PWE-126 Spontaneous Bacterial Peritonitis (sbp) Is Rare Among Routine Elective Day-case Therapeutic Paracentesis: Is Routine Fluid Analysis Justified?

Abstract

NASH and 7% Hepatitis C. Median MELD score was 15.5 (IQR 13.5-21). All patients were prescribed lactulose. Of the 30 patients, 5 died within 6 months of commencing Rifaximin. One patient was discontinued, due to non-compliance. 24 patients were included in the final analysis. We compared the outcomes for the 6 months prior to, and the 6 months after commencing Rifaximin treatment. Median hospital admissions were reduced from 2 admissions (IQR 1-3, Range 1-5) to 1 admission (IQR 0-2, Range 0-4, Wilcoxon p < 0.05). Median number of bed days was reduced from 27.5 (IQR 16.0-35.3, Range 2-129) to 2.5 (IQR 0-23.5, Range 0-55, Wilcoxon p < 0.05). No patient developed Clostridium difficile-associated diarrhoea in the 6 months after commencing Rifaximin. Conclusion In our hospital, the basic cost of a hospital bed day is £300. A 6 month course of Rifaximin costs £1688. This study demonstrates that Rifaximin treatment in patients with HE, due to chronic liver disease, produced a marked reduction in hospital admissions and hospital bed day occupancy in a District General Hospital, with major cost savings and improved clinical outcomes. Disclosure of Interest None Declared.

Incidence of spontaneous bacterial peritonitis among asymptomatic cirrhosis patients undergoing outpatient paracentesis: a systematic review and meta-analysis

“…A total of 499 studies were identified through electronic database searches and an additional five records through supplementary sources from reviewing citing papers and reference lists of selected relevant studies; 419 titles and abstracts were screened after duplicate articles were removed; 38 full-text articles and conference abstracts were reviewed for eligibility and 16 were included [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. Two articles [31,32] had similar results and data; the author and journal were contacted but did not respond.…”