Pustulosis Palmaris Et Plantaris Due to Tonsillar Focal Infections: From the Analysis of Long-term Observed Cases

Noda, Yutaka; Ura, Masaharu

doi:10.3109/00016488309121154

Cited by 20 publications

(11 citation statements)

References 12 publications

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“…The Japanese study was performed on patients attending hospital clinics on account of PPP, whereas the present patients were seen by general practitioners. However, the F/M ratio of similar groups of hospital patients with PPP is about three times lower in Japanese than in Scandinavians, being 0.8-1.6 and 2.3-7.7, respectively [7,14,16,17,32,45,47]. Thus there is at least a sex difference between Japanese and Scandinavians with PPP, and ethnic differences may also play a part.…”

Section: Discussionmentioning

confidence: 91%

Anterior chest wall involvement in patients with pustulosis palmoplantaris

Jurik¹

1990

Skeletal Radiol.

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With the aim of determining the frequency and radiographic features of anterior chest wall involvement in patients with pustulosis palmoplantaris, a questionnaire was sent to 107 patients. Ninety-three patients returned the questionnaire, five of whom were excluded from further analysis due to the appearance of psoriatic lesions. Twenty-five (28%) of the remaining 88 patients reported pain and/or swelling of joints or bones in the anterior chest wall. All were examined radiographically, using tomography, and a group of 20 patients without anterior chest wall complaints were examined similarly. Sixteen of the patients with, but none of the patients without, complaints were found to have arthro-osteitis of the anterior chest wall, consisting of diffuse sclerosis of the manubrium sterni in one patient, localized sclerosis in seven patients, and sequelae of arthritis of the sternoclavicular, upper sternocostal and/or manubriosternal joint in eight patients.

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Section: Discussionmentioning

confidence: 91%

Anterior chest wall involvement in patients with pustulosis palmoplantaris

Jurik¹

1990

Skeletal Radiol.

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“…PPP is regarded as a common skin disease that is often recalcitrant to treatments and recurs frequently. There have been numerous reports on the associations of PPP with gender, smoking, thyroid gland dysfunction and focal infections . Several reports have shown pathophysiological associations between PPP and the levels of cytokines such as interleukin (IL)‐8 and IL‐17 .…”

Section: Introductionmentioning

confidence: 99%

The microbiome of the “sterile” pustules in palmoplantar pustulosis

Masuda-Kuroki

Murakami

Tokunaga

et al. 2018

Experimental Dermatology

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The skin microbiome influences skin pathophysiology. Palmoplantar pustulosis (PPP) is a chronic skin disease characterized by infectious‐like pustules on the palms and soles. These pustules are thought to be sterile because bacterial cultures obtained from the pustules are negative. However, culture methods are limited in their ability to identify all bacteria on the skin. We hypothesized that the “sterile” pustules of PPP do not lack bacteria, but rather contain a microbiome. To test this hypothesis, we identified bacteria in “sterile” pustules using non‐culture methods. We conducted Sanger and 16S rRNA sequencing using primers specific to the V1‐V2 region in PPP‐pustulovesicles (PVs) (n = 43) and pompholyx vesicle fluids (n = 15). Sanger sequencing identified some Staphylococcus, Propionibacterium, Streptococcus and Pyrinomonas species in PPP‐PVs but failed to identify any bacteria in most of the pompholyx vesicles. 16S rRNA sequencing of PPP‐PVs indicated the presence of a microbiome that included various phyla, including Firmicutes, Proteobacteria, Actinobacteria and Bacteroidetes. At the genus level, smokers had higher levels of Staphylococcus in PPP‐PVs compared with non‐smokers. These results indicate that a microbiome exists in “sterile” pustules of PPP and that PPP smokers had higher levels of Staphylococcus in pustules. It is therefore necessary to reconsider the pathogenesis of PPP from the perspective of the microbiome.

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“…In the light of modern immunology, secondary disorders caused by focal infection of the tonsils may be considered in the category of autoimmune diseases. Pustulosis palmaris et plantaris (PPP) is a chronic recurrent disorder of the palms and soles characterized by sterile intradermal postules (Ofuji et al, 1958;Thomsen and Österbye, 1973;Noda and Ura, 1983). PPP affects women slightly more frequently than men between the ages of 30 and 60 years.…”

Section: Tonsils As a Putative Source Of Autoantibodiesmentioning

confidence: 98%

Immunobiology of the Tonsils and Adenoids

Brandtzæg

2015

Mucosal Immunology

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Pustulosis Palmaris Et Plantaris Due to Tonsillar Focal Infections: From the Analysis of Long-term Observed Cases

Cited by 20 publications

References 12 publications

Anterior chest wall involvement in patients with pustulosis palmoplantaris

Anterior chest wall involvement in patients with pustulosis palmoplantaris

The microbiome of the “sterile” pustules in palmoplantar pustulosis

Immunobiology of the Tonsils and Adenoids

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