Putting surface-enhanced Raman spectroscopy to work for nanozyme research: Methods, materials and applications

Mu, Ming; Wen, Sisi; Hu, Saizhen; Zhao, Bing; Song, Wei

doi:10.1016/j.trac.2022.116603

Cited by 27 publications

(8 citation statements)

References 120 publications

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“…In the field of bioanalysis and detection, surface-enhanced Raman spectroscopy (SERS)-based biosensors have recently attracted a lot of interest due to their high sensitivity, efficiency, accuracy, low sample demand, and non-destructive nature [ 126 , 127 ]. Raman spectroscopy receives its signal from Raman scattering produced by a Raman reporter on the surface of plasmonic nanomaterials like gold, silver, silicon, porous alumina, or their combinations [ 128 ]. The SERS signal can be modified through the reaction of reporter molecules by incorporating peroxidase nanozymes with the plasmonic nanostructures [ 129 ].…”

Section: Nanozyme-based Biosensorsmentioning

confidence: 99%

Nanozymes towards Personalized Diagnostics: A Recent Progress in Biosensing

Kurup

Ahmed

2023

Biosensors

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This review highlights the recent advancements in the field of nanozymes and their applications in the development of point-of-care biosensors. The use of nanozymes as enzyme-mimicking components in biosensing systems has led to improved performance and miniaturization of these sensors. The unique properties of nanozymes, such as high stability, robustness, and surface tunability, make them an attractive alternative to traditional enzymes in biosensing applications. Researchers have explored a wide range of nanomaterials, including metals, metal oxides, and metal–organic frameworks, for the development of nanozyme-based biosensors. Different sensing strategies, such as colorimetric, fluorescent, electrochemical and SERS, have been implemented using nanozymes as signal-producing components. Despite the numerous advantages, there are also challenges associated with nanozyme-based biosensors, including stability and specificity, which need to be addressed for their wider applications. The future of nanozyme-based biosensors looks promising, with the potential to bring a paradigm shift in biomolecular sensing. The development of highly specific, multi-enzyme mimicking nanozymes could lead to the creation of highly sensitive and low-biofouling biosensors. Integration of nanozymes into point-of-care diagnostics promises to revolutionize healthcare by improving patient outcomes and reducing costs while enhancing the accuracy and sensitivity of diagnostic tools.

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Section: Nanozyme-based Biosensorsmentioning

confidence: 99%

Nanozymes towards Personalized Diagnostics: A Recent Progress in Biosensing

Kurup

Ahmed

2023

Biosensors

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“…The Mie‐resonance scattered near‐field effect occurring on submicron semiconductor materials can generate EM, which synergistically contributes to the enhancement of SERS along with the CT effect. [ 222 ] The introduction of nanozymes into SERS sensing systems mainly involves either NP materials with enzymatic catalytic activity or complexes of SERS‐active materials and nanozymes. Nanozymes serve two primary roles in SERS sensing: SERS active material‐nanozyme complexes typically function as substrates and signal providers for SERS reactions, while nanozymes with only enzymatic activity are usually added as catalysts after the addition of SERS substrates to the reaction.…”

Section: Nanozymes Enhance Sers Sensing Sensitivity By Boosting “Hot ...mentioning

confidence: 99%

Signal Amplification Strategy Design in Nanozyme‐Based Biosensors for Highly Sensitive Detection of Trace Biomarkers

Wang,

Liu,

Fan

2023

Small Methods

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Nanozymes show great promise in enhancing disease biomarker sensing by leveraging their physicochemical properties and enzymatic activities. These qualities facilitate signal amplification and matrix effects reduction, thus boosting biomarker sensing performance. In this review, recent studies from the last five years, concentrating on disease biomarker detection improvement through nanozyme‐based biosensing are examined. This enhancement primarily involves the modulations of the size, morphology, doping, modification, electromagnetic mechanisms, electron conduction efficiency, and surface plasmon resonance effects of nanozymes for increased sensitivity. In addition, a comprehensive description of the synthesis and tuning strategies employed for nanozymes has been provided. This includes a detailed elucidation of their catalytic mechanisms in alignment with the fundamental principles of enhanced sensing technology, accompanied by the presentation of quantitatively analyzed results. Moreover, the diverse applications of nanozymes in strip sensing, colorimetric sensing, electrochemical sensing, and surface‐enhanced Raman scattering have been outlined. Additionally, the limitations, challenges, and corresponding recommendations concerning the application of nanozymes in biosensing have been summarized. Furthermore, insights have been offered into the future development and outlook of nanozymes for biosensing. This review aims to serve not only as a reference for enhancing the sensitivity of nanozyme‐based biosensors but also as a catalyst for exploring nanozyme properties and their broader applications in biosensing.

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“…Surface-enhanced Raman scattering (SERS) is a highly sensitive molecular spectroscopic technique that provides structural insights into substances. Transition metal sulfides (TMS), with high electron mobility, capability for charge transfer, and narrow band gaps, contribute to charge transfer (CT) enhancement and electromagnetic field (EM) amplification in the SERS mechanism. − Consequently, TMS-based SERS active materials are employed across a range of domains including biosensing, disease treatment, environmental monitoring, catalytic kinetics analysis, and immunoassays.…”

Section: Introductionmentioning

confidence: 99%

Research on Surface-Enhanced Raman Spectroscopy and Simulated Laccase Activity of Two-Dimensional Metal Sulfide Nanosheets

Wen,

Jiang,

Yang

et al. 2024

J. Phys. Chem. C

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Transition metal sulfides (TMS) exhibit unique attributes such as high electron mobility, excellent charge transfer ability, narrow band gap, and large surface area, which makes them particularly attractive for use in surface-enhanced Raman spectroscopy (SERS) and as catalysts applications. In this study, we prepared NiCo 2 S 4 TMS nanosheets through a hydrothermal process. These nanosheets display outstanding SERS activity, which is attributed to their exceptional charge transfer interactions with crystal violet (CV). In addition, NiCo 2 S 4 nanosheets display excellent laccase-like activity. Density functional theory (DFT) calculations further reveal that NiCo 2 S 4 −O 2 exhibits a low adsorption energy and pronounced laccase-like catalytic performance. Furthermore, the NiCo 2 S 4 nanosheets show great potential for the oxidation and detection of various catechin molecules. Consequently, the NiCo 2 S 4 nanosheets exhibit immense potential in various applications, including SERS analysis and detection, laccase-like antibacterial properties, and the degradation of environmental pollutants.

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Putting surface-enhanced Raman spectroscopy to work for nanozyme research: Methods, materials and applications

Cited by 27 publications

References 120 publications

Nanozymes towards Personalized Diagnostics: A Recent Progress in Biosensing

Nanozymes towards Personalized Diagnostics: A Recent Progress in Biosensing

Signal Amplification Strategy Design in Nanozyme‐Based Biosensors for Highly Sensitive Detection of Trace Biomarkers

Research on Surface-Enhanced Raman Spectroscopy and Simulated Laccase Activity of Two-Dimensional Metal Sulfide Nanosheets

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