Purpuric Oral and Cutaneous Lesions in a Case of Drug-Induced Thrombocytopenia

Thompson, C.C.; Tacke, Richard B.; Woolley, LeGrand H.; Bartley, Murray H.

doi:10.14219/jada.archive.1982.0337

Cited by 8 publications

(5 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Following withdrawal of both drugs, propranolol (S for CYP1A2, 2C9, 2D6) alone could be resumed without eliciting any reaction. The authors suggested that the reaction was due to an overdose achieved by the combined usage of the two drugs or from disulfiram (I of CYP1A2, 2C9, 2D6, 3A4) subsequent to prior sensitizing exposure to this drug (Thompson et al, 1982). A contribution from drug interactions by inhibition of any of the three implicated CYP enzymes might have been involved in the presumed toxic reaction.…”

Section: Beta-adrenergic Blockers (Babs) (Anti-arrhythmics Class Ii)mentioning

confidence: 99%

Oral Adverse Drug Reactions to Cardiovascular Drugs

Torpet

Kragelund

Reibel

et al. 2004

Critical Reviews in Oral Biology & Medicine

View full text Add to dashboard Cite

A great many cardiovascular drugs (CVDs) have the potential to induce adverse reactions in the mouth. The prevalence of such reactions is not known, however, since many are asymptomatic and therefore are believed to go unreported. As more drugs are marketed and the population includes an increasing number of elderly, the number of drug prescriptions is also expected to increase. Accordingly, it can be predicted that the occurrence of adverse drug reactions (ADRs), including the oral ones (ODRs), will continue to increase. ODRs affect the oral mucous membrane, saliva production, and taste. The pathogenesis of these reactions, especially the mucosal ones, is largely unknown and appears to involve complex interactions among the drug in question, other medications, the patient's underlying disease, genetics, and life-style factors. Along this line, there is a growing interest in the association between pharmacogenetic polymorphism and ADRs. Research focusing on polymorphism of the cytochrome P450 system (CYPs) has become increasingly important and has highlighted the intra-and inter-individual responses to drug exposure. This system has recently been suggested to be an underlying candidate regarding the pathogenesis of ADRs in the oral mucous membrane. This review focuses on those CVDs reported to induce ODRs. In addition, it will provide data on specific drugs or drug classes, and outline and discuss recent research on possible mechanisms linking ADRs to drug metabolism patterns. Abbreviations used will be as follows:

show abstract

Section: Beta-adrenergic Blockers (Babs) (Anti-arrhythmics Class Ii)mentioning

confidence: 99%

Oral Adverse Drug Reactions to Cardiovascular Drugs

Torpet

Kragelund

Reibel

et al. 2004

Critical Reviews in Oral Biology & Medicine

View full text Add to dashboard Cite

show abstract

“…Other causes of senile purpura are nonpathological. Prolonged coughing or vomiting can produce crops of petechiae in loose face and neck tissue 5,7‐8 . Violent muscle contraction, as occurs in seizures or weight lifting, sometimes results in localized ecchymoses due to increased intraluminal pressure and rupture 2‐3 .…”

Section: Discussionmentioning

confidence: 99%

“…Continuous use of certain medications may predispose the patient to damage of the endothelium of small blood vessels or to thrombocytopenia 8,9 . Senile purpura and severe idiopathic thrombocytopenic purpura are side effects related to the ingestion of anticoagulants, such as heparin and warfarin (after 3 to 10 days of drug use), as well as to prolonged use of acetyl salicylic acid, glimepiride, omeprazole, and chlortalidone 9‐11 …”

Section: Introductionmentioning

confidence: 99%

Management of the oral manifestations of senile purpura in an edentulous patient: a case report

Rosa¹,

Garcia²,

Cury³

et al. 2011

Special Care in Dentistry

View full text Add to dashboard Cite

Senile purpura occurs because of a weakness of the vascular supporting tissues mainly caused by aging and is most often seen on the dorsal surface of the hands and the extensor surfaces of the forearms, and has also been observed in the oral mucosa of elderly patients. These red lesions present as sharply margined subcutaneous hemorrhagic spots and are due to trauma, such as damage to the endothelium of small blood vessels, or a coagulation defect. They can also be due to reduced perivascular support, or capillary fragility and permeability, or a combination of all of these factors. Oral manifestation of senile purpura can also be induced by long periods of medication use leading to fragile areas of the mucosa. The presence of senile purpura requires continuous follow-up since drug-induced purpura may cause plaque function alterations. An accurate diagnosis in elderly complete denture wearers can minimize bleeding and prevent possible development of ulcerations under the dentures, especially during the adaptation period to the prosthesis. This case report, presents the care and 3-year follow-up of a 66-year-old woman with complete dentures who presented with the oral manifestations of senile purpura caused by the continued use of several medications.

show abstract

“…Some authors have reported DTC to be immunorestorative (7,8), and/or myeloprotective (9 -11). However, other observations clearly demonstrate that the DTCs are immunosuppressive, both in vivo (12,13) and in vitro (13,14), and are myelotoxic (15)(16)(17)(18). Additionally, bone marrow and hematopoietic toxicity has also been reported as a side effect of many thiono-sulfur-containing compounds (18,19), and suppression of neutrophil, monocyte and platelet counts have been reported following DEDTC treatment of HIV-infected subjects (16).…”

Section: Academic Pressmentioning

confidence: 99%