Putative mechanisms Underlying Myocardial infarction onset and Emotions (PUME): a randomised controlled study protocol

Ensari, Ipek; Burg, Matthew M.; Diaz, Keith M.; Fu, Jie; Duran, Andrea T.; Suls, Jerry; Sumner, Jennifer A.; Monane, Rachel; Julian, Jacob; Shuqing, Zhao; Chaplin, William F.; Shimbo, Daichi

doi:10.1136/bmjopen-2017-020525

Cited by 4 publications

(5 citation statements)

References 96 publications

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“…This shows that pregnant women who were reported to have had anxiety level 4 (highest) both at crude and adjusted odds ratios reduced their odds of developing haemorrhage by 20.6% and 19.1% respectively compared with those who were not anxious. The protective effect observed in this study is quiet in contrast with the findings of other studies [46] where the effects of sadness and anxiety may cause impaired endothelial cell function leading to the development of atherosclerosis which can led to PE-E and this can also led to haemorrhage.…”

Section: Discussioncontrasting

confidence: 99%

Effects of Pregnancy-Induced Psychological and Emotional Factors on the Occurrence of Preeclampsia/Eclampsia (PE-E) and Haemorrhage

Avoka¹

2022

TIJPH

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Preeclampsia/eclampsia (PE-E) and haemorrhage are the topmost causes of maternal and perinatal deaths in the world. This study was designed to assess the effects of pregnancy-induced psychological and emotional factors on the occurrence of PE-E and haemorrhage. The study was a prospective cohort involving all pregnant women >28 weeks of gestation reporting for antenatal care (ANC) in seven Hospitals in the Eastern Region of Ghana. The study redesigned the Revised Cognitive Therapy Scale (CTS-R) to suit this study using a five-point score scale. The results show that the predictor variables; fear, anger, sadness, disgust, love, hate, tension, anxiety, depression, and dejection, were all statistically significant and associated with PE-E and haemorrhage except joy, acceptance, and happiness. Pregnant women who experienced high (2) and highest (4) levels of fear had reduced odds of PE-E by 34% and 15.8%, respectively. Those who recorded low levels of love were 9.8 times the odds of PE-E, those with low (1), high (2), higher (3), and highest (4) levels of anxiety had reduced odds of PE-E by 22.2%, 37.3%, 21.3%, and 10% respectively. Pregnant women with low levels of psychological and emotional issues were about 3 times the odds of PE-E compared to those who were normal. In conclusion, the study shows a significant association between preeclamptic/eclamptic pregnant women and different levels of fear, anger, sadness, Love, hate, depression, dejection, anxiety, and tension. It is recommended that Ghana Health Service should institute psychological and emotional counselling as part of ANC services in order to manage pregnant women who may need them to avert the effects on pregnancy and birth outcome.

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Section: Discussioncontrasting

confidence: 99%

Effects of Pregnancy-Induced Psychological and Emotional Factors on the Occurrence of Preeclampsia/Eclampsia (PE-E) and Haemorrhage

Avoka¹

2022

TIJPH

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“…We conducted the National Heart, Lung, and Blood Institute‐funded PUME (Putative Mechanisms Underlying Myocardial Infarction Onset and Emotions) study, which was a laboratory‐based, randomized controlled experimental study. 21 The PUME study was a single‐blind, between‐subjects (ie, parallel arm) randomized study design in which 280 participants, enrolled from August 2013 to May 2017, were randomized to 1 of the 4 conditions: an anger recall task, an anxiety recall task, a depressed mood recall task, and an emotionally neutral condition ( Clinicaltrials.gov registration number: NCT01909895). Pre‐/post‐assessments of EC health using flow‐mediated EDV, EC injury as represented by levels of circulating EC‐derived microparticles (EMPs), and EC reparative capacity as represented by levels of circulating bone marrow‐derived endothelial progenitor cells (EPCs) were conducted.…”

Section: Methodsmentioning

confidence: 99%

“…The prior study protocol 21 and Data S1 describe the study protocol in detail. In brief, information about participant demographics and cardiovascular risk factors were obtained by self‐administered standardized questionnaires and interview during the screening visit.…”

Section: Methodsmentioning

confidence: 99%

“…Afterwards, a finger probe for the EndoPAT2000 device (Itamar Medical, Inc; ZOLL Medical Corporation) was placed on the first digit of each hand for the assessment of EDV. 21 A BP cuff was placed on the nondominant forearm for inducing reactive hyperemia for EDV testing. The participant was then instructed to relax for 30 minutes, during which they were not allowed to talk, use their phones, read any documents, or sleep.…”

