2024
DOI: 10.1111/andr.13774
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PWWP3A deficiency accelerates testicular senescence in aged mice

Zhen Chen,
Cong Liu,
Wei Qu
et al.

Abstract: BackgroundThe PWWP domain‐containing proteins are involved in chromatin‐associated biological processes, including transcriptional regulation and DNA repair, and most of them are significant for gametogenesis and early embryonic development in mammals. PWWP3A, one of the PWWP domain proteins, is a reader of H3K36me2/H3K36me3 and a response factor to DNA damage. However, the physiological role of PWWP3A in spermatogenesis and fertility remains unclear.ObjectiveThe goal of this study was to explore the function … Show more

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