Purine catabolic enzymes and nitric oxide in patients with recurrent aphthous ulceration

Abstract

Increased XO and AD activities, NO and UA levels and lipid peroxidation were thought to take part in the pathogenesis of RAU. Hence the effects of XO inhibitors in the treatment of RAU should be evaluated in future studies.

Elevated Serum Xanthine Oxidase Activity Is Associated With the Development of Type 2 Diabetes: A Prospective Cohort Study

“…In fact, XO and UA were closely correlated in the metabolic process. UA is the final oxidation product of purine catabolism and catalyzed from xanthine by the XO (31). We examined the relationship between serum XO activity and UA, and there was a significant and positive association.…”

Oxidant/antioxidant status in recurrent aphthous stomatitis

“…However, to date, no principal etiology has been discovered. It has been proposed that the etiological factors lead to aphthae formation via a final common pathway based on increased oxidative stress (Gurel et al , 2007).…”

Comparison of salivary epidermal growth factor in patients with recurrent aphthous stomatitis, smokers, and healthy individuals

“…[3] Recently, free radicals have been suggested to be involved in the etiology of this illness by inducing oxidative stress. [4] When oxygen-free radicals are produced beyond their physiologic limit, or when the antioxidant defense mechanism of the body is reduced, oxidative stress occurs, which can be a life-threatening issue and can lead to histological damage in some cases. [5] Some studies have supported the effect of smoking on the reduced incidence of aphthous lesions but the reason of that is not clear.…”