Section: Methodsmentioning

confidence: 99%

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Translational Research of the Acute Effects of Negative Emotions on Vascular Endothelial Health: Findings From a Randomized Controlled Study

Shimbo,

Cohen,

McGoldrick

et al. 2024

JAHA

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Background Provoked anger is associated with an increased risk of cardiovascular disease events. The underlying mechanism linking provoked anger as well as other core negative emotions including anxiety and sadness to cardiovascular disease remain unknown. The study objective was to examine the acute effects of provoked anger, and secondarily, anxiety and sadness on endothelial cell health. Methods and Results Apparently healthy adult participants (n=280) were randomized to an 8‐minute anger recall task, a depressed mood recall task, an anxiety recall task, or an emotionally neutral condition. Pre−/post‐assessments of endothelial health including endothelium‐dependent vasodilation (reactive hyperemia index), circulating endothelial cell‐derived microparticles (CD62E+, CD31+/CD42−, and CD31+/Annexin V+) and circulating bone marrow‐derived endothelial progenitor cells (CD34+/CD133+/kinase insert domain receptor+ endothelial progenitor cells and CD34+/kinase insert domain receptor+ endothelial progenitor cells) were measured. There was a group×time interaction for the anger versus neutral condition on the change in reactive hyperemia index score from baseline to 40 minutes ( P =0.007) with a mean±SD change in reactive hyperemia index score of 0.20±0.67 and 0.50±0.60 in the anger and neutral conditions, respectively. For the change in reactive hyperemia index score, the anxiety versus neutral condition group by time interaction approached but did not reach statistical significance ( P =0.054), and the sadness versus neutral condition group by time interaction was not statistically significant ( P =0.160). There were no consistent statistically significant group×time interactions for the anger, anxiety, and sadness versus neutral condition on endothelial cell‐derived microparticles and endothelial progenitor cells from baseline to 40 minutes. Conclusions In this randomized controlled experimental study, a brief provocation of anger adversely affected endothelial cell health by impairing endothelium‐dependent vasodilation.

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“…Healthy adult participants were enrolled into the Putative Mechanisms Underlying Myocardial Infarction Onset and Emotions (PUME) study, a laboratory-based, single-blind, randomized controlled experimental study conducted from August 2013 to May 2017 (N=280). As described elsewhere in detail, PUME was designed to examine the impact of negative emotion (i.e., anger, anxiety and sadness) induction tasks on EC health (14). Inclusion criteria included adults ≥18 years of age.…”

Section: Study Participantsmentioning

confidence: 99%

Associations between Habitual Sedentary Behavior and Endothelial Cell Health

et al. 2020

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Endothelial dysfunction is a mechanism that may explain the link between prolonged sedentary time and cardiovascular disease. However, the relation between habitual sedentary behavior (SED) and endothelial function has yet to be explored.Purpose--The purpose of this study was to examine the association of accelerometer-measured SED with markers of endothelial cell health.Methods--Healthy adult participants (n=83; 43.4% male; 25.5 ± 5.8 years old) were examined. SED was measured for 7-days by accelerometer. Endothelial function measures included endothelium-dependent vasodilation (EDV); endothelial microparticles (EMPs) [CD62E+ and CD31+/CD42− EMPs]; and endothelial progenitor cells (EPCs) [CD34+/CD133+/KDR+ and CD34+/KDR+EPCs]. Participants were classified as having low or high SED based on a median split.Results--Participants in the low and high SED group spent a mean ± SD of 8.6 ± 1.1 and 11.1 ± 1.0 h/day in SED, respectively. No significant differences between the low and high SED groups were detected in mean [95% confidence interval (CI)] EDV (2.

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Putative mechanisms Underlying Myocardial infarction onset and Emotions (PUME): a randomised controlled study protocol

Cited by 4 publications

References 96 publications

Effects of Pregnancy-Induced Psychological and Emotional Factors on the Occurrence of Preeclampsia/Eclampsia (PE-E) and Haemorrhage

Effects of Pregnancy-Induced Psychological and Emotional Factors on the Occurrence of Preeclampsia/Eclampsia (PE-E) and Haemorrhage

Translational Research of the Acute Effects of Negative Emotions on Vascular Endothelial Health: Findings From a Randomized Controlled Study

Associations between Habitual Sedentary Behavior and Endothelial Cell Health

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