Purification, identification, and standardization of silybin A &amp; B composition from <i>Silybum marianum</i> (L.) Gaertn.

Tavakoli, Sina; Khalighi-Sigaroodi, Farahnaz; Hagiaghaee, Reza; Yaghoobi, Mahdi; Ghafarzadegan, R

doi:10.52547/jmp.21.81.1

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…Milk thistle ( Silybum marianum ) seeds have been used for thousands of years as herbal remedies for the treatment of various ailments. The extract from this medicinal plant, known as silymarin, contains several flavonolignans (silybin, isosilibinin, silychristin, isosilychristin, and silydianin) and displays remarkable antioxidant, anti-inflammatory, immunomodulatory, and hepatoprotective properties [ 1 ]. The main component of the silymarin complex is silybin, which comprises a quasiequimolar mixture of two diastereomers: silybin A and silybin B. Silybin has a molecular formula of C 25 H 22 O 10 and its structure is characterized by the amalgamation of a flavonoid unit (taxifolin) and a phenylpropane unit (coniferyl alcohol) [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Thermochemical Transition in Low Molecular Weight Substances: The Example of the Silybin Flavonoid

et al. 2022

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Silybin is a complex organic molecule with high bioactivity, extracted from the plant Silybum. As a pharmaceutical substance, silybin’s bioactivity has drawn considerable attention, while its other properties, e.g., thermodynamic properties and thermal stability, have been less studied. Silybin has been reported to exhibit a melting point, and values for its heat of fusion have been provided. In this work, differential scanning calorimetry, thermogravimetry including derivative thermogravimetry, infrared spectroscopy, and microscopy were used to provide evidence that silybin exhibits a thermochemical transition, i.e., softening occurring simultaneously with decomposition. Data from the available literature in combination with critical discussion of the results in a general framework suggest that thermochemical transition is a broad effect exhibited by various forms of matter (small molecules, macromolecules, natural, synthetic, organic, inorganic). The increased formation of hydrogen bonding contributes to this behavior through a dual influence: (a) inhibition of melting and (b) facilitation of decomposition due to weakening of chemical bonds.

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Section: Introductionmentioning

confidence: 99%

Thermochemical Transition in Low Molecular Weight Substances: The Example of the Silybin Flavonoid

et al. 2022

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“…This plant species is also commonly known by various names such as milk thistle, Mary thistle, Marian thistle, Saint Mary's thistle, Mediterranean milk thistle, variegated thistle, and Scotch milk thistle [2]. Originally native to southern European regions and Asia, this plant has become a cosmopolitan species found in Africa, North and South America, and Australia [3]. In addition to its reddish-purple flowers, this species is characterized by the white patches, or marbling, found along the veins of its dark green leaves [4].…”

Section: Introductionmentioning

confidence: 99%

Analysis of silybin A and silybin B in different accessions of Silybum marianum seeds

Uy,

Shim,

Lee

et al. 2024

JABC

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Silybum marianum more commonly known as milk thistle is one of the most well-researched medicinal plants, particularly for the treatment of liver disease. Silbyin A and silybin B are compounds found in the silymarin complex, the phytochemical responsible for the bioactivity of S. marianum. Silymarin is currently widely used as a dietary supplement. In this study, the contents of the silybin mixture (silybin A and silybin B) in different accessions of S. marianum seeds were determined using high-performance liquid chromatography (HPLC). The aqueous extracts of S. marianum were evaporated and resuspended with HPLC-grade 70% acetonitrile for the analysis. The silybin mixture was quantified using a reverse-phase column with a gradient elution system and a wavelength of 288 nm. Among a total of 14 samples (samples S1-S14) of S. marianum from different accessions, samples S4, S1, and S7 showed particularly high concentrations of silybin A and B, ranging from approximately 19 to 27 mg/g ext. Determining the presence and quantifying the content of the silybin mixture in S. marianum seeds is crucial to identify alternative and optimal sources of therapeutic compounds, thereby increasing the number of available medicines.

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Antiviral and immunostimulatory effects of Ssanti-Covir, a mixed herbal formulation, in cyclophosphamide-treated mice

Pham,

Nguyen-Dung,

Nguyen

et al. 2023

Pharmacological Research - Modern Chinese Medicine

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Purification, identification, and standardization of silybin A & B composition from Silybum marianum (L.) Gaertn.

Cited by 3 publications

References 24 publications

Thermochemical Transition in Low Molecular Weight Substances: The Example of the Silybin Flavonoid

Thermochemical Transition in Low Molecular Weight Substances: The Example of the Silybin Flavonoid

Analysis of silybin A and silybin B in different accessions of Silybum marianum seeds

Antiviral and immunostimulatory effects of Ssanti-Covir, a mixed herbal formulation, in cyclophosphamide-treated mice

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