PVC Supported Liquid Membrane and Carbon Paste Potentiometric Sensors Incorporating a Mn(III)‐Porphyrin for the Direct Determination of Undissociated Paracetamol

Saraswathyamma, Beena; Pajak, Marta; Radecki, Jerzy; Maes, Wouter; Dehaen, Wim; Kumar, Krishnapillai Girish; Radecka, Hanna

doi:10.1002/elan.200804280

Cited by 15 publications

(13 citation statements)

References 42 publications

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“…Electrodes formulated with plasticized poly(vinyl chloride) (PVC) membranes containing tetraphenylborate salts of barium complexes with given polyethoxylates5a–c or hydrogen‐ion carriers5d show cationic responses to acyclic polyether‐based nonionic surfactants, which are attributed to the partitioning of the surfactant/metal cation complexes coextracted into the membranes. Anionic responses are induced by undissociated neutral phenols using PVC matrix liquid membranes containing lipophilic nitrogen‐containing compounds6a–b or metal porphyrins6c as sensory elements. The net movement of protons from the membrane interface to the aqueous phase stimulated by uncharged phenols is responsible for the anionic response.…”

Section: Methodsmentioning

confidence: 99%

Potentiometric Sensing of Neutral Species Based on a Uniform‐Sized Molecularly Imprinted Polymer as a Receptor

et al. 2010

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Polymeric membrane ion-selective electrodes (ISEs) have been routinely used for determination of ionic species in clinical applications and for the determination of water quality owing to their attractive features including excellent selectivity, low cost, ease of use, and high reliability. [1][2][3] This well-established analytical technology has undergone a quiet revolution over the last few years. The detection limits of ISEs have been lowered from the micromolar to the subnanomolar range, and the discrimination of interfering ions has been improved by many orders of magnitude.[4] Currently, the application of ISEs has evolved to provide a promising measurement technique for environmental trace analysis and potentiometric biosensing. However, it has remained an open challenge for analytical chemists to develop potentiometric sensors for uncharged molecules, since the prerequisite for the general mechanism of potentiometric response is the occurrence of a charge on an analyte. Very few ISEs have been reported for which the membrane potentials are affected by neutral molecules. Electrodes formulated with plasticized poly(vinyl chloride) (PVC) membranes containing tetraphenylborate salts of barium complexes with given polyethoxylates [5a-c] or hydrogen-ion carriers [5d] show cationic responses to acyclic polyether-based nonionic surfactants, which are attributed to the partitioning of the surfactant/ metal cation complexes coextracted into the membranes. Anionic responses are induced by undissociated neutral phenols using PVC matrix liquid membranes containing lipophilic nitrogen-containing compounds [6a-b] or metal porphyrins [6c] as sensory elements. The net movement of protons from the membrane interface to the aqueous phase stimulated by uncharged phenols is responsible for the anionic response. Although these approaches have made great contributions toward the potentiometric detection of neutral species, the sensors developed show rather poor selectivities because the potential response is governed mainly by the lipophilicity of the neutral molecules, rather than specific molecular recognition. So far, a potentiometric sensor with a synthetic carrier that selectively binds neutral species is still apparently unknown. [2b] As highly suitable receptors, molecularly imprinted polymers (MIPs) have emerged as attractive, simple, and seemingly general materials for the selective binding of a wide range of analytes with affinities and selectivities similar to those of antibodies, enzyme, and hormone receptors. [7][8][9][10] Compared to their biological counterparts, MIPs are more stable, less costly, and easier to produce. Such materials are synthesized in the presence of functional monomers, template molecules, and a cross-linking agent by covalent, [11] noncovalent, [12] and sacrificial spacer methods. [13] Binding sites with molecular recognition properties are formed after template molecules have been removed from the polymerized material, leaving behind cavities for the subsequent rebinding process tha...

