“…Within each group, the individual could contract either a viral ARI, susceptible bacterial ARI (sinusitis, otitis media, pharyngitis), or resistant bacterial ARI, due to the most common pathogens associated with these diseases in adults including S. pyogenes (pharyngitis), S. pneumoniae, H. influenzae, and M. catarrhalis (otitis media, sinusitis) and S. aureus in some cases of sinusitis. 20,21 In all three clinical conditions, individuals who received antibiotics were at risk for experiencing drug-associated adverse reactions that either self-resolved or resulted in an emergency department visit and very rarely, death. Severe bacterial ARI was assumed to be one requiring hospitalization regardless of organism susceptibility, with complications such as mastoiditis and brain abscess (acute otitis media), orbital infection (sinusitis), or rheumatic heart disease, tonsillar/retropharyngeal abscess, and glomerulonephritis (pharyngitis).…”