Purification and some properties of phospholipase C from Achromobacter xylosoxidans

Kostadinova, S.; Ivanov, Alexander E.; Kamberov, E.

doi:10.1016/0378-4347(91)80169-d

Cited by 6 publications

(4 citation statements)

References 18 publications

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“…In addition, some members of the genus produce phospholipase C, a key virulence enzyme found in P. aeruginosa, Listeria monocytogenes, and Clostridium perfringens. Phosopholipase C hydrolyzes phospholipids, a key component of alveolar surfactant, which may help to explain these organisms' propensity to cause consolidating pneumonias (47,48).…”

Section: Environmental Advantagementioning

confidence: 99%

Achromobacter Respiratory Infections

Swenson

Sadikot²

2015

Annals ATS

106

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Achromobacteria are ubiquitous environmental organisms that may also become opportunistic pathogens in certain conditions, such as cystic fibrosis, hematologic and solid organ malignancies, renal failure, and certain immune deficiencies. Some members of this genus, such as xylosoxidans, cause primarily nosocomially acquired infections affecting multiple organ systems, including the respiratory tract, urinary tract, and, less commonly, the cardiovascular and central nervous systems. Despite an increasing number of published case reports and literature reviews suggesting a global increase in achromobacterial disease, most clinicians remain uncertain of the organism's significance when clinically isolated. Moreover, effective treatment can be challenging due to the organism's inherent and acquired multidrug resistance patterns. We reviewed all published cases to date of non-cystic fibrosis achromobacterial lung infections to better understand the organism's pathogenic potential and drug susceptibilities. We found that the majority of these cases were community acquired, typically presenting as pneumonias (88%), and were most frequent in individuals with hematologic and solid organ malignancies. Our findings also suggest that achromobacterial lung infections are difficult to treat, but respond well to extended-spectrum penicillins and cephalosporins, such as ticarcillin, piperacillin, and cefoperazone.

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Section: Environmental Advantagementioning

confidence: 99%

Achromobacter Respiratory Infections

Swenson

Sadikot²

2015

Annals ATS

106

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“…Obviously, growth factors of plant origin are needed for optimal enzyme synthesis, as well as carbon sources, which are easy utilized by the microorganism. Casein-soy broth was also found to be the optimal medium for PLC production by Achromobacter xylosoxidans ( 14) and P. jluorescens strain D (13). In minimal tryptose medium production of the enzyme was not detected.…”

Section: Resultsmentioning

confidence: 99%

Phospholipase C fromPseudomonas FluorescensStrain B

Kostadinova¹

1997

Biotechnology & Biotechnological Equipment

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“…Specifically, the Rhodococcus genus was discovered in 1977 and includes mycobacteria-like organisms, of which R. equi is associated with pulmonary masses/infiltrations/abscesses/cavities [ 43 , 44 ]; these pulmonary abscesses extend to the ipsilateral mediastinum and supraclavicular fossa [ 45 ], leading to ipsilateral/unilateral pleural effusions (even with mediastinal (fibrosing pleurisy)) [ 44 , 46 ], bacteremia [ 47 ], bilateral maxillary sinusitis, bilateral necrotic pneumonia, bronchogenic fistula [ 47 ], and acute respiratory distress/shock/death and other diseases [ 48 ]. Inhaling contaminated aerosols seems to be the main form of transmission of Rhodococcus , with most cases involving the lungs [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Fine Particulate Matter Perturbs the Pulmonary Microbiota in Broiler Chickens

Zhou,

Xu,

Wang

et al. 2023

Animals

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(1) Fine particulate matter (PM2.5) seriously affects the respiratory tract health of both animals and humans. Growing evidence indicates that the pulmonary microbiota is involved in the development of respiratory tract health; however, there is still much that is unknown about the specific changes of pulmonary microbiota caused by PM2.5 in broilers. (2) In this experiment, a total of 48 broilers were randomly divided into a control group and PM-exposure group. The experiment lasted for 21 days. Microbiota, inflammation biomarkers, and histological markers in the lungs were determined. (3) On the last day of the experiment, PM significantly disrupted the structure of lung tissue and induced chronic pulmonary inflammation by increasing IL-6, TNFα, and IFNγ expression and decreasing IL-10 expression. PM exposure significantly altered the α and β diversity of pulmonary microbiota. At the phylum level, PM exposure significantly decreased the Firmicutes abundance and increased the abundance of Actinobacteria and Proteobacteria. At the genus level, PM exposure significantly increased the abundance of Rhodococcus, Achromobacter, Pseudomonas, and Ochrobactrum. We also observed positive associations of the above altered genera with lung TNFα and IFNγ expression. (4) The results suggest that PM perturbs the pulmonary microbiota and induces chronic inflammation, and the pulmonary microbiota possibly contributes to the development of lung inflammation.

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Purification and some properties of phospholipase C from Achromobacter xylosoxidans

Cited by 6 publications

References 18 publications

Achromobacter Respiratory Infections

Achromobacter Respiratory Infections

Phospholipase C fromPseudomonas FluorescensStrain B

Fine Particulate Matter Perturbs the Pulmonary Microbiota in Broiler Chickens

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