Purpura pigmentosa chronica successfully treated with oral cyclosporin A

Pigmented purpuric dermatoses are a spectrum of disorders characterized by a distinct purpuric rash, mainly localized to the lower limbs, which are morphologically dissimilar but histopathologically indistinguishable. Their etiology remains obscure. They are rather resistant to treatment. Although diagnosed quite straightforwardly, the disease entity remains an enigma and a therapeutic challenge. The current narration discusses the outline of the epidemiology, etiopathogenesis, clinical features, histopathology and management of these disorders. The current review, hopefully, may once again rekindle interest in the entity, for it has been sparingly reported or discussed for the benefit of under- and/or postgraduates and those in practice, including family physicians.

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“…A single case of successful use of cyclosporinee in PPD has been reported, lending credence to the immunological nature of this dermatosis 29 …”

Section: Treatmentmentioning

confidence: 74%

“…28 A single case of successful use of cyclosporinee in PPD has been reported, lending credence to the immunological nature of this dermatosis. 29 Oral rutoside 50 mg twice daily and ascorbic acid 500 mg daily cleared three patients in a trial within 4 weeks. 30…”

Section: Treatmentmentioning

confidence: 99%

Pigmented purpuric dermatoses: An overview

2004

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“…Treatment of PPDs is usually difficult. Various therapeutic options such as oral pentoxifylline, 11 topical steroids, 12 oral rutoside in combination with ascorbic acid, 13 griseofulvin 14 and cyclosporine 15 have been reported to have some efficacy in different forms of PPDs.…”

Section: Discussionmentioning

confidence: 99%

Treatment of pigmented purpuric dermatoses with Narrow‐band UVB: a report of six cases

Fathy¹,

Abdelgaber

2011

Acad Dermatol Venereol

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“…Up until now, topical and oral corticosteroids, oral bioflavonoids, ascorbic acid, griseofulvin, and cyclosporine have been suggested as treatments for chronic pigmented purpura [13, 14]. However, none of these treatments have proven to be satisfactory.…”

Section: Introductionmentioning

confidence: 99%

The Traditional Japanese Formula Keishibukuryogan Inhibits the Production of Inflammatory Cytokines by Dermal Endothelial Cells

Yoshihisa

Furuichi

Rehman

et al. 2010

Mediators of Inflammation

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Keishibukuryogan (KBG) is one of the traditional herbal formulations widely administered to patients with blood stagnation for improving blood circulation; currently, it is the most frequently prescribed medicine in Japan. KBG has been reported to improve conjunctional microcirculation. The aim of this study was to evaluate the role of KBG and paeoniflorin, a bioactive compound of KBG, in inhibiting the production of inflammatory cytokines using human dermal microvessel endothelial cells (HDMECs). The authors observed that lipopolysaccharide (LPS; 1 μg/mL) stimulated the secretion of proinflammatory cytokines in HDMECs. KBG treatment (10 mg/mL) significantly suppressed the mRNA levels of migration inhibitory factor (MIF), interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α in LPS-stimulated cultured HDMECs. Similarly, paeoniflorin significantly suppressed the mRNA levels of these cytokines in LPS-stimulated cultured HDMECs. ELISA showed that KBG and paeoniflorin suppressed the production of MIF, IL-6, IL-8, and TNF-α in LPS-stimulated HDMECs. Moreover, KBG and paeoniflorin decreased the expression of cyclooxygenase-2 and inducible nitric oxide synthase (iNOS) in these cells. These results suggest that KBG may be useful for improving microvascular inflammation in patients with skin diseases.

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Purpura pigmentosa chronica successfully treated with oral cyclosporin A

Cited by 37 publications

References 1 publication

Pigmented purpuric dermatoses: An overview

Pigmented purpuric dermatoses: An overview

Treatment of pigmented purpuric dermatoses with Narrow‐band UVB: a report of six cases

The Traditional Japanese Formula Keishibukuryogan Inhibits the Production of Inflammatory Cytokines by Dermal Endothelial Cells

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