Purified burn toxic factor and its competitin

Rosenthal, Sol Roy; Hawley, Philip L.; Hakim, Amin

doi:10.1097/00006534-197210000-00046

Plastic and Reconstructive Surgery

1972

DOI: 10.1097/00006534-197210000-00046

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Purified burn toxic factor and its competitin

Sol Roy Rosenthal¹,

Philip L. Hawley²,

Amin Hakim³

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1973

1986

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Cited by 3 publications

(3 citation statements)

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“…Several investigators have reported the presence of toxic substances in skin and blood serum of burned experimental animals or of human patients, e.g. Allgower et al, 1973, Rosenthal et al, 1972. In a previous report (Moati et al, 1977) we have described the presence of cardiotoxic and neurotoxic factors in Cohn fractions obtained from the sera of burned patients.…”

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confidence: 83%

Biochemical and pharmacological properties of a neurotoxic protein isolated from the blood serum of heavily burned patients

Sepulchre¹,

Moati²,

Miskulin³

et al. 1979

The Journal of Pathology

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Blood serum of heavily burned patients contains neurotoxic substances which are not present in normal control sera. In the present paper, we describe the purification by gel filtration and ultracentrifugation of such a neurotoxic factor. The purified factor appeared to be a high molecular weight (2 to 3.10(6) daltons) lipoprotein. This factor was present in all the sera of patients with more than 35 per cent of the body surface burned. When injected into rabbits the lipoprotein caused a flattening of the EEG tracing, then trembling and convulsions with bursts of spikes on the EEG. The activity of this neurotoxic substance was enhanced when the permeability of the blood-brain barrier was increased by previous intraventricular injection of collagenase. The presence of such a neurotoxic factor in the blood serum of burned patients, together with the increased serum collagenase activity they exhibit may explain the neurotoxic symptoms observed in them.

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mentioning

confidence: 83%

Biochemical and pharmacological properties of a neurotoxic protein isolated from the blood serum of heavily burned patients

Sepulchre¹,

Moati²,

Miskulin³

et al. 1979

The Journal of Pathology

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“…The substances could be formed in the skin after the burn, transferred into the general circulation and cause damages in other tissues. Several researchers have separated the "toxic substances" of various nature and degree of purity from human or animal skin, or sera, after the burn, and have assessed the toxic activity by various methods [1][2][3][4][5].…”

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confidence: 99%

A Novel Uncoupler of Mitochondrial Respiration, 9, 10-Epoxy-12-octadecenoate, Exists in Human Burned Skin

Yokoo

Hayakawa

Sugiyama

et al. 1986

J. Clin. Biochem. Nutr.

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SummaryIn human burned skin, several polyunsaturated fatty acids, especially linoleate and its peroxide were isolated by high-performance liquid chromatography. Chemical structure of the epoxide was determined to be 9,10-epoxy-12-octadecenoate by gas-chromatography/mass spectrometry, nuclear magnetic resonance measurements and ozonolysis. The epoxide showed an uncoupling activity to liver mitochondria) respiration and diminished the respiratory control of mitochondria. Formation of the epoxide in the burned skin was related to clinical observation of the "burn toxin" which appears after severe burns.

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“…A "toxic glycoprotein" isolated from in vitro scalded human skin depressed the generation of ATFgenerated tension in glycerol-extracted muscle fibers (2)(3)(4).…”

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confidence: 99%

Thermal Injury: Action of Acute Burn Serum on Rat Heart Papillary Muscles

Hakim

Sladek

Rosenthal

1973

Experimental Biology and Medicine

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Purified burn toxic factor and its competitin

Cited by 3 publications

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Biochemical and pharmacological properties of a neurotoxic protein isolated from the blood serum of heavily burned patients

Biochemical and pharmacological properties of a neurotoxic protein isolated from the blood serum of heavily burned patients

A Novel Uncoupler of Mitochondrial Respiration, 9, 10-Epoxy-12-octadecenoate, Exists in Human Burned Skin

Thermal Injury: Action of Acute Burn Serum on Rat Heart Papillary Muscles

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