Purification of active substances of <i>Aloe arborescens</i> miller and their biological and pharmacological activity

Saito, Hiroko

doi:10.1002/ptr.2650070707

Cited by 29 publications

(25 citation statements)

References 15 publications

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“…Aloe vera possesses many health-promoting properties, including anti-inflammatory (Saito 1993;Vazquez et al 1996;Shimpo et al 2002), immunostimulant (Imanishi 1993;Qiu et al 2000), wound healing (Heggers et al 1995;Chitra et al 1998;Rajendran et al 2007), antiulcer (Koo 1994), antidiabetic (Ghannam et al 1986;Ajabnoor 1990;Beppu et al 1993;Okyar et al 2001;Rajesekaran et al 2004) and antitumour (Corsi et al 1998;Pecere et al 2000) in which the mediation of ROS levels could be involved. Werawatganon et al (2014) administered male mice with APAP (400 mg/kg) and Aloe vera (150 mg/kg).…”

Section: Aloe Barbadensis Millermentioning

confidence: 99%

Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity

Eugenio‐Pérez

Oca-Solano

Pedraza‐Chaverrí

2016

Pharmaceutical Biology

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Context Acetaminophen (APAP), also known as paracetamol and N-acetyl p-aminophenol, is one of the most frequently used drugs for analgesic and antipyretic purposes on a worldwide basis. It is safe and effective at recommended doses but has the potential for causing hepatotoxicity and acute liver failure (ALF) with overdose. To solve this problem, different strategies have been developed, including the use of compounds isolated from food, which have been studied to characterize their efficacy as natural dietary antioxidants. Objective The objective of this study is to show the beneficial effects of a variety of natural compounds and their use against acetaminophen-induced hepatotoxicity. Methods PubMed database was reviewed to compile data about natural compounds with hepatoprotective effects against APAP toxicity. Results and conclusion As a result, the health-promoting properties of 13 different food-derived compounds with protective effect against APAP-induced hepatotoxicity were described as well as the mechanisms involved in hepatoprotection.ARTICLE HISTORY

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Section: Aloe Barbadensis Millermentioning

confidence: 99%

Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity

Eugenio‐Pérez

Oca-Solano

Pedraza‐Chaverrí

2016

Pharmaceutical Biology

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“…(synonym A. barbadensis Miller) (Liliaceae) is native in North Africa and is also cultivated in Turkey. Aloe species have been used for centuries for their laxative, antiinflammatory, immunostimulant, antiseptic (Capasso et al, 1998) wound and burn healing (Chithra et al, 1998a(Chithra et al, ,1998bHeggers et al, 1995), antiulcer (Koo, 1994;Saito, 1993) and antitumour (Winters et al, 1981;Saito, 1993) activities. In the past 15 years there have also been reports on the antidiabetic activity of Aloe extracts (Agarwal, 1985;Hikino et al, 1986;Ghannam et al, 1986;Ajabnoor 1990;Beppu et al, 1993Bunyapraphatsara et al, 1995Yangchaiyudha et al, 1996;Bunyapraphatsara et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models

Okyar

Can

Akev

et al. 2001

Phytotherapy Research

162

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Aloe vera (L.) Burm. fil. (= A. barbadensis Miller) (Liliaceae) is native to North Africa and also cultivated in Turkey. Aloes have long been used all over the world for their various medicinal properties. In the past 15 years, there have been controversial reports on the hypoglycaemic activity of Aloe species, probably due to differences in the parts of the plant used or to the model of diabetes chosen. In this study, separate experiments on three main groups of rats, namely, non-diabetic (ND), type I (IDDM) and type II (NIDDM) diabetic rats were carried out. A. vera leaf pulp and gel extracts were ineffective on lowering the blood sugar level of ND rats. A. vera leaf pulp extract showed hypoglycaemic activity on IDDM and NIDDM rats, the effectiveness being enhanced for type II diabetes in comparison with glibenclamide. On the contrary, A. vera leaf gel extract showed hyperglycaemic activity on NIDDM rats. It may therefore be concluded that the pulps of Aloe vera leaves devoid of the gel could be useful in the treatment of non-insulin dependent diabetes mellitus

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“…Lektin-lektin tertentu (suatu tipe protein) yang terkandung dalam gel lidah buaya meningkatkan produksi killer cells, limfosit yang secara alamiah yang membunuh bakteri dan sel-sel tumor (Saito, 1993;Foster, 2005). Syed et al (1997) (Saito, 1993;Foster, 2005).…”

Section: Pendahuluanunclassified

Effect of Aloe vera Gel Administrated on Reproductive Performance of Female Rats

Gunawan¹,

Setiatin

Rosadi

et al. 2007

J Kedokt Hewan

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ABSTRAKPenelitian ini dilaksanakan untuk mengetahui pengaruh pemberian gel Aloe vera secara oral terhadap performansi reproduksi tikus betina. Sebanyak 15 ekor tikus betina berumur 2 bulan mendapat perlakuan pemberian gel Aloe vera secara oral: P0 (kontrol); P1 (1 mg/g BB); P2 (2 mg/g BB); P3 (3 mg/g BB); dan P4 (4 mg/g BB). Gel diberikan setiap hari selama 4 minggu. Berat badan ditimbang pada hari terakhir perlakuan. Kemudian tikus dikawinkan dengan rasio 1 jantan dengan 1 betina. Tikus yang sudah kawin kemudian dieutanasi pada hari ke-10 setelah kopulasi untuk diambil uterus dan ovariumnya untuk menentukan jumlah fetus, CL, serta berat ovarium. Perlakuan berpengaruh terhadap rata-rata berat badan secara signifikan (P<0,05). Perlakuan P0 (4,1 g/ekor/hari) berbeda dengan perlakuan P1 (2,69 g/ekor/hari), P2 (2,87 g/ekor/hari) dan P4 (2,68 g/ekor/hari) namun P0 tidak berbeda dengan P3 (3,39 g/ekor/hari). Tidak ada pengaruh pelakuan terhadap berat ovarium, jumlah corpus luteum (CL), jumlah fetus, dan rasio CL banding fetus.Kata kunci: Aloe vera, tikus, performansi reproduksi ABSTRACTThe research was conducted to find out the effect of Aloe vera gel administrated orally on reproductive performance of female rats. Fifteen two months old female rats were alloted to five treatments of per oral Aloe vera gel administration: P0 (control), P1(1 mg /g body weight), P2 (2 mg/g body weight, P3 (3 mg/g body weight), and P4 ( 4 mg/g body weight). The gel were administrated every day for four weeks. The body weight were measured on the same day as last treatment. The animal then mated to proven male on 1:1 rasio. Positively mated animals were sacrificed on D-10 after mating to collect uterus and ovary so the number of fetus, corpus luteum, and ovary weight can be determined. The treatments significantly decreased (P<0.05) the average body weight gain. The P0 (4.1 g/head/day) was different to P1 (2.69 g/head/day), P2 (2.87 g/head/day, and P4 (2.68 g/head/day), but was not different to P3 (3.39 g/head/day). The ovarium weight were not different (P>0.05) among the treatments, so did the number of corpus luteum (CL), the number of fetuses and the CL: fetus rasio.

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Purification of active substances of Aloe arborescens miller and their biological and pharmacological activity

Cited by 29 publications

References 15 publications

Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity

Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity

Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models

Effect of Aloe vera Gel Administrated on Reproductive Performance of Female Rats

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