2022
DOI: 10.3389/fendo.2022.1049511
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Purinergic signaling in the male reproductive tract

Abstract: Purinergic receptors are ubiquitously expressed throughout the body and they participate in the autocrine and paracrine regulation of cell function during normal physiological and pathophysiological conditions. Extracellular nucleotides activate several types of plasma membrane purinergic receptors that form three distinct families: P1 receptors are activated by adenosine, P2X receptors are activated by ATP, and P2Y receptors are activated by nucleotides including ATP, ADP, UTP, UDP, and UDP-glucose. These spe… Show more

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Cited by 8 publications
(1 citation statement)
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“…Nonetheless, the presence of adenosine receptors in Leydig cells has not been confirmed by other reports and is rather negative [62]. One of the adenosine receptors, the A1 receptor, is present in germ cells and the A3 receptor in Sertoli cells [53,63]. Several paracrine interactions have been suggested between Leydig and Sertoli cells [64,65].…”
Section: Discussionmentioning
confidence: 91%
“…Nonetheless, the presence of adenosine receptors in Leydig cells has not been confirmed by other reports and is rather negative [62]. One of the adenosine receptors, the A1 receptor, is present in germ cells and the A3 receptor in Sertoli cells [53,63]. Several paracrine interactions have been suggested between Leydig and Sertoli cells [64,65].…”
Section: Discussionmentioning
confidence: 91%