Purinas y ácido úrico en pre-eclampsia: interacciones fisiopatológicas y proyecciones en investigación

Escudero, Carlos; Bertoglia, Patricio; Muñoz, F Iñigo; Roberts, James M.

doi:10.4067/s0034-98872013000700009

Cited by 7 publications

(3 citation statements)

References 43 publications

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“…In fact, these methods have been considered as complementary methods of the current evaluation guidelines for preventing CVD (Kozlov et al, 2012). Also the evaluation of endothelial dysfunction during pregnancy could be a potent tool in the prevention of CVD in early stages of development or in mothers that suffer pregnancy pathologies such as pregnant hypertension, preeclampsia, or GDM (Escudero and Sobrevia, 2008; Escudero et al, 2013). …”

Section: Endothelial Dysfunctionmentioning

confidence: 99%

Physiological mechanisms of vascular response induced by shear stress and effect of exercise in systemic and placental circulation

Rodríguez

González

2014

Front. Pharmacol.

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Physiological vascular function regulation is essential for cardiovascular health and depends on adequate control of molecular mechanisms triggered by endothelial cells in response to mechanical and chemical stimuli induced by blood flow. Endothelial dysfunction is one of the main risk factors of cardiovascular pathology, where the imbalance between the synthesis of vasodilator and vasoconstrictor molecules is common in the development of vascular disorders in systemic and placental circulation. In the placenta, an organ without autonomic innervations, the local control of vascular tone is critical for maintenance of fetal growth and mechanisms that underlie shear stress response induced by blood flow are essential during pregnancy. In this field, shear stress induced by moderate exercise is one of the most important mechanisms to improve vascular function through nitric oxide synthesis and stimulation of mechanical response of endothelial cells triggered by ion channels, caveolae, endothelial NO synthase, and vascular endothelial growth factor, among others. The demand for oxygen and nutrients by tissues and organs, especially in placentation and pregnancy, determines blood flow parameters, and physiological adaptations of vascular beds for covering metabolic requirements. In this regard, moderate exercise versus sedentarism shows potential benefits for improving vascular function associated with the enhancement of molecular mechanisms induced by shear stress. In this review, we collect evidence about molecular bases of physiological response to shear stress in order to highlight the relevance of moderate exercise-training for vascular health in adult and fetal life.

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Section: Endothelial Dysfunctionmentioning

confidence: 99%

Physiological mechanisms of vascular response induced by shear stress and effect of exercise in systemic and placental circulation

Rodríguez

González

2014

Front. Pharmacol.

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“…По мнению С. Escudero и соавт. [25], образованию мочевой кислоты предшествует повышенное количество пуринов в крови матери.…”

Section: новые данные о патогенезе 2-й путьunclassified

Uric acid as an old 'new' marker of preeclampsia and its commplications (a review)

Navolockaya¹,

Lyashko²,

Shifman³

et al. 2018

Probl. reprod.

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академия им. С.И. Георгиевского» Крымского федерального университета им. В.И. Вернадского, Симферополь, Россия В настоящем обзоре рассмотрены современные представления о роли мочевой кислоты в патогенезе преэклампсии, результаты исследования ее показателей при гипертензивных нарушениях, сопровождающих беременность, а также обоснование целесообразности использования мочевой кислоты в качестве маркера преэклампсии и ее осложнений. Изучение динамики показателей мочевой кислоты при гестационной гипертензии позволит выявить потенциальные возможности ранней диагностики преэклампсии и улучшить качество ее лечения.

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“…The origins of high purine levels, increases in purine metabolism as well as the mechanism leading to elevated levels of uric acid in preeclamptic women are unknown. It is possible that trophoblast microparticles released into the circulation as a consequence of placental damage in preeclamptic women may provide the major substrate for purine metabolism and uric acid formation [23,24].…”

Section: Introductionmentioning

confidence: 99%

Elevated circulatingadenosine deaminase activity in women with preeclampsia: association with pro-inflammatory cytokine production and uric acid levels

Giorgi

Bannwart-Castro

Sartori

et al. 2016

Pregnancy Hypertension: An International Journal of Women's Car

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Objective: Preeclampsia is a specific disorder of human pregnancy that is associated with hyperuricemia and higher levels of pro-inflammatory cytokines. Adenosine deaminase (ADA) is an enzyme present in all human tissues, and is considered an indicator of cellular inflammation. In the present study we assess whether adenosine deaminase (ADA) activity is altered in women with preeclampsia (PE) and contributes to elevated levels of uric acid and pro-inflammatory cytokine production. Study design: The population studied consisted of 60 women with PE, 30 normotensive pregnant women (NT) and 20 non-pregnant women (NP). Uric acid concentration and ADA activity were determined in the serum. Peripheral blood mononuclear cells (PBMCs) were isolated and evaluated for intracellular nuclear transcription factor kappa B (NF-jB) levels and for endogenous tumor necrosis factor-a (TNF-a) and interleukin-1b (IL-1b) production. The data were evaluated with parametric or non-parametric tests with significance set at P < 0.05. Results: ADA levels were higher in the PE group compared with the NT and NP groups (P < 0.001). A positive correlation between ADA and uric acid levels was identified in women with PE (P < 0.001). Endogenous production of IL-1b and TNF-a, as well as intracellular NF-jB levels, were higher in PBMCs from the PE group than from NT and NP women (P < 0.01) and correlated with the ADA concentration in preeclamptic women (P < 0.01). Conclusion: An elevation in ADA activity in women with PE may contribute to their increased levels of uric acid and pro-inflammatory immune activity.

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Purinas y ácido úrico en pre-eclampsia: interacciones fisiopatológicas y proyecciones en investigación

Cited by 7 publications

References 43 publications

Physiological mechanisms of vascular response induced by shear stress and effect of exercise in systemic and placental circulation

Physiological mechanisms of vascular response induced by shear stress and effect of exercise in systemic and placental circulation

Uric acid as an old 'new' marker of preeclampsia and its commplications (a review)

Elevated circulatingadenosine deaminase activity in women with preeclampsia: association with pro-inflammatory cytokine production and uric acid levels

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