Putrescine (1,4-Diaminobutane) enhances antifungal activity in postharvest mango fruit against Colletotrichum gloeosporioides through direct fungicidal and induced resistance mechanisms

Song, Yaping; Ren, Yulong; Xue, Yuhao; Lu, Daru; Yan, Tengyu; He, Junyu

doi:10.1016/j.pestbp.2023.105581

Cited by 16 publications

(5 citation statements)

References 42 publications

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“…46 Fungicidal agents can disrupt cell membrane structure to limit fungal growth and proliferation. 47 These results indicated that compound 4o disrupted the cell membranes by increasing the cell membrane permeability, gradually leading to the death of R. solani.…”

Section: ■ Results and Discussionmentioning

confidence: 92%

“…The cell membrane is an important cellular structure of fungi, which is essential to maintaining normal morphology and biological functions . Fungicidal agents can disrupt cell membrane structure to limit fungal growth and proliferation . These results indicated that compound 4o disrupted the cell membranes by increasing the cell membrane permeability, gradually leading to the death of R.…”

Section: Resultsmentioning

confidence: 99%

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Antifungal Activity and Mechanism of Camphor Derivatives against Rhizoctonia solani: A Promising Alternative Antifungal Agent for Rice Sheath Blight

Zhang,

Huang,

Duan

et al. 2024

J. Agric. Food Chem.

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Rice sheath blight, caused by the fungus Rhizoctonia solani, poses a significant threat to rice cultivation globally. This study aimed to investigate the potential mechanisms of action of camphor derivatives against R. solani. Compound 4o exhibited superior fungicidal activities in vitro (EC 50 = 6.16 mg/L), and in vivo curative effects (77.5%) at 500 mg/L were significantly (P < 0.01) higher than the positive control validamycin•bacillus (66.1%). Additionally, compound 4o exhibited low cytotoxicity and acute oral toxicity for adult worker honeybees of Apis mellifera L. Mechanistically, compound 4o disrupted mycelial morphology and microstructure, increased cell membrane permeability, and inhibited both PDH and SDH enzyme activities. Molecular docking and molecular dynamics analyses indicated a tight interaction of compound 4o with PDH and SDH active sites. In summary, compound 4o exhibited substantial antifungal efficacy against R. solani, serving as a promising lead compound for further optimization of antifungal agents.

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Section: ■ Results and Discussionmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Antifungal Activity and Mechanism of Camphor Derivatives against Rhizoctonia solani: A Promising Alternative Antifungal Agent for Rice Sheath Blight

Zhang,

Huang,

Duan

et al. 2024

J. Agric. Food Chem.

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“…The antifungal activity test of compound W3 was performed by the method of our previous work . The antifungal activity of compound W3 at a concentration of 20 mg/L against Sclerotinia sclerotiorum (S.…”

Section: Methodsmentioning

confidence: 99%

“…The antifungal activity test of compound W3 was performed by the method of our previous work. 33 The antifungal activity of compound W3 at a concentration of 20 mg/L against Sclerotinia sclerotiorum (S. sclerotiorum), Fusarium graminearum (F. graminearum), Magnaporthe oryzae (M. oryzae), Rhizoctonia solani (R. solani), and Phomopsis sp. was tested, and fluopyram (purity: 96.5%) was regarded as a positive control.…”

Section: = + ×mentioning

confidence: 99%

Discovery and Mechanism of a Nematicide Candidate (W3): A Novel Amide Compound Containing a Cyclopropyl Moiety

Wang,

Zhang,

Wang

et al. 2024

J. Agric. Food Chem.

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To find novel nematicides, we screened the nematicidal activity of compounds in our laboratory compound library. Interestingly, the compound N-((1R,2R)-2-(2-fluoro-4-(trifluoromethyl)phenyl)cyclopropyl)-2-(trifluoromethyl)benzamide (W3) showed a broad spectrum and excellent nematicidal activity. The LC50 values of compound W3 against second-stage juveniles of Bursaphelenchus xylophilus (B. xylophilus), Aphelenchoides besseyi, and Ditylenchus destructor are 1.30, 1.63, and 0.72 mg/L, respectively. Nematicidal activities of compound W3 against second-stage juveniles of Meloidogyne incognita were 87.66% at 100 mg/L. Meanwhile, compound W3 can not only observably inhibit the feeding, reproduction, and egg hatching of B. xylophilus but can also effectively promote the oxidative stress adverse reactions of nematodes and cause intestinal damage. Compound W3 can promote the production of MDA and inhibit the activities of defense enzymes SOD and GST in B. xylophilus. Compound W3 can affect the transcription of genes involved in regulating the tricarboxylic acid cycle in nematodes, resulting in weakened nematode respiration and reduced nematode activity and even death. In addition, compound W3 had good inhibitory activity against five pathogenic fungi. Among them, the EC50 of compound W3 against Fusarium graminearum was 8.4 mg/L. In the future, we will devote ourselves to the toxicological and structural optimization research of the candidate nematicide W3.

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“…Soluble protein content was determined at 595 nm and soluble sugar content was determined at 620 nm and expressed as mg/ g. The experiment was repeated three times. [36]…”

Section: Cellular Leakagementioning

confidence: 99%

Industrial Distillation Fractions of Garlic Essential Oil, Design, Synthesis, and Antifungal Activity Evaluation of Aliphatic Substituted Trisulfide Derivatives

Chen,

Wang,

Wang

et al. 2024

Chemistry & Biodiversity

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Garlic oil has a wide range of biological activities, and its broad‐spectrum activity against phytopathogenic fungi still has the potential to be explored. In this study, enzymatic treatment of garlic resulted in an increase of approximately 50 % in the yield of essential oil, a feasible GC‐MS analytical program for garlic oil was provided. Vacuum fractionation of the volatile oil and determination of its inhibitory activity against 10 fungi demonstrated that garlic oil has good antifungal activity. The antifungal activity levels were ranked as diallyl trisulfide (S‐3)>diallyl disulfide (S‐2)>diallyl monosulfide (S‐1), with an EC50 value of S‐3 against Botrytis cinerea reached 8.16 mg/L. Following the structural modification of compound S‐3, a series of derivatives, including compounds S‐4~7, were synthesized and screened for their antifungal activity. The findings unequivocally demonstrated that the compound dimethyl trisulfide (S‐4) exhibited exceptional antifungal activity. The EC50 of S‐4 against Sclerotinia sclerotiorum reached 6.83 mg/L. SEM, In vivo experiments, and changes in mycelial nucleic acids, soluble proteins and soluble sugar leakage further confirmed its antifungal activity. The study indicated that the trisulfide bond structure was the key to good antifungal activity, which can be developed into a new type of green plant‐derived fungicide for plant protection.

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Putrescine (1,4-Diaminobutane) enhances antifungal activity in postharvest mango fruit against Colletotrichum gloeosporioides through direct fungicidal and induced resistance mechanisms

Cited by 16 publications

References 42 publications

Antifungal Activity and Mechanism of Camphor Derivatives against Rhizoctonia solani: A Promising Alternative Antifungal Agent for Rice Sheath Blight

Antifungal Activity and Mechanism of Camphor Derivatives against Rhizoctonia solani: A Promising Alternative Antifungal Agent for Rice Sheath Blight

Discovery and Mechanism of a Nematicide Candidate (W3): A Novel Amide Compound Containing a Cyclopropyl Moiety

Industrial Distillation Fractions of Garlic Essential Oil, Design, Synthesis, and Antifungal Activity Evaluation of Aliphatic Substituted Trisulfide Derivatives

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