Purslane protects against the reproductive toxicity of carbamazepine treatment in pilocarpine-induced epilepsy model

Al-Bishri, Widad; Abdel-Reheim, Eman S.; Zaki, Amr R.

doi:10.1016/j.apjtb.2017.01.003

Cited by 13 publications

(4 citation statements)

References 60 publications

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“…Furthermore, purslane protected against reproductive toxicity induced by the anti-epileptic drug, carbamazepine as manifested by restored male fertility hormones and cholesterol level in testis. The latter effect may be due to its hormonal and antioxidant effects [ 22 ]. However, further research is still required to investigate POS’s various male fertility effects and its underlying cellular and molecular mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Portulaca oleracea seeds’ extract alleviates acrylamide-induced testicular dysfunction by promoting oxidative status and steroidogenic pathway in rats

Farag

Abd‐Elsalam

Badawy

et al. 2021

BMC Complement Med Ther

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Background Acrylamide (ACR) is a widespread industrial and food contaminant that garnered considerable attention for its carcinogenic, neurotoxic, and reproductive toxic effects. The antioxidant effects of Portulaca oleracea seeds extract (POS) and its fertility-enhancing effects were inspiring to evaluate the protective potential and pinpoint the mechanisms and molecular targets of the UPLC-MS fingerprinted POS extract on ACR-induced testicular toxicity in rats. Methods Male Wistar rats were divided into 6 equal groups of negative control, ACR model (10 mg/kg b.wt.), POS at doses of (200 and 400 mg/kg b.wt.) and POS-treated ACR groups. All treatments were given by oral dosing every day for 60 days. Results Administration of POS extract reversed the ACR-induced epididymides weight loss with improved semen quality and count, ameliorated the ACR-decreased testicular lesion scoring, testicular oxidative stress, testicular degeneration, Leydig cell apoptosis and the dysregulated PCNA and Caspase-3 expression in a dose-dependent manner. It upregulated the declined level of serum testosterone and the expression of steroidogenic genes such as CYP11A1 and 17β3-HSD with an obvious histologic improvement of the testes with re-establishment of the normal spermatogenic series, Sertoli and Leydig cells. Conclusions The supplementation with POS extract may provide a potential protective effect for ACR-induced testicular dysfunction which is mediated by its antioxidant, antiapoptotic and steroidogenic modulatory effects.

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Section: Introductionmentioning

confidence: 99%

Portulaca oleracea seeds’ extract alleviates acrylamide-induced testicular dysfunction by promoting oxidative status and steroidogenic pathway in rats

Farag

Abd‐Elsalam

Badawy

et al. 2021

BMC Complement Med Ther

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“…Additionally, Azimi et al [ 38 ] showed that the presence of purslane extract reduced the amount of MDA and lipid peroxidation. However, reports have suggested that the antioxidant abilities of plants depend on their phenolic compounds [ 51 ]. Perhaps the reduction of superoxide anion through antioxidant extract supplementation was the main reason for plasma membrane protection against ROS.…”

Section: Discussionmentioning

confidence: 99%

The effects of purslane (Portulaca oleracea) and fennel (Foeniculum vulgare Mill) hydroalcoholic extracts on the functional parameters of human spermatozoa after vitrification

Torkamanpari

Ghorbani

Lorian

et al. 2023

Clin Exp Reprod Med

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Objective: Reactive oxygen species (ROS) are produced during cryopreservation of human sperm and impair sperm function. Antioxidant compounds, such as fennel and purslane, reduce the damaging effects of ROS. This study aimed to evaluate motility parameters, plasma membrane integrity (PMI), mitochondrial membrane potential (MMP), intracellular ROS, and DNA damage to determine the optimum concentrations of hydroalcoholic extracts of fennel and purslane for human spermatozoa cryopreservation. Methods: Twenty human sperm samples were used and divided into seven equal groups consisting of fennel hydroalcoholic extract (5, 10, and 15 mg/L), purslane hydroalcoholic extract (25, 50, and 100 mg/L), and no additive. Results: Supplementation of 25 mg/L and 50 mg/L purslane extract and 10 mg/L fennel extract in cryopreservation extender significantly increased the motility and PMI of sperm with a significant reduction in intracellular ROS compared to control groups (p<0.05). A 50 mg/L concentration of purslane extract elevated progressive motility and MMP compared to the control group (p<0.05). No significant differences were seen for motion patterns and DNA damage of frozen–thawed human sperm in extender containing these extracts. Conclusion: The results showed that supplementation of 50 mg/L purslane extract and 10 mg/L fennel extract in semen cryopreservation extender has the potential to decrease intracellular ROS and subsequently elevate the motility and PMI of human sperm.

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“…Previous findings have likened a decrease concentration of testosterone with the following pathophysiology: 1. an increase in the synthesis of sex hormone‐binding globulin with resultant elevation of estradiol (Herzog, 2002); 2. deregulation of the hypothalamic–pituitary axis in response to increased level of estradiol (Abdel‐Reheim et al., 2008); and 3. lipid peroxidation of testicular tissue, an organ responsible for the synthesis of the androgenic hormone, testosterone synthesis (Al‐Bishri et al., 2017; Herzog, 2008).…”

Section: Discussionmentioning

confidence: 99%

Carbamazepine adversely altered the pituitary–testicular axis with resultant reproductive dysfunctions than levetiracetam or carbamazepine–levetiracetam adjuvant treatment in male Wistar rat

et al. 2020

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This study investigated the on‐toward reactions of individual or adjunctive treatment with carbamazepine (CBZ) and levetiracetam (LEV) on the pituitary–testicular axis in male rats. Twenty‐four male Wistar rats were randomised into 4 groups (n = 6) and received daily intraperitoneal (i.p) treatment of normal saline (0.1 ml/day); CBZ (25 mg/kg i.p); LEV (50 mg/kg i.p); or combination of CBZ (12.5 mg/kg) and LEV (25 mg/kg) for 4 weeks. The serum concentration of luteinising hormone (LH), follicle‐stimulating hormone (FSH), and testosterone was determined. Also, the seminal profile and histomorphological status of the testis were determined. Data were analysed using descriptive and inferential statistics. The control and test groups were compared using Student's t test, analysis of variance (ANOVA), and Student–Newman–Keuls post hoc analysis where appropriate, while the results presented as mean ± SEM in graphs or tables. The level of significance was taken at p < .05. The percentage motility, viability, and concentration of FSH decreased significantly in all the treatment groups, while the testis was presented with various forms of histomorphological aberrations. This study concludes that CBZ, and CBZ + LEV adjunctive treatments alter the pituitary–testicular axis with evidence of hormonal deregulation and alteration in the reproductive functions' indices, while LEV treatment remains the safest.

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Purslane protects against the reproductive toxicity of carbamazepine treatment in pilocarpine-induced epilepsy model

Cited by 13 publications

References 60 publications

Portulaca oleracea seeds’ extract alleviates acrylamide-induced testicular dysfunction by promoting oxidative status and steroidogenic pathway in rats

Portulaca oleracea seeds’ extract alleviates acrylamide-induced testicular dysfunction by promoting oxidative status and steroidogenic pathway in rats

The effects of purslane (Portulaca oleracea) and fennel (Foeniculum vulgare Mill) hydroalcoholic extracts on the functional parameters of human spermatozoa after vitrification

Carbamazepine adversely altered the pituitary–testicular axis with resultant reproductive dysfunctions than levetiracetam or carbamazepine–levetiracetam adjuvant treatment in male Wistar rat

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