Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection

Cruz, Miguel Meira e; Miyazawa, Masaaki; Gozal, David

doi:10.1183/13993003.01023-2020

Cited by 56 publications

(34 citation statements)

References 59 publications

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“…Moreover, this relationship might also be an effect of a more intensive workload during night shifts. Alternately, since lung expression of ACE2 will also manifest circadian changes through cell-autonomous regulations and indirect effects of circadian changes in the renin-angiotensin system, it is conceivable the rhythmic expression of clock genes (Per2, Rev-ERBα, and BMAL1), frequently disrupted in sleep disturbances, may be involved in SARS-Cov-2 infection [11]. As previously reported, our results depict hypertension as the most prevalent comorbidity in the adult population with COVID-19 [12].…”

Section: Discussionmentioning

confidence: 99%

High body mass index and night shift work are associated with COVID-19 in health care workers

Rizza

Coppeta

Grelli

et al. 2020

J Endocrinol Invest

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Objective To assess the magnitude of COVID-19 spread and the associated risk factors among health care workers (HCWs), we conducted an in-hospital survey in a central Italian COVID Hospital. Methods Participants underwent nasopharyngeal swab and/or serum collection for SARS-CoV-2 IgG examination. We divided participants according to working status, into rotating-night shift workers (r-NSW) and day-workers. Results We found 30 cases of COVID-19 infection in a total of 1180 HCWs (2.5%). Most COVID-19-positive hospital employees were r-NSWs with significantly higher BMI than that of individuals who tested negative. After adjustment for covariates, night work and BMI > 30 were associated with a markedly greater risk of COVID-19 diagnosis (OR 3.049 [95%CI 1.260-7.380] and OR 7.15 [95%CI 2.91-17.51], respectively). Conclusions Our results describe a low prevalence of COVID-19 infection among HCWs at a central Italian COVID Hospital. COVID-19 infection risk appears to be associated with obesity and night shift work, thus supporting the need for careful health surveillance among frontline HCWs exposed to COVID-19.

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Section: Discussionmentioning

confidence: 99%

High body mass index and night shift work are associated with COVID-19 in health care workers

Rizza

Coppeta

Grelli

et al. 2020

J Endocrinol Invest

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“…Une détérioration de la qualité du sommeil en confinement est un constat important, surtout pour les personnes qui dorment moins : le sommeil joue un rôle important dans les défenses immunitaires. Une revue récente conclut que non seulement le risque d'infection, mais aussi la sévérité de l'infection par le SARS-CoV-2 sont influencées par la qualité du sommeil [34], d'où l'importance de maintenir un sommeil de qualité en confinement.…”

Section: Discussionunclassified

Les effets de confinement SARS-CoV-2 sur le sommeil : enquête en ligne au cours de la quatrième semaine de confinement

Hartley

Francs²,

Aussert

et al. 2020

L'Encéphale

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Mots clés : Sommeil Confinement COVID 19 « Jet-lag » social Habitudes de sommeil r é s u m é Objectif.-Déterminer l'évolution du sommeil chez les Franç ais pendant le confinement motivé par la pandémie du SARS-CoV-2 et définir les facteurs comportementaux associés à un sommeil détérioré. Méthodologie.-Une enquête en ligne via les réseaux sociaux pendant la période de confinement. Les questions ont ciblé les conditions de confinement, les comportements relatifs au sommeil et les éléments de l'environnement potentiellement perturbateurs du sommeil (exposition à la lumière et activités sportives). Résultats.-Au total, 1777 participants ont été inclus dont 77 % femmes, 72 % âgés de 25-54 ans. Les conditions de confinement les plus fréquentes étaient en couple avec enfants (36 %) et en maison avec jardin (51 %). Quarante-sept pour cent rapportent une diminution de la qualité du sommeil en confinement. Les facteurs associés à une détérioration du sommeil retenus par l'analyse multivariée sont une diminution de la durée du sommeil (OR 15,52-p < 0,001), un coucher plus tardif (OR 1,72-p < 0,001), un lever plus matinal (2,18-p = 0,01), des horaires plus irréguliers (OR 2,29-p < 0,001), une diminution de l'exposition à la lumière du jour (OR 1,46-p = 0,01) et une augmentation de l'utilisation des écrans le soir (OR 1,33-p = 0,04). Conclusion.-La mauvaise qualité subjective du sommeil en confinement est associée à une modification des comportements relatifs au sommeil et de l'exposition à la lumière (moins de lumière du jour et plus d'écran le soir). Pour optimiser le sommeil en confinement, des horaires adaptés et réguliers, une exposition de plus d'une heure/jour à la lumière du jour et l'éviction des écrans le soir sont à conseiller.

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“…Indeed, it is well-documented that good sleep quality and normal function of the immune system are strongly related. In this context, Meira e Cruz et al have recently reviewed the potential links between SARS-Cov-2 infection, circadian rhythms, and sleep [9]. Although it is unclear how disrupted or insufficient sleep may affect SARS-Cov2 infection rates and the severity of its clinical manifestations, these authors suggested that the immuno-inflammatory activation that typically occurs in lung injury induced by COVID-19 may be influenced by the circadian clock [9].…”

Section: Clinical Evidences: Our Experiencementioning

confidence: 99%

“…In this context, Meira e Cruz et al have recently reviewed the potential links between SARS-Cov-2 infection, circadian rhythms, and sleep [9]. Although it is unclear how disrupted or insufficient sleep may affect SARS-Cov2 infection rates and the severity of its clinical manifestations, these authors suggested that the immuno-inflammatory activation that typically occurs in lung injury induced by COVID-19 may be influenced by the circadian clock [9]. It is speculative that deregulation of circadian rhythms such as that occurs in night shift workers or with jetlag could play a disease-specific role by altering the susceptibility to infection or modifying the clinical manifestations of COVID-19 [9].…”

Section: Clinical Evidences: Our Experiencementioning

confidence: 99%

COVID-19 and Sleep in Medical Staff: Reflections, Clinical Evidences, and Perspectives

Ferini‐Strambi

Zucconi

Salsone

2020

Curr Treat Options Neurol

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Purpose of the review There is evidence that, before the coronavirus pandemic 2019 (COVID-19), healthcare workers did not experience good sleep quality with relevant consequences on health. By contrast, little is known about the sleep quality of medical staff during the COVID-19 pandemic. In this review, we aimed to contribute with a review of the literature, sharing our clinical experience supported by actigraphic evaluation and by proposing future strategies. Recent findings Sleep disorders, in particular insomnia, have been commonly reported in frontline medical workers, in hospitals during the COVID-19 pandemic and are often accompanied by depressive and anxiety symptoms. Sleep quality, however, has been mainly assessed by the use of self-reported measures, thus limiting clinical usefulness. Summary Poor sleep quality among the medical staff is prevalent, and our experience supports that this has increased during the COVID-19 pandemic. A longitudinal investigation assessing whether and for how long sleep remains altered in medical staff could be of interest to evaluate the temporal effect of the pandemic on health.

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Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection

Cited by 56 publications

References 59 publications

High body mass index and night shift work are associated with COVID-19 in health care workers

High body mass index and night shift work are associated with COVID-19 in health care workers

Les effets de confinement SARS-CoV-2 sur le sommeil : enquête en ligne au cours de la quatrième semaine de confinement

COVID-19 and Sleep in Medical Staff: Reflections, Clinical Evidences, and Perspectives

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