PVA-based bulk microneedles capable of high insulin loading and pH-triggered degradation for multi-responsive and sustained hypoglycemic therapy

Ma, Yuhong; Wang, Wei; He, Mujiao; Liu, Yunzhu; Li, Caihua; Zhong, Yinan; Bu, Quanmin; Huang, Dechun; Qian, Hongliang; Chen, Wei

doi:10.1039/d3bm01760e

Cited by 6 publications

(1 citation statement)

References 44 publications

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“…In our previous studies, UV cross-linking reactions were commonly used to enhance the stability of the carrier structure and mitigate premature drug release. 30,31 Therefore, it is interesting to integrate the glucose-responsive structure with UV crosslinking to safeguard insulin from external proteases, prevent untimely drug release, and achieve desirable glucose responsiveness together with prolonged glucose-lowering duration.…”

Section: Introductionmentioning

confidence: 99%

Dually crosslinked degradable polyionic micelles for sustained glucose-responsive insulin release

Ma,

Xing,

Han

et al. 2024

Biomater. Sci.

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Section: Introductionmentioning

confidence: 99%

Dually crosslinked degradable polyionic micelles for sustained glucose-responsive insulin release

Ma,

Xing,

Han

et al. 2024

Biomater. Sci.

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Glucose Oxidase‐Immobilized Dually‐Crosslinked Nanogels for Rapid‐Responsive Insulin Delivery

Ma,

Yang,

et al. 2024

Adv Healthcare Materials

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Despite the potential benefits of close‐looped insulin delivery systems in regulating glycemic homeostasis and effectively alleviating diabetes, they still encounter challenges such as limited effectiveness in preventing low glycemic episodes due to sluggish glucose response, and issues with the instability of enzymes and carriers. In this study, dually‐crosslinked and glucose oxidase (GOx)‐immobilized insulin nanogels (DC‐NGs@Ins) are developed for rapid‐responsive and sustained hypoglycemic therapy. The DC‐NGs@Ins with the phenylborate ester linker enabled the insulin release in a close‐looped fashion, and moreover, immobilized GOx‐generated hydrogen peroxide (H2O2) by consuming the glucose, which can further bind to phenylborate ester for enhancing glucose response and accelerating the insulin release. The dually‐crosslinked structure (phenylboronic ester and UV‐crosslinking) effectively minimized the initial burst release of insulin, thus preventing the potential risk of hypoglycemia. More interestingly, GOx immobilized in the nanogels mitigated GOx leakage and enhanced its multiple utilization compared to free GOx. In vivo study demonstrated that DC‐NGs@Ins effectively maintained glycemic levels (BGLs) below 200 mg dL−1 for at least 8 h compared to singly‐crosslinked nanogels (SC‐NGs@Ins). Therefore, this intelligent insulin delivery system shows potential applications in diabetes treatment.

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Long‐Lasting Simultaneous Epidermal and Dermal Microneedle‐Enabled Drug Delivery

Sarabi,

Farshi,

Saltik

et al. 2024

Adv Materials Technologies

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Different skin diseases, such as cancers, inflammatory conditions, and bacterial infections, manifest at distinct skin depths. Microneedle arrays, recognized for their painless and minimally invasive drug administration, can be customized to penetrate these layers simultaneously. Here, the design of the microneedles (MNs) in nonlinear ways with diverse needle heights on the array enabling concurrent drug delivery to various skin layers is engineered. Additionally, varying the base diameter of the needles in the array facilitates prolonged or intermittent drug release, depending on the biodegradation kinetics of these needles. MNs, microfabricated with a biocompatible and biodegradable polymer, are validated by skin administration. The nonlinear design of the MNs on the array introduces a novel perspective on addressing skin diseases at varying depths of the skin.

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PVA-based bulk microneedles capable of high insulin loading and pH-triggered degradation for multi-responsive and sustained hypoglycemic therapy

Abstract: “Closed-loop” insulin-loaded microneedle patches show great promise for improving therapeutic outcomes and life quality for diabetes patients.

Cited by 6 publications

References 44 publications

Dually crosslinked degradable polyionic micelles for sustained glucose-responsive insulin release

Dually crosslinked degradable polyionic micelles for sustained glucose-responsive insulin release

Glucose Oxidase‐Immobilized Dually‐Crosslinked Nanogels for Rapid‐Responsive Insulin Delivery

Long‐Lasting Simultaneous Epidermal and Dermal Microneedle‐Enabled Drug Delivery

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