Purmorphamine Alters Anxiety-Like Behavior and Expression of Hedgehog Cascade Components in Rat Brain after Alcohol Withdrawal

Peregud, Danil I.; Shirobokova, Nataliya I.; Kvichansky, Aleksei A.; Stepanichev, Mikhail Yu.; Gulyaeva, Natalia V.

doi:10.1134/s0006297924110087

Biochemistry Moscow

2024

DOI: 10.1134/s0006297924110087

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Purmorphamine Alters Anxiety-Like Behavior and Expression of Hedgehog Cascade Components in Rat Brain after Alcohol Withdrawal

Danil I. Peregud,

Nataliya I. Shirobokova,

Aleksei A. Kvichansky

et al.

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2024

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An Intricated pas de deux of Addicted Brain and Body Is Orchestrated by Stress and Neuroplasticity

Gulyaeva,

Peregud

2024

Biochemistry Moscow

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Dependence on psychoactive substances is a phenomenon that is based on the alterations of common molecular and cellular mechanisms, structures and neuronal networks underlying normal brain functioning and realizing stress response, reinforcement and aversion, learning and memory. As a result, aberrant neuroplasticity states associated with somatic changes are formed, which determine the pathogenesis and symptoms of dependence and at the same time can be considered as targets for the development of therapies for such addictions. An integrative scheme of stress and neuroplastic changes participation in the formation of the vicious circle of substance use disorders based on a holistic approach is presented. This special issue of the journal focuses on the molecular mechanisms of psychoactive substance use disorders.

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An Intricated pas de deux of Addicted Brain and Body Is Orchestrated by Stress and Neuroplasticity

Gulyaeva,

Peregud

2024

Biochemistry Moscow

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Purmorphamine Alters Anxiety-Like Behavior and Expression of Hedgehog Cascade Components in Rat Brain after Alcohol Withdrawal

Cited by 1 publication

References 50 publications

An Intricated pas de deux of Addicted Brain and Body Is Orchestrated by Stress and Neuroplasticity

An Intricated pas de deux of Addicted Brain and Body Is Orchestrated by Stress and Neuroplasticity

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