Pustulosis acuta generalisata with joint involvement in an HLA-A2– and HLA-B35–positive patient

Eren, Mittra; Fabri, Mario; Krieg, Thomas; Eming, Sabine A.

doi:10.1016/j.jaad.2008.02.034

Cited by 12 publications

(6 citation statements)

References 8 publications

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“…Our patient presented with a sore throat, oral erosions, and otitis externa with an acute diffuse pustular eruption due to group A β-hemolytic streptococcus that developed 2 days after receiving the second injection of secukinumab. In agreement with the case report by Eren et al ( 4 ), our patient was definitively diagnosed with PAG.…”

Section: Discussionsupporting

confidence: 93%

Case report: Post-streptococcal pustulosis after subcutaneous injection of secukinumab

Lang

Zhang

et al. 2023

Front. Med.

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Section: Discussionsupporting

confidence: 93%

Case report: Post-streptococcal pustulosis after subcutaneous injection of secukinumab

Lang

Zhang

et al. 2023

Front. Med.

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“…Based on these features, we considered that our patient was most likely to have PAG among the group of sterile generalized pustular eruptions. However, the absence of pustules on the palms and soles, and the absence of a streptococcal infection are not in agreement with previous reports on PAG [ 5 6 7 ]. To the best of our knowledge, there are no reports in the English literature of cases with clinical features similar to those of our patient.…”

Section: Discussioncontrasting

confidence: 89%

A Pediatric Case of Acute Generalized Pustular Eruption without Streptococcal Infection

Tabata

Yoshizawa

2016

Case Rep Dermatol

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Generalized pustular lesions characterized by acute onset with fever occur in pustulosis acuta generalisata, acute generalized exanthematous pustulosis, and generalized pustular psoriasis. In the present report, we describe a pediatric case of generalized pustular eruption that was not completely consistent with clinical features. Our patient had no evidence of a post-streptococcal infection. We observed scattered symmetric eruption of discrete pustules with an inflammatory halo on normal skin. The eruption was absent on her palms and soles of the feet. To the best of our knowledge, there are no reports in the English literature of cases with clinical features similar to those of our patient.

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“…The most important disease, and sometimes difficult to be differentiated, is acute generalized pustular bacterid (AGPB) (pustulosis acuta generalisata), which is characterized by widespread, scaly erythemas including sterile pustules affecting the hands, feet, extremities and trunk . AGPB is most frequently induced by streptococcal infection, accompanied by general symptoms such as fever, arthralgia, increased levels of erythrocyte sedimentation rate and C‐reactive protein.…”

Section: Differential Diagnosismentioning

confidence: 99%

Pustulotic arthro‐osteitis associated with palmoplantar pustulosis

Yamamoto

2013

The Journal of Dermatology

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Palmoplantar pustulosis (PPP) is a chronic inflammatory disorder characterized by sterile pustules predominantly involving the palms and soles of middle-aged women. PPP frequently develops or exacerbates following focal infections, such as tonsillitis, odontogenic infection and sinusitis, either with or without arthralgia and/or extra-palmoplantar lesions. Pustulotic arthro-osteitis (PAO) is a joint comorbidity of PPP, most often affecting the anterior chest wall. PAO is sometimes regarded as the same entity as synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome, and may be a subtype or incomplete type of SAPHO syndrome; however, there are several differences. In Japanese patients, PPP with PAO is frequently seen, whereas SAPHO syndrome in the true meaning is rare. A difference of incidence depending on race suggests that different genetic backgrounds may be responsible for susceptibility to these disorders. Bacterial infection, especially Propionibacterium acnes, is suggested to play an important role in the pathogenesis of SAPHO syndrome. P. acnes is responsible for acne, however, bacterium is unassociated with PPP skin lesions which are characterized by sterile pustules. On the other hand, PAO is frequently triggered by focal infection, and treatment of focal infection results in dramatic effects on the release of joint pain. This paper reviews current insights into the clinicopathophysiology of PAO, and discusses its possible mechanisms in comparison with SAPHO syndrome.

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Pustulosis acuta generalisata with joint involvement in an HLA-A2– and HLA-B35–positive patient

Cited by 12 publications

References 8 publications

Case report: Post-streptococcal pustulosis after subcutaneous injection of secukinumab

Case report: Post-streptococcal pustulosis after subcutaneous injection of secukinumab

A Pediatric Case of Acute Generalized Pustular Eruption without Streptococcal Infection

Pustulotic arthro‐osteitis associated with palmoplantar pustulosis

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