Purkinje tissue modification and ventricular fibrillation

DeSimone, Christopher V.; Asirvatham, Samuel J.

doi:10.1111/pace.13781

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…Specific regions of interest further supported by our study are the papillary muscles and distal trabeculated RV or LV regions. 17–21 Those areas correlate with a high density of Purkinje fibers. Given the small size of the RV in canines, the distance between the base of the right papillary muscles and true apex is much smaller than in humans.…”

Section: Discussionmentioning

confidence: 99%

Regional and Temporal Variation of Ventricular and Conduction Tissue Activity During Ventricular Fibrillation in Canines

Tan

Christopoulos

Ladas

et al. 2021

Circ: Arrhythmia and Electrophysiology

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Background: Rigorous study of ventricular fibrillation (VF) is not feasible in humans. The spatiotemporal characteristics of prolonged VF remain undefined, limiting our understanding of this lethal rhythm. Methods: VF was mapped in 4 canines. The endocardial and epicardial left ventricle (LV) and right ventricle (RV) were sequentially mapped at 0 to 15, 15 to 30, 30 to 45, and 45 to 60 minutes post-induction. Ten consecutive beats were used to determine average cycle length and regularity index of ventricular and His-Purkinje system signals in discrete regions during each time interval. Results: Average VF time was 58±12 minutes. The shortest ventricular cycle length was present in the RV apical region (70±10 msec) at 0 to 15 minutes and at 15 to 30 minutes (89±31 msec) and LV apical region at 45 to 60 minutes (242±163 msec). The His-Purkinje system cycle length was the shortest at the RV outflow tract (75±3 msec) at 0 to 15 minutes, RV inflow and free wall (89±12 msec) at 15 to 30 minutes, LV apical region (83±14 msec) at 30 to 45 minutes, and inferior and inferolateral LV (145±23 msec) at 45 to 60 minutes. Regularity index was the highest in the RV inflow and free wall (78%) at 0 to 15 minutes, RV apical region (86%) at 15 to 30 minutes, LV septum and epicardial anterior RV (80%) at 30 to 45 minutes, and anterior and anterolateral LV (75%) at 45 to 60 minutes. Conclusions: These data suggest significant regional changes in electrical activity throughout VF in canines. A transition of fastest electrical activity from RV to LV apical regions across VF was observed. Further studies are warranted to confirm the above findings.

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Section: Discussionmentioning

confidence: 99%