“…It is unclear what causes the worsening of 2000P. Regardless, we believed that this can be explained by the reduced ability of the hydrophilic peptide segments, comprising of aspartic acid, glutamic acid and/or lysine amino acids [ 43 ], to insert within the more hydrophobic core of the 2000P vesicles comparing to those of the two 1:1 PSMA types. Another possible reason can be drawn by the NMR analysis in Figs.…”