2021
DOI: 10.1080/19768354.2021.1974938
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Purple corn extract alleviates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like phenotypes in BALB/c mice

Abstract: Zea mays L. (Poaceae), also known as purple corn, is an annual herbaceous plant that is grown as food for human consumption in a variety of forms, including cooking oils and sweeteners in processed food and beverage products. The purpose of this study was to determine whether a novel purple corn extract, FB801, might have an anti-atopic dermatitis (AD) effect on AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) in BALB/c mice. Topical sensitization (1%) and challenge (0.3%) by DNCB were performed… Show more

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Cited by 7 publications
(2 citation statements)
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“…The Th2 cytokines IL-5 and IL-4 take an role in AD by increasing IgE production and eosinophils [ 3 ]. The alleviating effect of red corn extract on AD in DNCB-induced mice [ 5 ] and the anti-atopic activity of ethanol extract from tuna heart [ 6 ] that produce decreased IFN-γ and enhanced proportion of allergen-specific T cells associated with increased IL-5 and IL-4 have been reported in peripheral blood smears of AD patients. The cause of atopy is not yet known, but genetic, immunological , and environmental factors are known to predispose patients to this disorder [ 7 ].…”
Section: Introductionmentioning
confidence: 99%
“…The Th2 cytokines IL-5 and IL-4 take an role in AD by increasing IgE production and eosinophils [ 3 ]. The alleviating effect of red corn extract on AD in DNCB-induced mice [ 5 ] and the anti-atopic activity of ethanol extract from tuna heart [ 6 ] that produce decreased IFN-γ and enhanced proportion of allergen-specific T cells associated with increased IL-5 and IL-4 have been reported in peripheral blood smears of AD patients. The cause of atopy is not yet known, but genetic, immunological , and environmental factors are known to predispose patients to this disorder [ 7 ].…”
Section: Introductionmentioning
confidence: 99%
“…As normal histopathological tests often involve general staining such as hematoxylin–eosin (H&E) staining (No et al 2021 ; Roh et al 2021 ), the development of a fluorescence staining equivalent to H&E staining is important. Eosin labels cytosol in red and exhibits red fluorescence via the conventional rhodamine filter setup of a fluorescence microscope.…”
Section: Introductionmentioning
confidence: 99%