Purple–brown coalescing macules on the mandibular area of the face

Abstract

A 71-year-old white man with Fitzpatrick skin phototype III presented with a 1-year history of asymptomatic pigmented macules on his face. His medical history was unremarkable. Physical examination revealed violaceous-brown coalescing reticulated macules, which were more prominent on both mandibular regions and very faint over the cheeks, with slight lamellar peeling and without infiltration (Fig. 1a). There were no changes in other skin areas, or in the hair, nails or oral mucosa. Routine laboratory tests were within normal ranges, and antinuclear antibody (ANA) test was negative. Histopathological findingsHistological examination of a punch biopsy specimen showed a thin epidermis, interface dermatitis, basal vacuolar degeneration, a moderately dense, perivascular and mildly interstitial lymphocytic infiltrate, moderate pigmentary incontinence, colloid body formation and prominent solar elastosis (Fig. 1b).

Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel: Two Case Reports

“…Selective inflammation of AK during chemotherapy is possibly a consequence of direct cytotoxicity of an active compound on atypical keratinocytes that accumulate ultraviolet-induced damage of deoxyribonucleic acid, but the exact mechanism of how different chemotherapeutics achieve this effect seems to be drug-dependent [ 13 ]. Alternative explanations of skin lesions (i.e., subacute lupus erythematosus, actinic lichen planus, cutaneous vasculitis, hypersensitivity drug reactions, drug-induced photosensitivity reactions, and photocontact dermatitis) were in both patients excluded on the basis of a history, typical clinical features of AK, and in the first case with the additional characteristic presence of atypical keratinocytes on histological examination [ 14 , 15 , 16 , 17 , 18 , 19 , 20 ].…”