PWE-023 Is It Worth Chasing Incidental Colonic Hot Spots On Routine Pet Ct Scans?

Ngu, WS; Sinha, Rohit; Aitken, Dawn; Ramadas, Arvind; Reddy, A; Jha, Madan K.

doi:10.1136/gutjnl-2014-307263.283

Cited by 1 publication

(4 citation statements)

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“…2 Cancer detection rates of 7.8-18.9% have been quoted in various studies. 1,3 Our aim was to evaluate colonic FDG avid lesions on PET by endoscopy. Methods An analysis of prospectively collected database of all patients (n = 1564) who had PET for various malignancy between January 2011 to September 2013 was performed.…”

Section: Referencesmentioning

confidence: 99%

“…Median age was 64 with a male preponderance (2.5:1) Location on PET CT was categorised to sigmoid (23), rectal (9), anorectal (4), caecal (3), hepatic flexure (2), transverse (1), splenic flexure (1), ascending (1) and descending (1).…”

Section: Referencesmentioning

confidence: 99%

“…Findings on endoscopy ranged from polyps (22), normal (9), diverticulosis (8), sigmoid cancer (4), caecal cancer (1) and colitis (1).…”

Section: Referencesmentioning

confidence: 99%

“…When suspected, guidelines advise colonoscopy with full biopsy series due to reports of a patchy disease distribution, with false negative rates of up to 40% reported with flexible sigmoidoscopy. 1 However, more recent data has challenged this assumption, leaving considerable uncertainty. 2 We report one of the largest consecutive case series to date, examining whether flexible sigmoidoscopy alone is sufficient.…”

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confidence: 99%

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PWE-021 Mtorc1 Mediated Translational Elongation Is Limiting For Intestinal Tumour Initiation And Growth

Faller

Jackson

et al. 2014

Gut

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Methods The operation and technical performance of each system was assessed and compared with manufacturers' claims using the manufacturers' recommended sample collection tube loaded with haemoglobin (Hb)-spiked faecal samples or Hb in buffer. Results All collection tubes and analysers were considered useable, although the BioMajesty was unnecessarily complex for a single analyte. The use of re-usable cuvettes by NS-PLUS, OC--SENSOR DIANA and BioMajesty increases the volume of water waste, but reduces plastic clinical waste. HM-JACKarc and NS--PLUS were the most analytically sensitive (accurately measures to the lowest concentration). Imprecision with NS-PLUS was inconsistent with manufacturers' claims; imprecision for OC-SENSOR DIANA and BioMajesty could not be compared directly with manufacturers' claims due to differences between mean concentrations of the samples. All analysers except BioMajesty demonstrated good linearity. Precision (variation of measurement) was good for HM-JACKarc and for OC-SENSOR DIANA within the manufacturers' recommended range. Automated or semi-automated dilution of highly concentrated samples was available with all analysers, except HM-JACKarc, which has a limited measurement range. The NS-PLUS and BioMajesty did not alert the user to a hook/prozone effect (erroneously low values at exceptionally high concentrations). Sample stability over a range of temperatures was similar to manufacturers' claims for all analysers and much improved from previous studies. Whilst fewer staff may be required for screening, they will need further laboratory training to process FIT samples. Conclusion This evaluation provides essential information to guide the BCSP through the usual tendering procedure. Introduction Microscopic colitis is a common cause of chronic diarrhoea, particularly in older people, and the incidence is increasing. As the endoscopic appearance is typically normal, diagnosis of the two subtypes, collagenous and lymphocytic colitis, relies upon specific histology findings. When suspected, guidelines advise colonoscopy with full biopsy series due to reports of a patchy disease distribution, with false negative rates of up to 40% reported with flexible sigmoidoscopy.1 However, more recent data has challenged this assumption, leaving considerable uncertainty. 2 We report one of the largest consecutive case series to date, examining whether flexible sigmoidoscopy alone is sufficient. Methods A retrospective review of all cases of microscopic colitis diagnosed at colonoscopy over a 12-year period (2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013) at our hospital was performed. Only colonoscopies with both right (proximal to splenic flexure) and left sided colonic biopsies were included. The diagnostic criteria for microscopic colitis were lymphocytic infiltration in the lamina propria and either >20 intraepithelial lymphocytes per 100 epithelial cells (lymphocytic colitis) or a collagenous layer >10 mm (collagenous colitis). The primary aim was to assess the...

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Section: Referencesmentioning

confidence: 99%

Section: Referencesmentioning

confidence: 99%

“…Findings on endoscopy ranged from polyps (22), normal (9), diverticulosis (8), sigmoid cancer (4), caecal cancer (1) and colitis (1).…”

Section: Referencesmentioning

confidence: 99%

mentioning

confidence: 99%

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