Purple red rice anthocyanins alleviate intestinal damage in cyclophosphamide-induced mice associated with modulation of intestinal barrier function and gut microbiota

Chen, Ting; Shen, Mingyue; Yu, Qiang; Chen, Yi; Wen, Huiliang; Lu, Hanyu; Chen, Shuai; Xie, Jianhua

doi:10.1016/j.foodchem.2022.133768

Cited by 39 publications

(29 citation statements)

References 37 publications

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“…This systematic review and meta-analysis demonstrated that dietary anthocyanin supplementation profoundly improves rodent models' gut health biomarkers (Fir/Bac and SCFAs). This finding was supported by studies carried out after cut off time limit of this studies 77 – 81 .…”

Section: Discussionsupporting

confidence: 85%

Effect of anthocyanins on gut health markers, Firmicutes-Bacteroidetes ratio and short-chain fatty acids: a systematic review via meta-analysis

Kapoor

Tiwari

Sharma

et al. 2023

Sci Rep

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Researchers discovered that diets rich in anthocyanin-rich fruits and vegetables significantly impacted gut flora. To conclude, large-scale randomized controlled clinical trials are challenging to conduct; therefore, merging data from multiple small studies may aid. A systematic review collects and analyses all research on a particular subject and design. This comprehensive review and meta-analysis examined the influence of dietary anthocyanins on Firmicutes/Bacteroide (Fir/Bac) and short-chain fatty acids (SCFAs) content. The current meta-analysis followed the guidelines of PRISMA—the preferred reporting items for systematic reviews and meta-analyses. Diets high in anthocyanins substantially reduced the Fir/Bac ratio in the assessed trials. Among three SCFAs, the highest impact was observed on acetic acid, followed by propionic acid, and then butanoic acid. The meta-analysis results also obtained sufficient heterogeneity, as indicated by I2 values. There is strong evidence that anthocyanin supplementation improves rodent gut health biomarkers (Fir/Bac and SCFAs), reducing obesity-induced gut dysbiosis, as revealed in this systematic review/meta-analysis. Anthocyanin intervention duration and dosage significantly influenced the Fir/Bac ratio and SCFA. Anthocyanin-rich diets were more effective when consumed over an extended period and at a high dosage.

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Section: Discussionsupporting

confidence: 85%

Effect of anthocyanins on gut health markers, Firmicutes-Bacteroidetes ratio and short-chain fatty acids: a systematic review via meta-analysis

Kapoor

Tiwari

Sharma

et al. 2023

Sci Rep

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“…This finding is consistent with previous reports of cyclophosphamide-induced alterations in the gut microbiota (Xu and Zhang, 2015;Zhang et al, 2020) and may be due to CTX -induced immunodeficiency. Interestingly, the complex probiotic treatment, especially in the CM, CH group, alleviated these imbalances and reduced the proportion of the Firmicutes/Bacteroidetes, which is considered a good indicator of significant changes in microbial composition (Chen et al, 2022;Xie et al, 2022). In addition, at the genus level, CTX reduced the relative abundance of probiotic bacteria such as Bacteroides, Prevotellaceae_ NK3B31, Prevotellaceae_UCG-001, Clostridia, Odoribacter, while the complex probiotics treatment significantly inhibited this trend, which was similar to the results of Zhang et al (2020), who reported that Lactobacillus plantarum BF_15 isolated from the feces of breastfed infants could effectively alleviate CTX-induced immunosuppression by rebalancing the gut microbiota.…”

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confidence: 99%

Immunomodulatory effects of complex probiotics on the immuno-suppressed mice induced by cyclophosphamide

Li²,

Yu³

et al. 2023

Front. Microbiol.

