Putative mechanisms for spread and transformation of cutaneous T‐cell lymphoma to neurolymphomatosis

Abstract

Inherited Neuropathies Consortium natural history study: a crosssectional analysis.

Neurolymphomatosis related to direct epineural invasion of the superficial peroneal nerve from subcutaneous B-cell lymphoma

“…Considering the very superficial localization of SPN, direct epineural invasion by monoclonal cells from subcutaneous tissue seems possible, as it has been previously hypothesized in T-cell lymphoma. 6 Pathogenesis of neurolymphomatosis might be even more complex and new mechanisms might be elucidated in the future, as evidenced by a recent study showing a potential role of the extracellular matrix in malignant lymphoproliferation. 7 Nerve biopsy also showed necrotizing vasculitis, which is not reported in neurolymphomatosis.…”

A novel mechanism for the formation and propagation of neural tumors and lesions through neural highways

“…We discovered perineural spread along extensive neural highways from malignant peripheral nerve sheath tumors (MPNSTs) (Gilder et al, 2018;Puffer et al, 2018), neurolymphomatosis (Capek et al, 2015c;Crush et al, 2014;DeVries et al, 2019;Ghobrial et al, 2004;Khurana et al, 2021;Murthy et al, 2020;Murthy et al, 2020a;Puffer et al, 2019), neuroleukemiosis (Reddy et al, 2012), and Pancoast tumors or other lesions invading into the brachial plexus (Murthy et al, 2020b). Furthermore, infectious etiologies, including mucormycosis or herpes zoster, also use these neural pathways for perineural spread.…”