Purinergic signalling and immune cells

Burnstock, Geoffrey; Boeynaems, Jean Marie

doi:10.1007/s11302-014-9427-2

Cited by 260 publications

(232 citation statements)

References 577 publications

(483 reference statements)

Supporting

Mentioning

227

Contrasting

Unclassified

Order By: Relevance

“…112 ATP release via pannexin 1 channels in endothelium promotes leukocyte adhesion and emigration. 113 ATP releases ATP from human leukocytes via P2Y 2,4,6, and 11 receptors.…”

Section: Blood Cellsmentioning

confidence: 99%

Purinergic Signaling in the Cardiovascular System

Burnstock

2017

Circulation Research

Self Cite

339

295

View full text Add to dashboard Cite

Abstract:There is nervous control of the heart by ATP as a cotransmitter in sympathetic, parasympathetic, and sensory-motor nerves, as well as in intracardiac neurons. Centers in the brain control heart activities and vagal cardiovascular reflexes involve purines. Adenine nucleotides and nucleosides act on purinoceptors on cardiomyocytes, AV and SA nodes, cardiac fibroblasts, and coronary blood vessels. Vascular tone is controlled by a dual mechanism. ATP, released from perivascular sympathetic nerves, causes vasoconstriction largely via P2X1 receptors. Endothelial cells release ATP in response to changes in blood flow (via shear stress) or hypoxia, to act on P2 receptors on endothelial cells to produce nitric oxide, endothelium-derived hyperpolarizing factor, or prostaglandins to cause vasodilation. ATP is also released from sensory-motor nerves during antidromic reflex activity, to produce relaxation of some blood vessels. Purinergic signaling is involved in the physiology of erythrocytes, platelets, and leukocytes. ATP is released from erythrocytes and platelets, and purinoceptors and ectonucleotidases are expressed by these cells. P1, P2Y 1 , P2Y 12 , and P2X1 receptors are expressed on platelets, which mediate platelet aggregation and shape change. Long-term (trophic) actions of purine and pyrimidine nucleosides and nucleotides promote migration and proliferation of vascular smooth muscle and endothelial cells via P1 and P2Y receptors during angiogenesis, vessel remodeling during restenosis after angioplasty and atherosclerosis. The involvement of purinergic signaling in cardiovascular pathophysiology and its therapeutic potential are discussed, including heart failure, infarction, arrhythmias, syncope, cardiomyopathy, angina, heart transplantation and coronary bypass grafts, coronary artery disease, diabetic cardiomyopathy, hypertension, ischemia, thrombosis, diabetes mellitus, and migraine. (Circ Res. 2017;120:207-228.

show abstract

“…112 ATP release via pannexin 1 channels in endothelium promotes leukocyte adhesion and emigration. 113 ATP releases ATP from human leukocytes via P2Y 2,4,6, and 11 receptors.…”

Section: Blood Cellsmentioning

confidence: 99%

Purinergic Signaling in the Cardiovascular System

Burnstock

2017

Circulation Research

Self Cite

339

295

View full text Add to dashboard Cite

show abstract

“…4 The two ectoenzymes are expressed by a variety of tissue cells and by various cell types of the hematopoietic system. 5 Once released from cells into the extracellular space, ADO engages the P1 ADO receptors, A 1 , A 2A , A 2B and A 3 on target cells. Immune cells express ADOR which contribute to the regulation of immune responses.…”

Section: Introductionmentioning

confidence: 99%

“…Immune cells express ADOR which contribute to the regulation of immune responses. 5 T lymphocytes appear to mainly utilize A 2A R, whereby ADO interacting with the receptor transmits immunosuppressive signals, leading to activation of adenylyl cyclase (AC), upregulation of cAMP levels and inhibition of Teff functions. 6,7 In contrast, peripheral regulatory T cells (pTreg) or myeloid-derived suppressor cells (MDSC) are activated by ADO signaling via A 2A R and their immunosuppressive functions are enhanced.…”

Section: Introductionmentioning

confidence: 99%

Phenotypic and functional characteristics of CD39^highhuman regulatory B cells (Breg)

et al. 2016

View full text Add to dashboard Cite

CD39 and CD73 are key enzymes in the adenosine (ADO) pathway. ADO modulates pathophysiological responses of immune cells, including B cells. It has recently emerged that a subpopulation of ADOproducing CD39 C CD73 C B cells has regulatory properties. Here, we define the CD39 high subset of these cells as the major contributor to the regulatory network operated by human B lymphocytes. Peripheral blood B cells were sorted into CD39 neg , CD39 inter and CD39 high subsets. The phenotype, proliferation and IL-10 secretion by these B cells were studied by flow cytometry. 5 0 -AMP and ADO levels were measured by mass spectrometry. Agonists or antagonists of A 1 R, A 2A R and A 3 R were used to study ADO-

show abstract

“…These extracellular nucleotides trigger multiple downstream events by binding to cell surface receptors called P2 nucleotide receptors, which are divided into two major subfamilies: G-protein-coupled P2Y receptors that can bind ATP, ADP, UTP, UDP and UDP-glucose and ionotropic P2X receptors that are activated by ATP [5]. Most P2X and P2Y receptor subtypes are expressed in immune cells [6]. The stimulation of P2X receptors, in particular P2X7, is a key process in a variety of inflammatory conditions and responses to infectious agents, such as Mycobacterium tuberculosis, Chlamydia trachomatis and Toxoplasma gondii [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

The role of the P2X7 receptor in murine cutaneous leishmaniasis: aspects of inflammation and parasite control

Figliuolo

Chaves

Savio

et al. 2016

Purinergic Signalling

View full text Add to dashboard Cite

Leishmania amazonensis is the etiological agent of diffuse cutaneous leishmaniasis. The immunopathology of leishmaniasis caused by L. amazonensis infection is dependent on the pathogenic role of effector CD4 + T cells. Purinergic signalling has been implicated in resistance to infection by different intracellular parasites. In this study, we evaluated the role of the P2X7 receptor in modulating the immune response and susceptibility to infection by L. amazonensis. We found that P2X7-deficient mice are more susceptible to L. amazonensis infection than wild-type (WT) mice. P2X7 deletion resulted in increased lesion size and parasite load. Our histological analysis showed an increase in cell infiltration in infected footpads of P2X7-deficient mice. Analysis of the cytokine profile in footpad homogenates showed increased levels of IFN-γ and decreased TGF-β production in P2X7-deficient mice, suggesting an exaggerated pro-inflammatory response. In addition, we observed that CD4 + and CD8 + T cells from infected P2X7-deficient mice exhibit a higher proliferative capacity than infected WT mice. These data suggest that P2X7 receptor plays a key role in parasite control by regulating T effector cells and inflammation during L. amazonensis infection.

show abstract

Purinergic signalling and immune cells

Cited by 260 publications

References 577 publications

Purinergic Signaling in the Cardiovascular System

Purinergic Signaling in the Cardiovascular System

Phenotypic and functional characteristics of CD39^highhuman regulatory B cells (Breg)

The role of the P2X7 receptor in murine cutaneous leishmaniasis: aspects of inflammation and parasite control

Contact Info

Product

Resources

About

Purinergic signalling and immune cells

Cited by 260 publications

References 577 publications

Purinergic Signaling in the Cardiovascular System

Purinergic Signaling in the Cardiovascular System

Phenotypic and functional characteristics of CD39highhuman regulatory B cells (Breg)

The role of the P2X7 receptor in murine cutaneous leishmaniasis: aspects of inflammation and parasite control

Contact Info

Product

Resources

About

Phenotypic and functional characteristics of CD39^highhuman regulatory B cells (Breg)