Purple eyelid sign in multisystem inflammatory syndrome in children

Komatsu, Yosuke; Nozawa, Tomo; Kamiyama, Yuji; Hattori, Seira; Nishimura, Kenichi; Ito, Shuichi

doi:10.1111/ped.15510

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…In addition to infectious diseases, eyelid edema can also be observed in Kawasaki disease. Moreover, Komatsu et al reported the presence of the purple eyelid sign in children with multisystem inflammatory syndrome (MIS-C) [3]. In the present case, our patient was not diagnosed with MIS-C or Kawasaki disease since she did not report any gastrointestinal symptoms and thus did not meet the diagnostic criteria for complete or incomplete Kawasaki disease [4].…”

Section: Discussionmentioning

confidence: 73%

Bilateral Eyelid Edema in a Pediatric Patient With COVID-19: A Case Report and Literature Review

Shimazaki¹,

Sato²,

Niwa³

2023

Cureus

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is primarily transmitted through the eyes, nose, or mouth. Ophthalmic complications, such as conjunctivitis and dacryoadenitis, have been reported in patients with coronavirus disease 19 . We report the case of an early adolescent girl who presented with bilateral urticarial rashes, eyelid edema, fever, and cough. She was diagnosed with acute dacryoadenitis with SARS-CoV-2 infection confirmed by a nasopharyngeal polymerase chain reaction and clinical investigations. The patient was treated with dexamethasone (3 mg daily) for three days, which resulted in the resolution of fever and urticarial rash, and improvement of eyelid edema. While bilateral upper eyelid edema and acute dacryoadenitis commonly occur in pediatric patients due to Epstein-Barr virus (EBV) infection and Kawasaki disease, they are rarely associated with other diseases. However, ocular symptoms have been reported in 11.4% of patients with COVID-19. In addition, eyelid edema and acute dacryoadenitis have also been reported after COVID-19 messenger RNA (mRNA) vaccination. The underlying mechanisms of these complications are not yet completely understood. Our case highlights the possibility of bilateral eyelid edema in children with COVID-19, which can occur in addition to other viral infections such as EBV.

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Section: Discussionmentioning

confidence: 73%

Bilateral Eyelid Edema in a Pediatric Patient With COVID-19: A Case Report and Literature Review

Shimazaki¹,

Sato²,

Niwa³

2023

Cureus

View full text Add to dashboard Cite

show abstract

“…Young et al reported periorbital erythema and edema in 20% of studied MIS‐C patients, a manifestation that has previously been reported to be an important sign of the disease 2 . Recently, Komatsu et al emphasized that purple eyelid edema is a specific sign of MIS‐C 10 . However, in 2006 Chakrabartty et al reported “hyperemia in the upper eyelids” as an important clinical finding in 32% of difficult‐to‐diagnose KD cases 11 .…”

Section: Kawasaki Disease Mis‐cmentioning

confidence: 96%

Notes on cutaneous manifestations of Kawasaki disease and multisystem inflammatory syndrome in children

2023

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Purple eyelid sign in multisystem inflammatory syndrome in children

Abstract: Example of the purple eyelid sign in multisystem inflammatory syndrome in children. (a) and (b), Case 3; (c), Case 4; (d), Case 5; (e), Case 6. We obtained the consent of the patients' families to use their photographs.

Cited by 2 publications

References 4 publications

Bilateral Eyelid Edema in a Pediatric Patient With COVID-19: A Case Report and Literature Review

Bilateral Eyelid Edema in a Pediatric Patient With COVID-19: A Case Report and Literature Review

Notes on cutaneous manifestations of Kawasaki disease and multisystem inflammatory syndrome in children

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