Purinergic Signaling Within the Tumor Microenvironment

Lee, Peter P.

doi:10.1007/978-3-030-47189-7_5

Cited by 3 publications

(2 citation statements)

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“…Extracellular release of the central cellular energy metabolite ATP has although evolved as a natural signal for cellular distress, immunogenic cell death (ICD) and the recruitment and activation of immune cells (106). Ectonucleotidases which upregulated in many types of cancer, such as CD39 and CD73, rapidly metabolize eATP to immunosuppressive adenosine, thereafter exacerbating immunosuppression in the TME (107).…”

Section: Adenosine Signaling In Gcmentioning

confidence: 99%

Adenosine signaling: Optimal target for gastric cancer immunotherapy

Wang

Du²,

Chen³

2022

Front. Immunol.

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Gastric cancer (GC) is one of the most common malignancy and leading cause of cancer-related deaths worldwide. Due to asymptomatic or only nonspecific early symptoms, GC patients are usually in the advanced stage at first diagnosis and miss the best opportunity of treatment. Immunotherapies, especially immune checkpoint inhibitors (ICIs), have dramatically changed the landscape of available treatment options for advanced-stage cancer patients. However, with regards to existing ICIs, the clinical benefit of monotherapy for advanced gastric cancer (AGC) is quite limited. Therefore, it is urgent to explore an optimal target for the treatment of GC. In this review, we summarize the expression profiles and prognostic value of 20 common immune checkpoint-related genes in GC from Gene Expression Profiling Interactive Analysis (GEPIA) database, and then find that the adenosinergic pathway plays an indispensable role in the occurrence and development of GC. Moreover, we discuss the pathophysiological function of adenosinergic pathway in cancers. The accumulation of extracellular adenosine inhibits the normal function of immune effector cells and facilitate the effect of immunosuppressive cells to foster GC cells proliferation and migration. Finally, we provide insights into potential clinical application of adenosinergic-targeting therapies for GC patients.

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Section: Adenosine Signaling In Gcmentioning

confidence: 99%

Adenosine signaling: Optimal target for gastric cancer immunotherapy

Wang

Du²,

Chen³

2022

Front. Immunol.

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“…Purines may initiate signal transduction pathways in different cell lineages and tissues. These signaling networks are controlled by specific cell membrane receptors known as purinergic or purinoceptors [ 1 ]. They are classified into two types, metabotropic or P1 receptors and ionotropic or P2 receptors.…”

Section: Introductionmentioning

confidence: 99%

The Tyrosine Phosphatase hPTPRβ Controls the Early Signals and Dopaminergic Cells Viability via the P2X7 Receptor

Llavero

Montoro

Sastre

et al. 2021

IJMS

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ATP, one of the signaling molecules most commonly secreted in the nervous system and capable of stimulating multiple pathways, binds to the ionotropic purinergic receptors, in particular, the P2X7 receptor (P2X7R) and stimulates neuronal cell death. Given this effect of purinergic receptors on the viability of dopaminergic neurons model cells and that Ras GTPases control Erk1/2-regulated mitogen-activated cell proliferation and survival, we have investigated the role of the small GTPases of the Ras superfamily, together with their regulatory and effector molecules as the potential molecular intermediates in the P2X7R-regulated cell death of SN4741 dopaminergic neurons model cells. Here, we demonstrate that the neuronal response to purinergic stimulation involves the Calmodulin/RasGRF1 activation of the small GTPase Ras and Erk1/2. We also demonstrate that tyrosine phosphatase PTPRβ and other tyrosine phosphatases regulate the small GTPase activation pathway and neuronal viability. Our work expands the knowledge on the intracellular responses of dopaminergic cells by identifying new participating molecules and signaling pathways. In this sense, the study of the molecular circuitry of these neurons is key to understanding the functional effects of ATP, as well as considering the importance of these cells in Parkinson’s Disease.

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