Purification of Boron Nitride Nanotubes Enhances Biological Application Properties

Lee, Soul-Hee; Kim, Myung Jong; Ahn, Seokhoon; Koh, Byumseok

doi:10.3390/ijms21041529

Cited by 30 publications

(23 citation statements)

References 41 publications

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“…Boron nitride nanotubes (BNNTs) were originally introduced in 1994 [2], and the arc discharge procedure was used to produce them a year later [3]. Applications in various fields are extremely relevant for sensing applications [4], hydrogen storage [5], capture neutron therapy [6], drug delivery [7], and biomaterial applications [8]. Due to the theory of the adsorption of different molecules such as urea [9], CO 2 [10], NH 3 [11], Ni [12], and anticancer drugs [13] in nanotubes, various experiments have occurred in recent years.…”

Section: Introductionmentioning

confidence: 99%

Boron Nitride Nanotubes for Curcumin Delivery as an Anticancer Drug: A DFT Investigation

et al. 2022

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The electrical properties and characteristics of the armchair boron nitride nanotube (BNNT) that interacts with the curcumin molecule as an anticancer drug were studied using ab initio calculations based on density functional theory (DFT). In this study, a (5,5) armchair BNNT was employed, and two different interactions were investigated, including the interaction of the curcumin molecule with the outer and inner surfaces of the BNNT. The adsorption of curcumin molecules on the investigated BNNT inside the surface is a more favorable process than adsorption on the outside surface, and the more persistent and stronger connection correlates with curcumin molecule adsorption in this case. Furthermore, analysis of the HOMO–LUMO gap after the adsorption process showed that the HOMO value increased marginally while the LUMO value decreased dramatically in the curcumin-BNNT complexes. As a result, the energy gaps between HOMO and LUMO (Eg) are narrowed, emphasizing the stronger intermolecular bonds. As a result, BNNTs can be employed as a drug carrier in biological systems to transport curcumin, an anticancer medication, and thereby improve its bioavailability.

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Section: Introductionmentioning

confidence: 99%

Boron Nitride Nanotubes for Curcumin Delivery as an Anticancer Drug: A DFT Investigation

et al. 2022

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“…Provided boron nitride nanotubes (BNNTs) contain impurities such as amorphous boron, hexagonal boron nitride (h−BN), and amorphous boron nitride (BN) particles [ 29 ]. The purification method of BNNT was referred to in previously published papers [ 30 ]. The detailed purification process is described in the supplementary information .…”

Section: Resultsmentioning

confidence: 99%

Boron Nitride Nanotube-Based Separator for High-Performance Lithium-Sulfur Batteries

et al. 2021

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To prevent global warming, ESS development is in progress along with the development of electric vehicles and renewable energy. However, the state-of-the-art technology, i.e., lithium-ion batteries, has reached its limitation, and thus the need for high-performance batteries with improved energy and power density is increasing. Lithium-sulfur batteries (LSBs) are attracting enormous attention because of their high theoretical energy density. However, there are technical barriers to its commercialization such as the formation of dendrites on the anode and the shuttle effect of the cathode. To resolve these issues, a boron nitride nanotube (BNNT)-based separator is developed. The BNNT is physically purified so that the purified BNNT (p−BNNT) has a homogeneous pore structure because of random stacking and partial charge on the surface due to the difference of electronegativity between B and N. Compared to the conventional polypropylene (PP) separator, the p−BNNT loaded PP separator prevents the dendrite formation on the Li metal anode, facilitates the ion transfer through the separator, and alleviates the shuttle effect at the cathode. With these effects, the p−BNNT loaded PP separators enable the LSB cells to achieve a specific capacity of 1429 mAh/g, and long-term stability over 200 cycles.

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“…However, their applications are limited due to their hydrophobic nature. To obtain a good dispersion of BNNTs in aqueous media and to increase the interfacial bonding of BNNTs with polymer matrix, BNNTs can be functionalized via several approaches [37][38][39][40]. One of them is to coat the surface of BNNTs with hydrophilic polymers [41,42].…”

Section: Introductionmentioning

confidence: 99%

Extrusion-Based Bioprinted Boron Nitride Nanotubes Reinforced Alginate Scaffolds: Mechanical, Printability and Cell Viability Evaluation

Kakarla

Kong

et al. 2022

Polymers

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Alginate (Alg) hydrogels are commonly used as bioinks in 3D bioprinting. However, one of the significant drawbacks of using Alg hydrogels is their unstable mechanical properties. In this study, a novel hydrogel-based ink composed of Alg reinforced with functionalised boron nitride nanotubes (f-BNNTs) was developed and systematic quantitative characterisation was conducted to validate its printability, physiochemical properties and biocompatibility. The printability, contact angle and mechanical test results indicated good structural stability of the scaffolds. The thermal stability of the scaffolds increased with the incorporation of f-BNNTs into Alg. Human embryonic kidney cells (HEK 293T) were seeded on the scaffolds and the cell viability was recorded for 24, 48 and 72 h. Quantitative studies showed a slight effect on toxicity with a higher concentration of BNNTs in scaffolds. The results suggest that the 3D printable f-BNNTs reinforced Alg could be used as bioink for tissue engineering applications with further studies on biocompatibility.

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Purification of Boron Nitride Nanotubes Enhances Biological Application Properties

Cited by 30 publications

References 41 publications

Boron Nitride Nanotubes for Curcumin Delivery as an Anticancer Drug: A DFT Investigation

Boron Nitride Nanotubes for Curcumin Delivery as an Anticancer Drug: A DFT Investigation

Boron Nitride Nanotube-Based Separator for High-Performance Lithium-Sulfur Batteries

Extrusion-Based Bioprinted Boron Nitride Nanotubes Reinforced Alginate Scaffolds: Mechanical, Printability and Cell Viability Evaluation

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