Purinoceptors and Bladder Dysfunction

Abstract

Purinergic signaling is increasingly appreciated as an important contributor to the normal bladder functions of urine storage and voiding. The translation of disease and injury to abnormal sensory and motor function, resulting in lower urinary tract symptoms, is in part mediated by the interaction of adenosine 5′-triphosphate and related purines with specific purinergic receptors (purinoceptors). Identification and clarification of purinoceptor-based processes are important research goals aimed at novel therapeutic targets for functional disorders inadequately served by standard therapies. This review presents an update on recent developments in the understanding of the purinoceptors and bladder dysfunction.

Electroacupuncture Alleviates Bladder Overactivity via Inhabiting Bladder P2X3 Receptor

“…Purinergic signaling is increasingly appreciated as an important contributor to the normal bladder functions of urine storage and voiding. e translation of disease and injury to abnormal sensory and motor function, resulting in lower urinary tract symptoms, is in part mediated by the interaction of adenosine 5′-triphosphate and related purines with specific purinergic receptors [17]. Evidence-Based Complementary and Alternative Medicine e role of purinergic signaling in the regulation of urinary bladder function was established when published reports demonstrated that P2X 2 /P2X 3 knockout animals had significantly altered bladder function.…”