Purification and identification of novel cytotoxic oligopeptides from soft coral Sarcophyton glaucum

Quah, Yixian; Ismail, Nor Ismaliza Mohd; Ooi, Jillian Lean Sim; Amri, Affendi Yang; Manan, Fazilah Abd; Teh, Lai Kuan; Wong, Fai-Chu; Chai, Tsun-Thai

doi:10.1631/jzus.b1700586

Cited by 16 publications

(10 citation statements)

References 43 publications

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“…These compounds manifested low cytotoxicity on non-cancerous Hek293 cells (Supplementary Table 1). Besides that, AERQ, RDTQ and AGAPGG have cytotoxic activity that is 5.8, 5.1, and 3.3 times stronger than that of the anticancer drug 5-fluorouracil, respectively (Quah et al, 2019).…”

Section: Cnidaria Peptidesmentioning

confidence: 95%

Marine Organisms as a Rich Source of Biologically Active Peptides

et al. 2021

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Oceanic environments are one of the largest sources of bioactive molecules, due to the high degree of biodiversity and the innumerable ecological relationships established between macro and microorganisms found in the different ecosystems of these complex environments. Marine organisms are being studied increasingly because they are considered important producers of biologically active peptides. Peptides extracted from marine sources have different functions and structures, when compared to peptides isolated from terrestrial sources, considering the different adaptive pressures undergone by these organisms throughout the evolutionary process. Most bioactive compounds isolated from marine environments are obtained from symbiont microorganisms. Of these microorganisms, bacteria are an important source of bioactive peptides, isolated by metagenomic studies from complex gene networks expressed under marine conditions. Several peptides have been shown to have biotechnological properties such as antimicrobial, antitumor, antihypertensive, anticoagulant, anti-fouling, and antioxidant activity and can be used in the pharmaceutical and food industries. This review article aims to provide an overview of peptides of biotechnological importance, isolated from different phyla of marine organisms, examining the relationship between structure and function of some of these peptides, as well as the ways of extracting, purifying and prospecting new peptides by traditional methods of isolation or sequence analysis in databases. It also intends to list the peptides that are already being produced and used by the industry, in its various branches, and their current state in the market and in clinical tests.

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Section: Cnidaria Peptidesmentioning

confidence: 95%

Marine Organisms as a Rich Source of Biologically Active Peptides

et al. 2021

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“…Hydrostatin-SN1 was proposed to be a promising candidate for the development of treatments for acute lung injury [ 164 ] and inflammatory bowel diseases [ 371 ]. Bioactive peptides were also reported from the giant barrel sponge, Xestospongia testudinaria [ 373 ] and rough leather coral, Sarcophyton glaucum [ 374 ] KENPVLSLVNGMF derived from X. testudinaria was dose-dependently cytotoxic to the human cervical cancer cell line (HeLa), being 3.8-fold stronger than anticancer drug 5-fluorouracil. By contrast, the peptide showed only a marginal 5% cytotoxicity to Hek293, a non-cancerous, human embryonic kidney cell line [ 374 ].…”

Section: Peptide-based Therapiesmentioning

confidence: 99%

A Global Review on Short Peptides: Frontiers and Perspectives

et al. 2021

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Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with protein-protein interactions, which are indispensable in bio-processes. Short peptides include fundamental molecular information for a prelude to the symphony of life. They have aroused considerable interest due to their unique features and great promise in innovative bio-therapies. This work focusing on the current state-of-the-art short peptide-based therapeutical developments is the first global review written by researchers from all continents, as a celebration of 100 years of peptide therapeutics since the commencement of insulin therapy in the 1920s. Peptide “drugs” initially played only the role of hormone analogs to balance disorders. Nowadays, they achieve numerous biomedical tasks, can cross membranes, or reach intracellular targets. The role of peptides in bio-processes can hardly be mimicked by other chemical substances. The article is divided into independent sections, which are related to either the progress in short peptide-based theranostics or the problems posing challenge to bio-medicine. In particular, the SWOT analysis of short peptides, their relevance in therapies of diverse diseases, improvements in (bio)synthesis platforms, advanced nano-supramolecular technologies, aptamers, altered peptide ligands and in silico methodologies to overcome peptide limitations, modern smart bio-functional materials, vaccines, and drug/gene-targeted delivery systems are discussed.

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“…They displayed relatively high cytotoxicity on HeLa cells (human cervical cancer cells), which was 3.3-, 5.8-, and 5.1-fold stronger than that of the anticancer drug 5-FU, respectively. Additionally, their IC 50 values to inhibit the growth of Hela cells were 8.6, 4.9, and 5.6 mmol/L, respectively [ 41 ].…”

Section: Linear Peptides and Derivativesmentioning

confidence: 99%

Recent Advances in Small Peptides of Marine Origin in Cancer Therapy

et al. 2021

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Cancer is one of the leading causes of death in the world, and antineoplastic drug research continues to be a major field in medicine development. The marine milieu has thousands of biological species that are a valuable source of novel functional proteins and peptides, which have been used in the treatment of many diseases, including cancer. In contrast with proteins and polypeptides, small peptides (with a molecular weight of less than 1000 Da) have overwhelming advantages, such as preferential and fast absorption, which can decrease the burden on human gastrointestinal function. Besides, these peptides are only connected by a few peptide bonds, and their small molecular weight makes it easy to modify and synthesize them. Specifically, small peptides can deliver nutrients and drugs to cells and tissues in the body. These characteristics make them stand out in relation to targeted drug therapy. Nowadays, the anticancer mechanisms of the small marine peptides are still largely not well understood; however, several marine peptides have been applied in preclinical treatment. This paper highlights the anticancer linear and cyclic small peptides in marine resources and presents a review of peptides and the derivatives and their mechanisms.

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Purification and identification of novel cytotoxic oligopeptides from soft coral Sarcophyton glaucum

Cited by 16 publications

References 43 publications

Marine Organisms as a Rich Source of Biologically Active Peptides

Marine Organisms as a Rich Source of Biologically Active Peptides

A Global Review on Short Peptides: Frontiers and Perspectives

Recent Advances in Small Peptides of Marine Origin in Cancer Therapy

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