Purple corn color suppresses Ras protein level and inhibits 7,12‐dimethylbenz[<i>a</i>]anthracene‐induced mammary carcinogenesis in the rat

Fukamachi, Katsumi; Imada, Takafumi; Ohshima, Yutaka; Xu, Jiegou; Tsuda, Hiroyuki

doi:10.1111/j.1349-7006.2008.00895.x

Cited by 31 publications

(19 citation statements)

References 51 publications

(70 reference statements)

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“…is a subtropical native Chinese fruit with high nutrient and health values. The red-colored Chinese bayberry pulp is a rich source of anthocyanins, especially cyanidin-3-glucoside (C3G) [14], which has been well characterized as having anticancer activity in vitro [15] and in vivo [16]. Previous studies have demonstrated that the in vitro anticancer activities of anthocyanins are exerted through mechanisms of promotion of apoptosis [17], inhibition of cell cycle [18] and cell invasion [5,19].…”

Section: Introductionmentioning

confidence: 99%

The Growth of SGC-7901 Tumor Xenografts Was Suppressed by Chinese Bayberry Anthocyanin Extract through Upregulating KLF6 Gene Expression

et al. 2016

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To investigate the antitumor effect of anthocyanins extracted from Chinese bayberry fruit (Myrica rubra Sieb. et Zucc.), a nude mouse tumor xenograft model was established. Treatments with C3G (cyanidin-3-glucoside, an anthocyanin) significantly suppressed the growth of SGC-7901 tumor xenografts in a dose-dependent manner. Immunohistochemical staining showed a significant increase in p21 expression, indicating that the cell cycle of tumor xenografts was inhibited. qPCR screening showed that C3G treatment up-regulated the expression of the KLF6 gene, which is an important tumor suppressor gene inactivated in many human cancers. Western blot showed that C3G treatments markedly increased KLF6 and p21 protein levels, inhibited CDK4 and Cyclin D1 expression, but did not notably change the expression of p53. These results indicated that KLF6 up-regulates p21 in a p53-independent manner and significantly reduces tumor proliferation. This study provides important information for the possible mechanism of C3G-induced antitumor activity against gastric adenocarcinoma in vivo.

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Section: Introductionmentioning

confidence: 99%

The Growth of SGC-7901 Tumor Xenografts Was Suppressed by Chinese Bayberry Anthocyanin Extract through Upregulating KLF6 Gene Expression

et al. 2016

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“…Purple corn is a special cultivar of corn that is rich in anthocyanins and other functional phytochemicals, and has been regarded as a health-promoting food that is widely consumed in Peru and other Andean countries (Aoki, Kuze, & Kato, 2002;Jones, 2005). The health benefits of anthocyanins in purple corn have been attributed to their high antioxidant activities and to other mechanisms, such as the presence of components that have been shown to potentially reduce the risk of colon cancer by inhibiting the proliferation of human colon cancer cells in vitro (Fukamachi, Imada, Ohshima, Xu, & Tsuda, 2001;Hagiwara et al, 2001). These compounds have also been shown to help prevent heart ischaemia-reperfusion injury, cerebrovascular diseases (Toufektsian et al, 2008), diabetes and obesity (Tsuda, Horio, Uchida, Aoki, & Osawa, 2003).…”

Section: Introductionmentioning

confidence: 99%

Anthocyanins and antioxidant activity in coloured waxy corn at different maturation stages

Harakotr

Suriharn

Tangwongchai

et al. 2014

Journal of Functional Foods

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“…Otras antocianinas identificadas fueron cianidina 3-(6"-malonil glucósido) y peonidina 3-glucósido (Yolanda et al, 2013). La cianidina 3-glucósido, una importante antocianina presente en el maíz morado, suprime el 7,12-dimethilbenzo antraceno, el cual induce a la carcinogénesis mamaria, lo que indica que el color de maíz morado puede ser un agente quimioterapéutico prometedor (Fukamachi et al, 2008).…”

Section: Componentes Benéficos Del Maíz Moradounclassified

Características y propiedades funcionales del maíz morado (Zea mays L.) var. subnigroviolaceo

2010

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ResumenEl maíz morado es una planta oriunda de América, que tiene el epispermo de las semillas (granos) y la tusa (coronta) de color morado, lo que le otorga características especiales a los pigmentos que poseen (entre 1,5% y 6,0%), llamados antocianinas, que pertenecen al grupo de los flavonoides. Debido a su alto contenido de antocianinas (cianin-3-glucosa C3G que es su principal colorante) y compuestos fenólicos actúa como un poderoso antioxidante natural y anticancerígeno, teniendo además propiedades funcionales debido a estos compuestos bioactivos. El maíz morado además aporta cantidades importantes de almidón, cerca del 80%; un 10% de azúcares los cuales le confieren un sabor dulce, un 11% de proteínas, 2% de minerales y vitaminas (complejo B y ácido ascórbico) concentrados en el endospermo. Además del valor nutricional, el maíz morado tiene una composición rica en fitoquímicos, que tienen efectos benéficos en nuestro cuerpo, tales como neutralizar los radicales libres y actuar como antimutagénico. Este trabajo de revisión tuvo como objetivo, recopilar información sobre los estudios realizados al maíz morado, como alternativa al uso de colorantes artificiales de alimentos y por sus beneficios a la salud al incluirlo en la dieta, tales como, enfermedades cardiovasculares (hipertensión arterial), reducción del colesterol, lucha contra la diabetes, siendo el más resaltante la acción antioxidante (antiarrugas).Palabras clave: Antocianina, Flavonoide, Fitoquímico, Propiedades funcionales, Compuestos Bioactivos. AbstractZea Mays L. variety purple (purple corn) is a plant native of America, which has the episperm seeds (grains) and the cobs (cob) in purple, which gives special characteristics to the pigments that have (between 1.5% and 6.0%), called anthocyanins, which belong to the group of flavonoids. Due to its high content of anthocyanins (cianin C3G-3-glucose as its main color) and phenolic compounds act as powerful natural antioxidant and anticancer, Further having functional properties due to these bioactive compounds. The purple corn also provides significant amounts of starch, about 80% (complex carbohydrate), 10% of sugars provide sweetness, up to 11% protein, up to 2% minerals and B vitamins and ascorbic acid, concentrated in endosperm (grain free envelope). Also the nutritional value, the purple corn has a rich composition of phytochemicals, which have beneficial effects on our body, such as neutralize free radicals and act as antimutagenic. His review paper aimed to collect information on the studies undertaken to purple corn as an alternative to artificial food dyes and health benefits when included in the diet. Benefits such as cardiovascular diseases (hypertension), lowering cholesterol, fighting diabetes, being the most remarkable antioxidant action (wrinkle).

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Purple corn color suppresses Ras protein level and inhibits 7,12‐dimethylbenz[a]anthracene‐induced mammary carcinogenesis in the rat

Cited by 31 publications

References 51 publications

The Growth of SGC-7901 Tumor Xenografts Was Suppressed by Chinese Bayberry Anthocyanin Extract through Upregulating KLF6 Gene Expression

The Growth of SGC-7901 Tumor Xenografts Was Suppressed by Chinese Bayberry Anthocyanin Extract through Upregulating KLF6 Gene Expression

Anthocyanins and antioxidant activity in coloured waxy corn at different maturation stages

Características y propiedades funcionales del maíz morado (Zea mays L.) var. subnigroviolaceo

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