Purine derivatives with antituberculosis activity

Abstract

The review summarizes the data published over the last 10 – 15 years concerning the key groups of purine derivatives with antituberculosis activity. The structures of purines containing heteroatoms (S, O, N), fragments of heterocycles, amino acids and peptides, in the 6-position, as well as of purine nucleosides are presented. The possible targets for the action of such compounds and structure – activity relationship are discussed. Particular attention is paid to the most active compounds, which are of considerable interest as a basis for the development of efficient antituberculosis drugs. The bibliography includes 99 references.

A Review of the Development of Multitarget Molecules against HIV-TB Coinfection Pathogens

“…Within this scenario of the constant development of resistant strains and the high toxicity of the drugs used in therapy, the search for new therapeutic options becomes imperative. Many groups have been searching for new anti-MTB drugs [21][22][23][24].…”

Metal-free, direct acylation of purines to access C6-acylated purine derivatives induced by TBHP via Minisci-type reaction

“…Purine is one of the most ubiquitous heterocyclic compounds in nature, 1 serving as a major component of adenine and guanine in DNA and RNA. In recent decades, extensive efforts have been made to acquire purines with unique structures due to their broad biological properties, which included anti-virus, 2 anti-coagulant, 3 anti-tuberculosis, 4 anti-cancer, 5 anti-platelet, 6 etc. 7 Among them, the special C 6 -acylated purines have also shown various biological activities, such as anti-mTOR, 8 anti-HIV, 9 anti-HCV 10 and GnRH inhibition, 11 and some of them are shown in Fig.…”

Features of the Сrystal Structure of Benzyl Derivatives of Triacanthine. Effect of Weak Interactions on the Formation of Stable Channel Type Solvates

“…Interest to compounds containing the purine cycle is due by a wide range of their biological activity. Thus, purine derivatives have anticancer [1], antiviral [2], anti-in ammatory [3], antimicrobial and antituberculous [4][5][6] and other activities. Adenine is a nitrogenous base, an amino derivative of purine (6-aminopurine), which is part of many compounds vital for living organisms, such as: adenosine, adenosine phosphatases, adenosine phosphoric acids, nucleic acids, adenine nucleotides etc.…”