR (500 MHz) and 13 C-NMR (125 MHz) spectra were measured with a Jeol Lambada 500 spectrometer in CDCl 3 , using TMS as an internal standard. Preparative HPLC was performed with a Shimadzu LC-6AD instrument (C30-UG-5 column, 8:0 i.d.…”

Section: Methodsmentioning

confidence: 99%

Functional Compounds in Fermented Buckwheat Sprouts

Maejima

Nakatsugawa

Ichida

et al. 2011

Bioscience, Biotechnology, and Biochemistry

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“…Angiotensin I-converting enzyme (ACE) inhibitory peptide was isolated and identified from buckwheat (Fagopyrum esculentum). The ACE inhibitor was identified to be a tripeptide, Gly-Pro-Pro, having IC 50 value of 6.25 μg protein/ml, by protein sequencing system and electrospray-LC-mass spectrometry [81]. Sixty-seven male and female patients (22-74 years) with chronic venous insufficiency (CVI) were randomly divided into two groups.…”

Section: Cardiovascular and Hypolipidemic Effectsmentioning

confidence: 99%

A review on Fagopyrum esculentum: A potential medicinal plant

Al-Snafi¹

2017

IOSRPHR

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Fagopyrum esculentum contained alkaloids, amino acids, anthraquinones, carbohydrates, flavonoids, phlobatannins and tannins. The nutritional analysis of Fagopyrum esculentum flour and bran revealed that they contained starch: 55, 75 and 18%; proteins: 12, 6 and 36%; lipids: 4, 1 and 11%; soluble carbohydrates: 2, 1 and 6%; total dietary fibers: 7, 3 and 15%; and ash: 2, 1 and 7% respectively. The pharmacological studies showed that Fagopyrum esculentum possessed antioxidant, antiinflammatory, cardiovascular, hypolipidemic, antigenotoxic, antidiabetic, reno-protective, anticancer, antimicrobial, wound healing, antistress, protected memory impairment and photoprotective effects. This review will highligh the chemical constituents and pharmacological effects of Fagopyrum esculentum.

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Purification and identification of angiotensin I-converting enzyme inhibitory peptide from buckwheat ( Moench)

Cited by 114 publications

References 29 publications

Changes in phenols contents from buckwheat sprouts during growth stage

Changes in phenols contents from buckwheat sprouts during growth stage

Functional Compounds in Fermented Buckwheat Sprouts

A review on Fagopyrum esculentum: A potential medicinal plant

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