Pushing the resolution of dCas9 barcodes for multiplexed DNA identification with nanopore sensors

Weckman, Nicole E.; Ermann, Niklas; Gutierrez, Richard; Chen, Kaikai; Graham, James E.; Heron, Andrew J.; Keyser, Ulrich F.

doi:10.1109/sensors43011.2019.8956643

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2024

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“…When the single-stranded DNA (ssDNA) enters the nanopore, the flow of ions is blocked by the deoxynucleotide, causing a current drop. Therefore, genetic information on DNA can be read in real time by detecting the ion current or the equivalent conductance of the nanopore in the process [14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

A potentiostat readout array for nanopore-based DNA sequencing

Wang,

Jin,

Tang

et al. 2024

IEICE Electron. Express

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Nanopore-based DNA sequencing technology features the advantages of label-free, low-cost, and rapid detection. However, the existing nanopore sequencing readout cell or array for the lower area and power consumption become prohibitive. This brief presents a low noise potentiostat readout array. Based on the five-transistor OPA, the half-shared amplifier reduces the area and power consumption of the cell by about 50%, and shows a good suppression effect on mid-to-high frequency noise in the output channel. As a result, high-throughput is achieved with low noise. The performance of the proposed array channel has been evaluated in 180-nm CMOS process, the inputreferred current transient noise was 2.28 pARMS, the power consumption was 2.2 µW and the unit area was 10×12 µm 2 .

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