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Section: Methodsmentioning

confidence: 99%

Potentiometric Sensing of Neutral Species Based on a Uniform‐Sized Molecularly Imprinted Polymer as a Receptor

et al. 2010

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“…However, very few ISEs have been developed for direct recognition of neutral species [2]. In recent years, it has been found that undissociated neutral phenols could generate anionic potential responses using poly(vinyl chloride) (PVC) liquid membranes doped with lipophilic nitrogen-containing compounds and metal porphyrins [3][4][5]. The net movement of hydrogen ions from the membrane interface to the aqueous phase stimulated by uncharged phenols is responsible for the anionic responses (Eq.…”

Section: Introductionmentioning

confidence: 99%

Potentiometric sensor for determination of neutral bisphenol A using a molecularly imprinted polymer as a receptor

et al. 2013

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The aim of this paper is to develop a potentiometric sensing methodology for sensitive and selective determination of neutral phenols by using a molecularly imprinted polymer as a receptor. Bisphenol A (BPA), a significant environmental contaminant, is employed as the model target. The BPA-imprinted polymer is synthesized by the semi-covalent technique and incorporated into a plasticized poly(vinyl chloride) membrane doped with the tridodecylmethylammonium salt. The present electrode shows a linear anionic potential response over the concentration range from 0.1 to 1 μM with a detection limit of 0.02 μM, and exhibits an excellent selectivity over other phenols. The proposed approach has been successfully applied to the determination of BPA released from real plastic samples. It offers promising potential in development of potentiometric sensors for measuring neutral phenols at trace levels.

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“…In continuation of our work on drug analysis,24–28 an attempt has been made to develop a convenient method for the determination of the drug, Trimethoprim (TMP). This work details an electrochemical method for the determination of TMP using [5,10,15,20‐tetrakis(4‐methoxyphenyl)porphyrinato]Mn(III)chloride film modified glassy carbon electrode (TMOPPMn(III)Cl/GCE).…”

Section: Introductionmentioning

confidence: 99%

Electroanalysis of trimethoprim on metalloporphyrin incorporated glassy carbon electrode

Rajith

Kumar

2010

Drug Testing and Analysis

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Trimethoprim (TMP) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections. It belongs to the class of chemotherapeutic agents known as dihydrofolate reductase inhibitors. Its use is associated with idiosyncratic reactions, including liver toxicity and agranulocytosis. In order to determine TMP electrochemically, a metalloporphyrin modified glassy carbon electrode was prepared by coating [5,10,15,20- tetrakis(4-methoxyphenyl) porphyrinato]Mn (III)chloride (TMOPPMn(III)Cl) solution on the surface of the electrode. The electrochemical behaviour of TMP in Phosphate buffer solution (PBS) on TMOPPMn(III)Cl modified glassy carbon electrode (TMOPPMn(III)Cl/GCE) was explored using differential pulse voltammetry (DPV). The voltammograms showed enhanced oxidation response at the TMOPPMn (III)Cl/GCE with respect to the bare GCE for TMP, attributable to the electrocatalytic activity of TMOPPMn(III)Cl. Electrochemical parameters of the oxidation of TMP on the modified electrode were analyzed. The electro-oxidation of TMP was found to be irreversible, pH dependent and adsorption controlled on the modified electrode. It is found that the oxidation peak current is proportional to the concentration of TMP over the range 6 × 10⁻⁸ - 1 × 10⁻⁶ M with a very low detection limit of 3 × 10⁻⁹ M at 2 min open circuit accumulation. The repeatability expressed as relative standard deviation (RSD) for n = 9 was 3.2% and the operational stability was found to be 20 days. Another striking feature is that equimolar concentration of sulfamethoxazole did not interfere in the determination of TMP. Applicability to assay the drug in urine and tablet samples has also been studied.

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PVC Supported Liquid Membrane and Carbon Paste Potentiometric Sensors Incorporating a Mn(III)‐Porphyrin for the Direct Determination of Undissociated Paracetamol

Cited by 15 publications

References 42 publications

Potentiometric Sensing of Neutral Species Based on a Uniform‐Sized Molecularly Imprinted Polymer as a Receptor

Potentiometric Sensing of Neutral Species Based on a Uniform‐Sized Molecularly Imprinted Polymer as a Receptor

Potentiometric sensor for determination of neutral bisphenol A using a molecularly imprinted polymer as a receptor

Electroanalysis of trimethoprim on metalloporphyrin incorporated glassy carbon electrode

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