Purines and Hypertension

Su, Che

doi:10.1007/978-1-349-07564-5_15

Purines 1985

DOI: 10.1007/978-1-349-07564-5_15

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Purines and Hypertension

Che Su¹

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1991

1992

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Cited by 2 publications

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Plasma Adenosine Concentrations Are Elevated in Conscious Spontaneously Hypertensive Rats

Yamada

Goto

Ishii

et al. 1992

Clin Exp Pharma Physio

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1. Plasma levels of adenosine were measured in unrestrained, conscious spontaneously hypertensive rats (SHR) to examine the potential role of adenosine, a naturally occurring substance with profound cardiovascular actions, in cardiovascular regulation in these genetically hypertensive rats. 2. We employed a specific and sensitive assay for adenosine based on fluorescent determination of adenine compounds by high performance liquid chromatography. 3. Plasma adenosine concentrations were significantly higher in 13 week old SHR with hypertension than in Wistar-Kyoto rats (0.165 +/- 0.022 vs 0.096 +/- 0.008 mumol/L; P less than 0.05). 4. These observations indicate that plasma adenosine levels are increased in conscious SHR with established hypertension, and also suggest that adenosine may be at least partly involved in the pathophysiology of high blood pressure in SHR.

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Plasma Adenosine Concentrations Are Elevated in Conscious Spontaneously Hypertensive Rats

Yamada

Goto

Ishii

et al. 1992

Clin Exp Pharma Physio

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The effects of adenosine triphosphate (ATP) and related purines on human isolated subcutaneous and omental resistance arteries

Martin

Thorn

Sever

1991

British J Pharmacology

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1Human resistance arteries were obtained from specimens of omentum and subcutaneous fat removed at surgery. They were studied in vitro by use of a myograph technique to determine the effects of purines on the arteries.2 In preparations where tone had been raised with noradrenaline, low concentrations (1 nM-1 gM) of adenosine triphosphate (ATP) and 2-methylthioATP, but not a,,-methyleneATP, produced concentration-dependent relaxation. There was a lack of relationship between the relaxation response to acetylcholine and that to ATP. 3 In preparations under basal tone, high concentrations (1 piM-1 mM) of ATP, 2-methylthioATP and a4,-methyleneATP produced concentration-dependent contractions. 4 The rank order of potency of the purine nucleotide analogues for the relaxation response was 2-methylthioATP > ATP > a4-methyleneATP and for the contractile response it was x,,BmethyleneATP > ATP = 2-methylthioATP. 5 Adenosine produced concentration-dependent relaxation in preparations under raised tone and was less potent than ATP but did not produce contraction in preparations at basal tone. Relaxation responses to adenosine, but not to ATP, were antagonized by 8-phenyltheophylline.6 These results indicate the presence of vasodilator P2Y-and P1-purinoceptors and vasoconstrictor P21-purinoceptors on human resistance arteries isolated from omental and subcutaneous sites.

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Purines and Hypertension

Cited by 2 publications

References 30 publications

Plasma Adenosine Concentrations Are Elevated in Conscious Spontaneously Hypertensive Rats

Plasma Adenosine Concentrations Are Elevated in Conscious Spontaneously Hypertensive Rats

The effects of adenosine triphosphate (ATP) and related purines on human isolated subcutaneous and omental resistance arteries

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