Putative Role of MCT1 rs1049434 Polymorphism in High-Intensity Endurance Performance: Concept and Basis to Understand Possible Individualization Stimulus

Abstract

Monocarboxylate transporters (MCTs) have been proposed as important mediators of the exchange between lactate (La−) producer and La− recipient (consumer) cells. Previous studies have suggested that the MCT1 A1470T genotype could be related to different physical performance phenotypes. This study followed the guidelines for Strengthening the Reporting of Genetic Association Studies (STREGA) and aimed to evaluate the distribution of the MCT1 polymorphism rs1049434 in endurance-trained athletes compared to the untrained population. Moreover, this study explored the potential influence of the polymorphism alleles phenotypes on high-intensity exercise performance. In a cross-sectional study fashion, a total of 85 triathletes from northern Spain were genotyped for MCT1 rs1049434 and compared to a control group of 107 healthy male participants (1000 Genomes Research Study for Iberian Populations in Spain). All athletes performed a 30 s Wingate all-out test (WAnT) on a cycle ergometer. Peak and mean power (absolute and relative) were measured. After verification of the Hardy–Weinberg equilibrium, the findings indicated that the MCT1 TT genotype was overrepresented in triathletes in comparison to the genotypic frequency of the general Spanish population. No significant associations were found between any MCT1 genotype and peak or mean power performance in the WAnT. Further studies are required to understand the relationship among MCT1 A1470T polymorphism, endurance-trained athletes, and high-intensity performance.

Examining the relationship between genetic polymorphisms (BDKRB2, GNB3, HIF1A, MCT1, NOS3) and endurance athlete status

“…Similar findings have been reported in other studies, where the MCT1 major (T) allele was associated with endurance athlete status and athletic performance (Guilherme et al 2021 ; Saito et al 2021 ). In a study by Piscina-Viúdez et al ( 2021 ), although no statistically significant association was found between athletic performance and the MCT1 gene, the MCT T/T genotype was observed to be higher in triathletes compared to the control group. In another study comparing swimmers and runners, it was reported that the frequency of the T allele was higher in swimmers than in runners (Ben-Zaken et al 2015 ).…”

“…From 7 articles that met the inclusion criteria related to MCT1 gene polymorphism, 1392 endurance athletes and 3834 controls have been included in the study (Ben Zaken et al 2015 ; Dzitkowska-Zabielska et al 2022 ; Fedotovskaya et al 2014 ; Guilherme et al 2021 ; Piscina-Viúdez et al 2021 ; Saito et al 2021 ; Sawczuk et al 2015 ). When analyzing the MCT1 (rs1049434) SNP genotypes, the overall analysis showed that endurance athletes [OR: 0.17 [0.02; 0.32]] and Caucasian athletes in the subgroup [OR: 0.42 [0.26; 0.58]] had a higher frequency of the T/T genotype ( p < 0.05).…”

Unraveling the gut health puzzle: exploring the mechanisms of butyrate and the potential of High-Amylose Maize Starch Butyrate (HAMSB) in alleviating colorectal disturbances

“…This indicates that a lower dose of butyrate supplementation at around 3.4 g/d might be optimal. Notably, individual variance may exist in the capability of absorbing SCFAs, as recent studies have identified polymorphisms in several SCFA transporters including MCT1 and MCT2 genes ( 135 , 136 ). As mentioned in Section 2, the fermentation of 1 g fiber may correspond to the production of 10 mM SCFAs.…”

Examining the Interaction between Exercise, Gut Microbiota, and Neurodegeneration: Future Research Directions

“…Interestingly, La − disposal, production, and transportation are not only regulated by extrinsic factors such as exercise dose and energy intake (i.e., distal physiology) but also by intrinsic factors like genetic variations in La − -related genes (MCTs) and the microbiota status [ 52 , 53 ]. In recent years, this direct interaction between La − levels and the microbiota status has been reported in different phenotypes, including the obese population and highly trained athletes [ 54 , 55 , 56 ].…”