Putting Peritoneal Dialysis Catheter Infections Into Perspective

Piraino, Beth

doi:10.1053/j.ajkd.2019.07.004

Cited by 1 publication

(1 citation statement)

References 9 publications

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“…Silicone rubber, one of the most common biomaterials, is widely used in biomedical implants, such as silicone peritoneal catheters [5], urinary catheters [6], and silicone airway stents [7], because of its great biocompatibility and stable mechanical properties. Unfortunately, silicone rubber is susceptible to bacterial adhesion and biofilm formation, which can lead to ineffectiveness of conventional antibiotic therapies against biofilms [8,9].…”

Section: Introductionmentioning

confidence: 99%

A printing-spray-transfer process for attaching biocompatible and antibacterial coatings to the surfaces of patient-specific silicone stents

Liu¹,

Yao²,

Ye³

et al. 2020

Biomed. Mater.

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An antibacterial coating with stable antibacterial properties and favorable biocompatibility is recognized as an effective method to prevent bacterial adhesion and biofilm formation on biomedical implant surfaces. In this study, a convenient and low-cost printing-spray-transfer process was proposed that enables reliably attaching antibacterial and biocompatible coatings to patient-specific silicone implant surfaces. A desktop three-dimensional printer was used to print the mold of silicone implant molds according to the characteristics of the diseased areas. Multiwalled carbon nanotubes (MWCNTs) uniformly decorated with silver nanoparticles (AgNPs/CNTs) were synthesized as the antibacterial materials for the spray process. The well-distributed AgNPs/CNT coating was anchored to the silicone surface through an in-mold transfer printing process. Stable adhesion of the coatings was assessed via tape testing and UV–vis spectra. Hardly any AgNPs/CNTs peeled off the substrate, and the adhesion was rated at 4B. Antibacterial activity, Ag release, cell viability and morphology were further assessed, revealing high antibacterial activity and great biocompatibility. The process proposed herein has potential applications for fabricating stable antibacterial coatings on silicone implant surfaces, especially for patient-specific silicone implants such as silicone tracheal stents.

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