Purposing Saikosaponins for the treatment of COVID-19

Bahbah, Eshak I.; Negida, Ahmed; Nabet, Mohamed Salah

doi:10.1016/j.mehy.2020.109782

Cited by 35 publications

(28 citation statements)

References 4 publications

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“…In addition, saikosaponins have great potential in the treatment of COVID-19 through immunomodulatory, anti-inflammatory and antiviral activities. On the one hand, saikossaponins exhibit anti-inflammatory effect by dose-dependently inhibiting the production of several inflammatory mediators which are responsible for the cytokine storm of severe COVID-19 patients, and immunomodulatory effect by inhibiting the proliferation of activated T lymphocytes ( Bahbah et al, 2020 ). On the other hand, it can also directly bind to ACE2 to play the role of anti-SARS-CoV-2 ( Yan Y.-M. et al, 2020 ).…”

Section: Application Of Traditional Chinese Medicine To Prevent and Tmentioning

confidence: 99%

Potential Therapeutic Effect of Traditional Chinese Medicine on Coronavirus Disease 2019: A Review

et al. 2020

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The Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 has been rapidly spreading globally and has caused worldwide social and economic disruption. Currently, no specific antiviral drugs or clinically effective vaccines are available to prevent and treat COVID-19. Traditional Chinese medicine (TCM) can facilitate syndrome differentiation and treatment according to the clinical manifestations of patients and has demonstrated effectiveness in epidemic prevention and control. In China, TCM intervention has helped to control the epidemic; however, TCM has not been fully recognized worldwide. In this review, we summarize the epidemiology and etiological characteristics of severe acute respiratory syndrome coronavirus 2 and the prevention and treatment measures of COVID-19. Additionally, we describe the application of TCM in the treatment of COVID-19 and the identification of small molecules of TCM that demonstrate anti-coronavirus activity. We also analyze the current problems associated with the recognition of TCM. We hope that, through the contribution of TCM, combined with modern technological research and the support of our international counterparts, COVID-19 can be effectively controlled and treated.

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Section: Application Of Traditional Chinese Medicine To Prevent and Tmentioning

confidence: 99%

Potential Therapeutic Effect of Traditional Chinese Medicine on Coronavirus Disease 2019: A Review

et al. 2020

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“…ACE2 is involved in regulating cardiac function and is also a functional receptor for the coronavirus that causes acute respiratory syndrome (SARS). ACE2 receptors are the largest target of SARS-CoV-2 because they play an important role in the transmission of viruses to alveolar cells [ 13 ]. Inhibition or regulation of ACE2 receptors may potentially be effective in the treatment of COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2

et al. 2020

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Over the years, coronaviruses (CoV) have posed a severe public health threat, causing an increase in mortality and morbidity rates throughout the world. The recent outbreak of a novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the current Coronavirus Disease 2019 (COVID-19) pandemic that affected more than 215 countries with over 23 million cases and 800,000 deaths as of today. The situation is critical, especially with the absence of specific medicines or vaccines; hence, efforts toward the development of anti-COVID-19 medicines are being intensively undertaken. One of the potential therapeutic targets of anti-COVID-19 drugs is the angiotensin-converting enzyme 2 (ACE2). ACE2 was identified as a key functional receptor for CoV associated with COVID-19. ACE2, which is located on the surface of the host cells, binds effectively to the spike protein of CoV, thus enabling the virus to infect the epithelial cells of the host. Previous studies showed that certain flavonoids exhibit angiotensin-converting enzyme inhibition activity, which plays a crucial role in the regulation of arterial blood pressure. Thus, it is being postulated that these flavonoids might also interact with ACE2. This postulation might be of interest because these compounds also show antiviral activity in vitro. This article summarizes the natural flavonoids with potential efficacy against COVID-19 through ACE2 receptor inhibition.

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“…The potency of different saikosaponins against different sets of SARS-CoV-2 binding protein via computational molecular docking simulations were evaluated [ 45 ]. Docking studies were carried out on a Glide module of Schrodinger Maestro 2018-1MM Share Version on NSP15 (PDB ID: 6W01) and Prefusion 2019-nCoV spike glycoprotein (PDB ID: 6VSB) from SARS-CoV-2 [ 46 ]. Saikosaponins U ( 9 ) and V ( 10 ) ( Figure 3 ) showed the best affinity towards both the proteins, based on binding energy and interaction data, suggesting them to be molecule of interest as they mark the desire interaction with NSP15, which is responsible for 2019-nCoV spike glycoprotein and the replication of RNA, which manage the connection with ACE2 [ 47 ].…”

Section: Saikosaponinsmentioning

confidence: 99%

“…Saikosaponins U ( 9 ) and V ( 10 ) ( Figure 3 ) showed the best affinity towards both the proteins, based on binding energy and interaction data, suggesting them to be molecule of interest as they mark the desire interaction with NSP15, which is responsible for 2019-nCoV spike glycoprotein and the replication of RNA, which manage the connection with ACE2 [ 47 ]. Additional results indicate that saikosaponin B2 ( 8 ) has potent anticoronaviral activity and that its mode of action possibly involves interference in the early stage of viral replication, such as absorption and penetration of the virus [ 44 , 45 , 46 ].…”

Section: Saikosaponinsmentioning

confidence: 99%

Therapeutic Intervention of COVID-19 by Natural Products: A Population-Specific Survey Directed Approach

et al. 2021

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To date very few promising leads from natural products (NP) secondary metabolites with antiviral and immunomodulatory properties have been identified for promising/potential intervention for COVID-19. Using in-silico docking studies and genome based various molecular targets, and their in vitro anti-SARS CoV-2 activities against whole cell and/or selected protein targets, we select a few compounds of interest, which can be used as potential leads to counteract effects of uncontrolled innate immune responses, in particular those related to the cytokine storm. A critical factor for prevention and treatment of SARS-CoV-2 infection relates to factors independent of viral infection or host response. They include population-related variables such as concurrent comorbidities and genetic factors critically relevant to COVID-19 health disparities. We discuss population risk factors related to SARS-CoV-2. In addition, we focus on virulence related to glucose-6-phosphate dehydrogenase deficiency (G6PDd), the most common human enzymopathy. Review of data on the response of individuals and communities with high prevalence of G6PDd to NP, prompts us to propose the rationale for a population-specific management approach to rationalize design of therapeutic interventions of SARS-CoV-2 infection, based on use of NP. This strategy may lead to personalized approaches and improve disease-related outcomes.

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Purposing Saikosaponins for the treatment of COVID-19

Cited by 35 publications

References 4 publications

Potential Therapeutic Effect of Traditional Chinese Medicine on Coronavirus Disease 2019: A Review

Potential Therapeutic Effect of Traditional Chinese Medicine on Coronavirus Disease 2019: A Review

Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2

Therapeutic Intervention of COVID-19 by Natural Products: A Population-Specific Survey Directed Approach

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