Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice

Liu, F. J.; Zhang, Y. X.; Lau, Benjamin H.S.

doi:10.1007/s000180050245

Cited by 42 publications

(19 citation statements)

References 19 publications

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“…E1, E2 and E3 respectively represent extracts of seed, skin and berry stem of Pusa Navarang grape cultivar and E4, E5, E6 respectively represent extracts of seed, skin and berry stem of Merlot grape cultivar. Different letters (a, b, c) on top of bar (mean±SD) indicates significance difference (p≤0.05), between different parts seed, skin and berry stem and letters x and y indicates significance difference between without extract and with extract respectively compounds are attributed to the flavan-3-ols and other polymeric procyanidins (Liu et al 1998;Lotito et al 2000), this observation is significant from nutraceutical and functional food point of view. So also, the polyphenolic compounds from grape seeds or the alcohol extracts have been reported to show a vitamin E sparing effect (Simonetti et al 2002) as well as suppression of oxidative stress (Soo-Kyong et al 2012).…”

Section: Antioxidant Capacitymentioning

confidence: 99%

Phenolic compounds, antioxidant activity and insulinotropic effect of extracts prepared from grape (Vitis vinifera L) byproducts

et al. 2013

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Grape byproducts are a rich source of phenolics having immense medicinal properties, but usually wasted from juice/wine processing industries. The present study investigates the phenolic antioxidants and the insulinotropic effect of extracts prepared from seed, skin and stems of two red wine grape cultivars: Pusa Navarang and Merlot. Pusa Navarang cultivar has shown high amounts of total phenolics (95.8 mg/ml), flavonoids (30.5 mg/ml) and flavan-3-ols (21.8 mg/ml) in seed extract and total anthocyanin (4.9 mg/ml) in its skin extract as compared to Merlot cultivar. As determined using HPLC, higher amounts of catechin hydrate (14909 mg/l) and epicatechin (9299 mg/l) were observed in its seed extract, while quercetin hydrate (5849 mg/l) was abundant in its skin extract. Similarly, ferric reducing antioxidant power (FRAP) and ABTS + . [2,2′-azinobis (3-ethylbenzothiazoline)-6-sulfonic acid] and DPPH. (1,1-diphenyl-2-picrylhy-drazyl) radicals scavenging, were higher in its seed extract, respectively being 134.8 mg/ml of Quercetin equivalent (QE), 18.7 mM of trolox equivalent (TE) and 33.5 mM of TE. Strong correlation was obtained between FRAP and total phenolics, flavonoids and flavan-3-ols contents with correlation coefficients (r 2 ) of 0.915, 0.738 and 0.838 respectively. Interestingly, there was a 2-8 fold increase in insulin secretion by isolated mice pancreatic islets at 5.5 mM and 16.5 mM glucose concentration in presence of various extracts. Overall, the seed, skin and stem byproducts of both cultivars are rich sources of phenolics and antioxidants and represent a source of new insulin secretagogues.

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Section: Antioxidant Capacitymentioning

confidence: 99%

Phenolic compounds, antioxidant activity and insulinotropic effect of extracts prepared from grape (Vitis vinifera L) byproducts

et al. 2013

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“…Pycnogeneol also inhibited the macrophage oxidative burst, lipoprotein oxidation, and hydroxyl-radical-induced DNA damage [22]. More recently, we have shown that pycnogenol enhances immune and hemopoietic functions and counters learning impairment and memory deficit in senescence-accelerated mice [23,24]. In this study, we determined the effects of pycnogenol on TNF-h-induced activation of NF-sB and expression of VCAM-1 and ICAM-1.…”

Section: Review Articlementioning

confidence: 99%

Pycnogenol inhibits tumor necrosis factor- ? -induced nuclear factor kappa B activation and adhesion molecule expression in human vascular endothelial cells

Peng¹,

Wei²,

Lau³

2000

Cellular and Molecular Life Sciences (CMLS)

