Pustulosis palmoplantaris is a disease distinct from psoriasis

Waal, Anne C de; Kerkhof, Peter C M van de

doi:10.3109/09546631003636817

Cited by 79 publications

(87 citation statements)

References 25 publications

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“…Histologically, PPP shows an intra-epidermal collection of neutrophils and a mixed perivascular and diffuse infiltrate of inflammatory cells in the upper dermis. The relationship between PPP and psoriasis is still under investigation (8). Patients with PPP may have extra-palmoplantar lesions that resemble psoriasis.…”

Section: Resultsmentioning

confidence: 99%

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Tonsillectomy as a treatment for psoriasis: A review

Debbaneh

Moslehi

et al. 2013

Journal of Dermatological Treatment

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Psoriasis is a chronic skin disorder that affects 1% to 3% of the general population worldwide. Streptococcal infection, especially streptococcal pharyngitis, has been shown to be a significant trigger of psoriasis in some patients, possibly by sensitizing T cells to keratin epitopes in the skin. Due to the role of the palatine tonsils as an immunological organ that may generate autoreactive T cells, tonsillectomy has been investigated as a treatment for psoriasis. Tonsillectomy originally gained acceptance in Japan as a treatment for palmoplantar pustulosis, a condition that shares features with pustular psoriasis. Subsequently, tonsillectomy has been used for the treatment of plaque psoriasis and guttate psoriasis. Recently, the first randomized, controlled clinical trial of tonsillectomy was performed. Here, we review the available evidence for the benefit of tonsillectomy as a treatment for palmoplantar pustulosis and psoriasis. We also discuss molecular studies aimed at understanding the role of tonsils in skin disease.

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Section: Resultsmentioning

confidence: 99%

“…This provides a biologically plausible model for the benefit of tonsillectomy in PPP. There is debate as to whether PPP is related to psoriasis or represents a distinct clinical entity (8). Rare variants in IL36RN gene have been identified in both PPP and generalized pustular psoriasis (GPP) (9).…”

Section: Discussionmentioning

confidence: 99%

Tonsillectomy as a treatment for psoriasis: A review

Debbaneh

Moslehi

et al. 2013

Journal of Dermatological Treatment

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“…It is often distinguished from PAO with an erosive course and polyarticular joint involvement, including proximal and distal interphalangeal, metacarpophalangeal, metatarsofalangeal, ankle, and wrist joints. In addition, PPP, which is a skin lesion of PAO, has been reported to be a variation of pustular psoriasis and reported conversely that these two diseases are different clinical entities [5,6]. Mejjad et al [3] reported a prospective study with 23 PsA and 23 PAO patients.…”

Section: Discussionmentioning

confidence: 99%

“…In majority of patients, skin lesions occur concurrently with joint involvement, but the intervals may also vary between the onset of the symptoms [1][2][3][4]. Skin findings of the disease are accepted as a variant of pustular psoriasis, but some authors have suggested that PPP is a different entity [5,6]. Although the PAO has earlier been included in psoriatic arthropathies (PsA), it also differs from PsA in the joint involvement pattern.…”

Section: Introductionmentioning

confidence: 99%

Pustulotic Arthro-Osteitis (Sonozaki Syndrome): A Case Report and Review of Literature

et al. 2018

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Pustulotic arthro-osteitis (PAO) is a rare chronic inflammatory disease, which has now been classified as a seronegative spondyloarthritis. The sternoclavicular and sternocostal joints, pelvis, vertebra, hip, and long bones are affected. Skin findings of the disease are accepted as a variant of pustular psoriasis, but some authors have suggested that palmoplantar pustulosis (PPP) is a different entity. The synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome should be considered in the differential diagnosis. PAO differs from SAPHO by the absence of hyperostosis and the difference in skin manifestations. Here, we aimed to present a 34-year-old female patient with a diagnosis of PAO with typical skin findings and joint involvement.

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“…Palmoplantar pustulosis is frequently associated with classic psoriasis vulgaris, but it is now believed that it may not be a form of psoriasis [2,3]. …”

Section: Introductionmentioning

confidence: 99%

Randomized, Within-Patient, Clinical Trial Comparing Fluorine-Synthetic Fiber Socks with Standard Cotton Socks in Improving Plantar Pustulosis

et al. 2014

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Background/Aims: Rubbing the skin may influence the persistence of pustulosis over time. The aim of this study was to assess the impact of a new fabric made with fluorine-synthetic fiber in improving plantar pustulosis. Methods: A total of 17 patients were randomized to receive on one side a sock made of fluorine-synthetic fiber and on the other a sock made of cotton fabric for 4 weeks. The main outcome was the percentage reduction of lesional area at week 4. Results: The median lesion reduction at week 4 was 42.6% in the fluorine-synthetic fiber arm and 2.7% in the cotton arm (p = 0.148). Among secondary outcomes, the overall reduction over time in the treated areas was significantly in favor of the fluorine-synthetic fiber arm (p = 0.045) as well as the perception of the disease by the patient (p = 0.025). Conclusion: Despite the fact that the primary outcome was not reached, there was a tangible reduction in the extension of the treated areas and in the perception of the disease by the patient.

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Pustulosis palmoplantaris is a disease distinct from psoriasis

Cited by 79 publications

References 25 publications

Tonsillectomy as a treatment for psoriasis: A review

Tonsillectomy as a treatment for psoriasis: A review

Pustulotic Arthro-Osteitis (Sonozaki Syndrome): A Case Report and Review of Literature

Randomized, Within-Patient, Clinical Trial Comparing Fluorine-Synthetic Fiber Socks with Standard Cotton Socks in Improving Plantar Pustulosis

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