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IntroductionPrevious studies have reported the beneficial effects of Bifidobacterium animalis subsp. lactis XLTG11, Lacticaseibacillus casei Zhang, and Lactiplantibacillus plantarum P8, respectively. However, studies on the immunomodulatory enhancing effects of three complex probiotics have not been conducted. The aim of our study is to investigate the immunomodulatory effects of complex probiotics effect on the immunosuppressed mice induced by cyclophosphamide (CTX).MethodsAn immunocompromised mouse model was established by intraperitoneal injection of cyclophosphamide, which was gavage of different doses of complex probiotics and levamisole hydrochloride. The splenic and thymic indices, intestinal barrier, leukocyte and lymphocyte counts, percentage of splenic lymphocyte subpopulations, cytokine levels, and gut microbiota were determined.ResultsResults showed that the complex probiotics significantly elevated the spleen and thymus indices, increased the villi and crypt depth and the goblet cells. The leukocyte and lymphocyte counts and the percentage of splenic lymphocyte subpopulations in the CTX-treated mice were significantly elevated by the complex probiotics. In addition, the cytokines (IL-6, IL-10, IL-1β, and IFN-γ) were significantly increased after complex probiotic treatment. The complex probiotics restored the gut microbiota structure to the pattern of the control group by reducing the ratio of Firmicutes/Bacteroidetes and enhancing the relative abundances of specific microbiota that produced short-chain fatty acids.DiscussionThis study provides theoretical support for the immunity-enhancing function of the complex probiotics as well as a pharmacological basis for its further development and utilization.

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“…The cooperation between Occludin and ZO-1 plays a key role in maintaining normal TJ structure and intestinal epithelial function. [42] Numerous studies have demonstrated that antioxidants such as procyanidin B2, myricetin, rhein, and quercetin can promote the intestinal barrier function, [23,38,39,[43][44][45][46] but their precise mechanisms are different, interestingly. Pterostilbene improves DSS-induced intestinal epithelial barrier destruction by inhibiting the NF-𝜅B-mediated MLCK-MLC signaling pathway in mice.…”

Section: Discussionmentioning

confidence: 99%

Molecular Mechanisms Associated with Protecting IEC‐6 Cells from Acrylamide‐Induced Tight Junction Damage by Ganoderma atrum Polysaccharide

Yang

Varga

et al. 2023

Molecular Nutrition Food Res

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Scope: The previous in vivo studies show Ganoderma atrum polysaccharide (PSG-F 2 ) has a protective effect against the acrylamide (AA)-induced intestinal oxidative damage in rats. Now, this study aims to explore the protective mechanism with IEC-6 cell model. Methods and results: Based on RNA Sequencing (RNA-Seq), the study screens MAPK signaling pathway as one of the most crucial pathways for pretreatment with PSG-F 2 against AA-induced damage in IEC-6 cells. In total, six key MAPK signaling pathway-related proteins (p-P38/P38, p-ERK/ERK, and p-JNK/JNK), and three tight junction key proteins (Zonula Occludens protein-1, Claudin-1, and Occludin) are detected by Western blot and immunofluorescence, which verify the RNA-Seq data. Moreover, PD98059 interference inhibits critical proteins in the MAPK signaling pathway, thus uncovering the precise molecular mechanisms of MAPK/ERK signaling pathway involve in the protective effects of PSG-F 2 against AA-induced intestinal barrier damage. Conclusion: These findings confirm that PSG-F 2 can be used as a daily dietary supplement to protect the intestinal cells from damage caused by thermal processing hazards AA.

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Purple red rice anthocyanins alleviate intestinal damage in cyclophosphamide-induced mice associated with modulation of intestinal barrier function and gut microbiota

Cited by 39 publications

References 37 publications

Effect of anthocyanins on gut health markers, Firmicutes-Bacteroidetes ratio and short-chain fatty acids: a systematic review via meta-analysis

Effect of anthocyanins on gut health markers, Firmicutes-Bacteroidetes ratio and short-chain fatty acids: a systematic review via meta-analysis

Immunomodulatory effects of complex probiotics on the immuno-suppressed mice induced by cyclophosphamide

Molecular Mechanisms Associated with Protecting IEC‐6 Cells from Acrylamide‐Induced Tight Junction Damage by Ganoderma atrum Polysaccharide

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