Purification and Structure of a Novel Cysteine Proteinase Inhibitor, Strepin P-1

Catalytic performance and deactivation of Ni/MCM-41 catalyst in the hydrogenation of pure acetylene to ethylene

“…16,17 Signicant peaks were observed at 3300 and 1540 cm À1 in the infrared spectrum (b) due to the vibration of -NH + , indicating the presence of an aminated functional group. 18,19 Hence, we successfully prepared amino-functionalized MCM-41. We determined the actual Ni loading of the prepared catalyst by ICP in Table 1.…”

Isolation and structure elucidation of two new calpain inhibitors from Streptomyces griseus.

“…Whenboth compounds were co-injected, they also afforded a single peak. A second active compound (2) with an IC50 = 1.2/iM was also isolated from the HP-20 extract using reverse-phase flash and preparative HPLC. HRFAB-MSindicated a molecular formula of C29H40N4O7, consistent with the proposed structure of compound 2.…”

Some Aspects of Guanidine Secondary Metabolites

“…Strepin P-1 (250), isolated from Streptomyces tanabeensis, is a cysteine proteinase inhibitor (444), which also inhibits calpain I, calpain II and papain. The structure of strepin P-1 (250) was determined by spectrometric analysis and enzymatic degradation.…”

“…Finally, natural ( + )-ptilocaulin has been synthesized (656) from (8)-( + )-S-trimethylsilyl-2-cyclohexenone(444) in manner analogous employed to that of SNIDER and FAITH. Finally, natural ( + )-ptilocaulin has been synthesized (656) from (8)-( + )-S-trimethylsilyl-2-cyclohexenone(444) in manner analogous employed to that of SNIDER and FAITH.…”

“…) which involved a rearrangement of a bicyclo[3.2.2]non-6-en-2-one system (422) (653) and a synthesis by HASSNER (654, 655) (Scheme 34) involving an unusual annelation via an intramolecular nitrile oxide-olefin dipolar cycloaddition (INOC) and a rare example of an aldol condensation between a ketone and a protected aldehyde enolate. ·(+)-(444) References, pp. ·(+)-(444) References, pp.…”