PVP-coated Sb₂Se₃ nanorods as nanotheranostic agents for photoacoustic imaging and photothermal therapy in NIR-I bio-windows

Abstract

Herein we reported a biocompatible PVP-coated Sb2Se3 nanorods as PTT nanotheranostic agent, which is responsive to the light (808 and 980 nm) in NIR-I bio-windows and effective for photoacoustic imaging and photothermal destruction of cancer cell.

Pnictogen Semimetal (Sb, Bi)-Based Nanomaterials for Cancer Imaging and Therapy: A Materials Perspective

“…The η value of the yielded 2D PVP-capped Sb 2 Se 3 NSs in this work was determined to be 40.56% at 808 nm, and the photothermal conversion performance remained stable after five cycles, which further depicted good performance for PAI and tumor thermal ablation. The biomedical potentials of nanostructured Sb 2 Se 3 were also reported in Sb 2 Se 3 nanorods (NRs) by Qu et al They prepared PVP-coated 500 nm long Sb 2 Se 3 NRs by the conventional solvent hydrothermal method. A broad UV–vis–NIR absorption was observed with a higher intensity in the NIR window.…”

NIR-Excitable PEG-Modified Au Nanorods for Photothermal Therapy of Cervical Cancer

“…To further enhance the therapeutic efficacy and exert fewer side effects, photothermal therapy (PTT) is becoming a promising approach to overcome these drawbacks. , Based on the photoinduced heating of a photothermal agent, PTT under specific laser radiation could effectively ablate cancer cells without affecting normal tissues. − However, the penetration depth of emission or/and excitation light is severely influenced by the photon absorption and scattering in biological samples . Compared to the wavelengths in the spectral window (390–700 nm), the light in the near-infrared (NIR, 700–1700 nm) wavelength region can penetrate into the deeper tissue with less scattering. − Therefore, it is urgent to design nanomaterials that can effectively absorb NIR light in the field of biomedical therapy, and photothermal agents have been developed for the ablation of tumors. − …”