Puva

Psoralen: a narrative review of current and future therapeutic uses

“…Cells with aberrant or high rates of cellular division are more selectively targeted by photoactivated psoralen, resulting in the initiation of apoptosis in cells at the core of many diverse pathologies, such as cancers and autoimmune conditions. The long-lasting immunogenic effects of psoralen are attributed to the acute photoadduct DNA damage it causes (Lim et al 2005 ; Bethea et al 1999 ). This DNA damage, triggered by photoactivated psoralen, leads to the generation of apoptotic cells.…”

“…Psoralen is a naturally occurring phytoalexin found in the seeds of Psoralea corylifolia plants and certain fruits, such as figs and citrus fruits, whose chemical structure resembles that of coumarin due to the addition of a fused furan ring (Ruan et al 2007 ). Psoralen’s clinical use dates back to 2000 BC in ancient Egypt and India, where it was utilized in the treatment of various skin conditions due to its photosensitive properties (Lim et al 2005 ). In those early applications, preparations containing psoralen were either ingested or applied topically to the skin.…”

“…In those early applications, preparations containing psoralen were either ingested or applied topically to the skin. Subsequently, individuals would expose themselves to sunlight to activate the therapeutic compounds (Lim et al 2005 ; Perrine et al 2007 ). Psoralen has been available in the United States since the mid-twentieth century, with first reports indicating the use of ultraviolet A (UVA) light for photoactivation (Lim et al 2005 ; Perrine et al 2007 ; Bethea et al 1999 ).…”

“…Subsequently, individuals would expose themselves to sunlight to activate the therapeutic compounds (Lim et al 2005 ; Perrine et al 2007 ). Psoralen has been available in the United States since the mid-twentieth century, with first reports indicating the use of ultraviolet A (UVA) light for photoactivation (Lim et al 2005 ; Perrine et al 2007 ; Bethea et al 1999 ). This review will explore the mechanism of activity, established clinical utility, current investigation, and potential future uses of photoactivated psoralens.…”