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The transcriptional regulatory protein nuclear factor kappa B (NF-kappa B) participates in the control of gene expression of many modulators of inflammatory and immune responses, including vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1). The heightened expression of these adhesion molecules has been reported to play a critical role in atherosclerosis, inflammation, ischemic vascular disorders, diabetes, and cancer metastasis. In the present study, we investigated the effect of pycnogenol, an antioxidant phytochemical, on the activation of NF-kappa B and the induction of VCAM-1 and ICAM-1 in tumor necrosis factor (TNF)-alpha-treated human umbilical vein endothelial cells (HUVECs). Gel-shift analysis of HUVEC demonstrated that pretreatment with pycnogenol exhibited a concentration-dependent suppression of TNF-alpha-induced activation of NF-kappa B. Induction of VCAM-1 and ICAM-1 surface expression by TNF-alpha was dose-dependently reduced by pycnogenol. TNF-alpha significantly increased the release of superoxide anion and hydrogen peroxide from HUVECs. Pycnogenol dose-dependently inhibited their release. The ability of pycnogenol to inhibit NF-kappa B activation and VCAM-1 and ICAM-1 expression suggests that this phytochemical may play an important role in halting or preventing the atherogenic process.

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“…However, it is not known whether these effects of vitamin E are attributable to its antioxidant or some other function. In addition to vitamins, several other anti-oxidant substances are being screended for anti-aging effects, and some of these are found to have beneficial effects on the immune system (510,511).…”

Section: Vitamins and Minerals; Anti-oxidantsmentioning

confidence: 99%

T cells and aging update February 1999

Pawelec¹

1999

Front Biosci

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T cell immunosenescence 218effects of dysregulated immune responses in the elderly by supplementation or other approaches may result in an enhancement of their quality of life, and significant reductions in the cost of medical care in old age. FACTORS CONTRIBUTING TO IMMUNO-SENESCENCE HematopoiesisDysregulated hematopoiesis is seen in elderly individuals, raising the possibility that this could contribute to altered immune function in the aged. Hematopoiesis in man may be compromised because of a severely reduced capacity to produce colony stimulating factors (44) and increased production of pro-inflammatory factors such as IL 6 (45), because lower numbers of progenitor cells are present in the BM (46) and because of an age-related decline in proliferative potential of putative haematopoietic stem cells (HSC) (47). In mice, the repopulating potential of murine fetal liver-derived HSC is higher than that of adult BM-derived stem cells (48), suggesting possible aging of the HSC themselves. Normal cells with shorter telomeres possess less remaining replicative capacity than those with longer telomeres (see section 5.2). Accordingly, HSC from adult BM were found to have shorter telomeres than fetal liver-derived or umbilical cord-derived stem cells, consistent with aging of HSC (49). Telomere lengths decreased on culture despite low level expression of telomerase in these cells (50,51), although the rate of basepair loss per population doubling of cells in culture was lower during the first two weeks, when telomerase was upregulated, than in the next two, when it was downregulated (52). The telomerase expressed is therefore functionally active but may not be able to completely maintain telomere length in aging HSC cells. True embryonic stem cells (ESC), on the other hand, which may really be immortal, do retain high levels of telomerase activity (53). On the other hand, ESC from telomerase-knockout mice show gradual telomere shortening over many population doublings (PD) resulting in slowing and eventual cessation of growth (54). Certain animals which do not downregulate telomerase manifest a permanent growth phase and little or no senescence (55,56).

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Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice

Cited by 42 publications

References 19 publications

Phenolic compounds, antioxidant activity and insulinotropic effect of extracts prepared from grape (Vitis vinifera L) byproducts

Phenolic compounds, antioxidant activity and insulinotropic effect of extracts prepared from grape (Vitis vinifera L) byproducts

Pycnogenol inhibits tumor necrosis factor- ? -induced nuclear factor kappa B activation and adhesion molecule expression in human vascular endothelial cells

T cells and aging update February 1999

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