Purified natural pig immunoglobulins can substitute dietary zinc in reducing piglet post weaning diarrhoea

Hedegaard, Chris Juul; Lauridsen, Charlotte; Heegaard, Peter M. H.

doi:10.1016/j.vetimm.2017.02.001

Cited by 10 publications

(15 citation statements)

References 20 publications

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“…15,23 Chronic inflammation, perceived as a consecutive series of separate inflammatory stimuli, usually shows increased levels of acute-phase proteins, but these levels are usually lower than the levels observed in acute inflammation. 15,24 In addition, the response varies among proteins. 25 In the present study, SAA levels were higher in AU, followed by moderate/severe CU.…”

Section: Discussionmentioning

confidence: 99%

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Serum amyloid A levels in acute and chronic urticaria

Lu¹,

Chen

Wang³

et al. 2019

An. Bras. Dermatol.

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Background: Serum amyloid A is an acute-phase protein. There is no available data regarding serum amyloid A levels in patients with acute (AU) and chronic urticaria (CU). oBjective: To investigate the association between serum amyloid A and urticaria. Methods: This was a case-control study of 81 patients who visited our Hospital between June and December 2016 with a diagnosis of urticaria. Eighty healthy controls (HC) who visited for routine health examination and physical checkups were recruited. Serum amyloid A and C-reactive protein levels were measured by automated methods. results: Serum amyloid A and C-reactive protein levels were significantly higher in AU (Serum amyloid A: 207.1 (6.7-439.0) mg/L; C-reactive protein: 16.0 (0.2-90.0) mg/L) and CU (Serum amyloid A: 6.5 (2.5-35.8) mg/L; C-reactive protein: 1.0 (0.1-16.0) mg/L) compared with HC (Serum amyloid A: 5.04 (2.0-9.1) mg/L; C-reactive protein: 1.2 (0.1-5.6) mg/L), and in AU compared with CU (all P<0.05). There were no differences between the CU and HC group. In CU, Serum amyloid A levels in those with moderate/severe urticaria (median, 16.4 (9.7-35.8) mg/L) were higher than in those with mild urticaria (median, 5.7 (2.5-9.5) mg/L) and HC (all P<0.05). Serum amyloid A and C-reactive protein levels exceeded the normal lab range in 90.7% and 72.1% patients with AU compared with 28.9% and 13.2% patients with CU, respectively. Significant positive correlations were found between serum amyloid A and C-reactive protein (r = 0.562, P < 0.001). study liMitations: There was no comparison between active disease and remission. conclusion: There was an association between serum amyloid A levels and urticaria. Higher serum amyloid A levels were associated with AU and more severe CU. Serum amyloid A may help to identify CU patients earlier.

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Section: Discussionmentioning

confidence: 99%

“…The UAS scores were determined as daily (minimum = 0; and maximum = 6) and over 4 days (sum of the daily score values; minimum = 0; maximum = 24). The UAS was graded as: mild (0-8), moderate (9-16), and severe (17)(18)(19)(20)(21)(22)(23)(24).…”

Section: Urticaria Activitymentioning

confidence: 99%

Serum amyloid A levels in acute and chronic urticaria

Lu¹,

Chen

Wang³

et al. 2019

An. Bras. Dermatol.

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“…No disease data are available from this experiment as no disease was seen after challenge and therefore a follow-up study was done in which disease was obtained upon challenge with the same E. coli type. In this experiment disease was counteracted by ppIgG (oral with feed, 3.8 g/day for 7 days) resulting in less clinical signs of diarrhea and clearance of the challenge strain just as fast as in piglets with access to feed supplemented with dietary zinc oxide for 10 days after weaning (2500 ppm) [ 40 ]. Interestingly, pre-feeding ppIgG for 5 days before challenge and continuing treatment for a total of 15 days did not improve protection compared to treatment for 7 days only, starting 1 day before challenge (at the day of weaning).…”

Section: Immunoglobulinsmentioning

confidence: 99%

“…Interestingly, pre-feeding ppIgG for 5 days before challenge and continuing treatment for a total of 15 days did not improve protection compared to treatment for 7 days only, starting 1 day before challenge (at the day of weaning). Also of interest was that, while numbers of fecal hemolytic bacteria were reduced by both zinc and ppIgG treatment compared to the untreated group, non-hemolytic levels remained unchanged [ 40 ] suggesting a minimal effect of the IgG treatment on the normal microbiota. This would suggest that natural immunoglobulin pools do not contain appreciable activity directed against normal, homeostatic microbiota components, however this will need further investigations to be fully elucidated.…”

Section: Immunoglobulinsmentioning

confidence: 99%

The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production

Dijk

Hedegaard

Haagsman

et al. 2018

Vet Res

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Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and cathelicidins), acute phase proteins and complement activation. As an alternative to antibiotics, innate immune mechanisms are highly relevant as they offer rapid general ways to, at least partially, protect against infections and enable the build-up of a sufficient adaptive immune response. This review describes two classes of promising alternatives to antibiotics based on components of the innate host defense. First we describe immunoglobulins applied to mimic the way in which they work in the newborn as locally acting broadly active defense molecules enforcing innate immunity barriers. Secondly, the potential of host defense peptides with different modes of action, used directly, induced in situ or used as vaccine adjuvants is described.

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“…The pork-producing industry is facing substantial challenges, including abuse of antibiotics, failure of infection control, and nutritional malfunction, particularly at weaning and nursery stages when the gut microbial communities of piglets are immature and vulnerable (Hedegaard et al 2017). Accumulating evidences suggest that the intestinal microbiota in mammals affect a vast range of metabolic activities associated with bacterial growth and exert considerable effects on the health of the host (Conte et al 2006;Shen 2017;Turnbaugh et al 2006).…”

Section: Disccussionmentioning

confidence: 99%

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Supplemental Information 2: The Results of Genus Composition of Each Sample

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Background. The intestinal microbiota plays essential functions that affect piglet health at the weaning stage. However, our understanding of the succession of bacterial intestinal communities during weaning and Nursery Periods of pig is limited. Methods. To better understand this, we performed 16S rDNA gene sequencing of the contents of four distinct intestinal segments [duodenum (D), jejunum (J), ileum (I), and cecum (C)] in six Chinese Shanxi Black pigs at day 25 (B25 group; i.e., weaning) and day 70 (B70 group; i.e., nursery). Results. We found that the dominant phyla are Proteobacteria, Bacteroidetes, and Firmicutes. In addition, the dominant genera were Acinetobacter, Prevotella, Streptococcus, and SMB53 (Clostridiaceae). The microbiota in the B25 group across segments were significantly different from that in the corresponding segments in the B70 group. In addition, the distinct segments in the B70 group presented a continuum consisting of compartmentalized architecture whereas the distinct segments in B25 group were relatively similar. The predicted molecular function analysis revealed higher enrichments in associated metabolisms as well as stress-induced functions in the B25 group. Conclusions. This study provides insights into the succession of intestinal microbiota in Chinese Shanxi Black pigs before and after weaning, and provides reference for improving the intestinal development of piglets.

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Purified natural pig immunoglobulins can substitute dietary zinc in reducing piglet post weaning diarrhoea

Cited by 10 publications

References 20 publications

Serum amyloid A levels in acute and chronic urticaria

Serum amyloid A levels in acute and chronic urticaria

The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production

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